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Book

Methotrexate

Maryam Hanoodi  1 , Meenal Mittal
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Affiliations
Book

Methotrexate

Maryam Hanoodi et al.

Excerpt

Methotrexate (MTX) is an anti-metabolite commonly administered during chemotherapy and as an immunosuppressant for autoimmune diseases. This activity reviews the indications, mechanism of action, and contraindications for methotrexate as a treatment for neoplastic and autoimmune conditions. Adverse events, off-label uses, pharmacokinetics, administration methods, and key monitoring considerations are discussed to optimize patient outcomes. Relevant drug interactions and clinical toxicology are also highlighted to enhance safe and effective use.

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Conflict of interest statement

Disclosure: Maryam Hanoodi declares no relevant financial relationships with ineligible companies.

Disclosure: Meenal Mittal declares no relevant financial relationships with ineligible companies.

References

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