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Alpha-blockers are medications used to manage essential hypertension, benign prostatic hyperplasia, and pheochromocytoma. These drugs work by modulating the sympathetic nervous system via alpha-adrenergic receptors, which influence vascular tone and norepinephrine release. Alpha-blockers fall into 3 categories—nonselective alpha-blockers and selective alpha-1 and alpha-2 blockers.
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