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Book

HIV Encephalitis

Vasudev Malik Daliparty  1 , Rashmi Balasubramanya
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

HIV Encephalitis

Vasudev Malik Daliparty et al.
Free Books & Documents

Excerpt

Human immunodeficiency virus (HIV) encephalitis, also referred to as HIV-associated neurological disorder, includes a range of neurocognitive defects of varying severity following HIV infection. The clinical presentation of this condition varies from asymptomatic or minor neurocognitive impairment to severe dementia. HIV encephalopathy, also known as acquired immunodeficiency syndrome-dementia complex, lies at the most severe end of this spectrum. The diagnosis is based on clinical neuropsychiatric evaluation and radiological studies. Prompt and effective administration of antiretroviral therapy is the most effective therapy in managing HIV encephalitis.

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Conflict of interest statement

Disclosure: Vasudev Malik Daliparty declares no relevant financial relationships with ineligible companies.

Disclosure: Rashmi Balasubramanya declares no relevant financial relationships with ineligible companies.

References

    1. Grant I, Franklin DR, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Heaton RK, CHARTER Group Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology. 2014 Jun 10;82(23):2055-62. - PMC - PubMed
    1. Wendelken LA, Jahanshad N, Rosen HJ, Busovaca E, Allen I, Coppola G, Adams C, Rankin KP, Milanini B, Clifford K, Wojta K, Nir TM, Gutman BA, Thompson PM, Valcour V. ApoE ε4 Is Associated With Cognition, Brain Integrity, and Atrophy in HIV Over Age 60. J Acquir Immune Defic Syndr. 2016 Dec 01;73(4):426-432. - PMC - PubMed
    1. Levine AJ, Service S, Miller EN, Reynolds SM, Singer EJ, Shapshak P, Martin EM, Sacktor N, Becker JT, Jacobson LP, Thompson P, Freimer N. Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults. Am J Med Genet B Neuropsychiatr Genet. 2012 Sep;159B(6):669-83. - PMC - PubMed
    1. Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008 Jul 26;372(9635):293-9. - PMC - PubMed
    1. Heaton RK, Franklin DR, Deutsch R, Letendre S, Ellis RJ, Casaletto K, Marquine MJ, Woods SP, Vaida F, Atkinson JH, Marcotte TD, McCutchan JA, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Morgello S, Simpson DM, Abramson I, Gamst AC, Fennema-Notestine C, Smith DM, Grant I, CHARTER Group Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis. 2015 Feb 01;60(3):473-80. - PMC - PubMed

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