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Book

Argatroban

Krishna C. Mahat, Yub Raj Sedhai  1 , Prathik Krishnan  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Argatroban

Krishna C. Mahat et al.
Free Books & Documents

Excerpt

Argatroban is a medication used to manage heparin-induced thrombocytopenia (HIT), which is a rare, life-threatening complication of heparin therapy. It is a direct thrombin inhibitor, a class of anticoagulant drugs. This activity outlines the indications, action, and contraindications for argatroban as a valuable agent in the prophylaxis and treating thrombosis in patients with HIT. This activity also highlights the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the healthcare team in the management of patients with heparin-induced thrombocytopenia.

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Conflict of interest statement

Disclosure: Krishna Mahat declares no relevant financial relationships with ineligible companies.

Disclosure: Yub Raj Sedhai declares no relevant financial relationships with ineligible companies.

Disclosure: Prathik Krishnan declares no relevant financial relationships with ineligible companies.

References

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    1. Hassan Y, Awaisu A, Al-Meman AA, Aziz NA. The Pharmacotherapy of Heparin-Induced Thrombocytopenia (HIT) : A Review of Contemporary Therapeutic Challenges in Clinical Practice. Malays J Med Sci. 2008 Apr;15(2):3-13. - PMC - PubMed
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    1. Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med. 2010;61:77-90. - PMC - PubMed

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