Bleomycin
- PMID: 32310355
- Bookshelf ID: NBK555895
Bleomycin
Excerpt
Bleomycin has approval for adult use in treating squamous cell cancer of head and neck regions, Hodgkin's lymphoma, testicular carcinoma. It is also used as a sclerosing agent for malignant pleural effusions. Off-label use includes treatment of germ cell tumors and pediatric Hodgkin's lymphoma. Bleomycin is in the cytotoxic chemotherapy class of medications. This activity describes the indications, action, and contraindications for bleomycin as a valuable agent in treating various malignant cancers. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the interprofessional team in the treatment of patients with various cancers.
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References
-
- Lavoie JM, Kollmannsberger CK. Current Management of Disseminated Germ Cell Tumors. Urol Clin North Am. 2019 Aug;46(3):377-388. - PubMed
-
- Bennett JM, Reich SD. Bleomycin. Ann Intern Med. 1979 Jun;90(6):945-8. - PubMed
-
- Kong J, Yi L, Xiong Y, Huang Y, Yang D, Yan X, Shen B, Duan Y, Zhu X. The discovery and development of microbial bleomycin analogues. Appl Microbiol Biotechnol. 2018 Aug;102(16):6791-6798. - PubMed
-
- Bagheri R, Noori M, Rajayi M, Attaran D, Mohammad Hashem Asna Ashari A, Mohammadzadeh Lari S, Basiri R, Rezaeetalab F, Afghani R, Salehi M. The effect of iodopovidone versus bleomycin in chemical pleurodesis. Asian Cardiovasc Thorac Ann. 2018 Jun;26(5):382-386. - PubMed
-
- Petering DH, Byrnes RW, Antholine WE. The role of redox-active metals in the mechanism of action of bleomycin. Chem Biol Interact. 1990;73(2-3):133-82. - PubMed
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