Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020;31(2):47-51.
doi: 10.3233/JRS-201017.

Coronavirus drugs: Using plasma from recovered patients as a treatment for COVID-19

Foad Alzoughool  1 , Lo'ai Alanagreh  1
Affiliations

Coronavirus drugs: Using plasma from recovered patients as a treatment for COVID-19

Foad Alzoughool et al. Int J Risk Saf Med. 2020.

Abstract

The ongoing COVID-19 pandemic has infected nearly 3,582,233 individuals with 248,558 deaths since it was first identified in human populations in December 2019 in Wuhan, China. No antiviral therapies or vaccines are available for their treatment or prevention. Passive immunization PI through broadly neutralizing antibodies that bind to the specific antigens of SARS-CoV 2 might be a potential solution to address the immediate health threat of COVID-19 pandemic while vaccines are being developed. The PI approach in treating COVID-19 is discussed herein, including a summary of its historical applications to confront epidemics.

Keywords: COVID-19; convalescent plasma; coronaviruses; passive immunization.

PubMed Disclaimer

References

    1. Chen Y, Guo D. Molecular mechanisms of coronavirus RNA capping and methylation. Virologica Sinica. 2016. doi:10.1007/s12250-016-3726-4. - DOI - PMC - PubMed
    1. Cheng Y, Wong R, Soo YOY, Wong WS, Lee CK, Ng MHL, Chan P, Wong KC, Leung CB, Cheng G. Use of convalescent plasma therapy in SARS patients in Hong Kong. European Journal of Clinical Microbiology and Infectious Diseases. 2005. doi:10.1007/s10096-004-1271-9. - DOI - PMC - PubMed
    1. Couderc T, Khandoudi N, Grandadam M, Visse C, Gangneux N, Bagot S, Prost J-F, Lecuit M. Prophylaxis and therapy for chikungunya virus infection. The Journal of Infectious Diseases. 2009. doi:10.1086/600381. - DOI - PMC - PubMed
    1. Ge XY, Li JL, Yang XL, Chmura AA, Zhu G, Epstein JH, Mazet JK et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013. doi:10.1038/nature12711. - DOI - PMC - PubMed
    1. Gordon CL, Langan K, Charles PGP, Bellomo R, Hart GK, Torresi J, Johnson PDR, Grayson ML. Pooled human immunoglobulin therapy in critically ill patients with pandemic 2009 influenza A(H1N1) pneumonitis and immunoglobulin G2 subclass (IgG2) deficiency. Clinical Infectious Diseases. 2011. doi:10.1093/cid/ciq082. - DOI - PubMed

Substances