Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Fluorescein

Amy-Grace Pothen  1 , Mayur Parmar  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Fluorescein

Amy-Grace Pothen et al.
Free Books & Documents

Excerpt

Fluorescein is a diagnostic contrast agent particularly used in various ophthalmic procedures, such as checking for any corneal or vessel abnormalities. The application of fluorescein also extends to bioimaging whole anatomic structures and even further to cellular components in immunohistological staining. This article outlines the indications, mechanism of action, adverse event profile, and contraindications for fluorescein to guide the healthcare team in evaluating ophthalmic abnormalities, infection, and pathophysiology, among other conditions.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Amy-Grace Pothen declares no relevant financial relationships with ineligible companies.

Disclosure: Mayur Parmar declares no relevant financial relationships with ineligible companies.

References

    1. Jin E, Yin H, Gui Y, Chen J, Zhang J, Liang J, Li XX, Zhao M. Fluorescein Angiographic Findings of Peripheral Retinal Vasculature after Intravitreal Conbercept versus Ranibizumab for Retinopathy of Prematurity. J Ophthalmol. 2019;2019:3935945. - PMC - PubMed
    1. Fernández-Jimenez E, Diz-Arias E, Peral A. Improving ocular surface comfort in contact lens wearers. Cont Lens Anterior Eye. 2022 Jun;45(3):101544. - PubMed
    1. Paugh JR, Tse J, Nguyen T, Sasai A, Chen E, De Jesus MT, Kwan J, Nguyen AL, Farid M, Garg S, Jester JV. Efficacy of the Fluorescein Tear Breakup Time Test in Dry Eye. Cornea. 2020 Jan;39(1):92-98. - PMC - PubMed
    1. Naik K, Magdum R, Ahuja A, Kaul S, S J, Mishra A, Patil M, Dhore DN, Alapati A. Ocular Surface Diseases in Patients With Diabetes. Cureus. 2022 Mar;14(3):e23401. - PMC - PubMed
    1. Orosco RK, Tsien RY, Nguyen QT. Fluorescence imaging in surgery. IEEE Rev Biomed Eng. 2013;6:178-87. - PMC - PubMed

Publication types

LinkOut - more resources