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. 2020 May;45(5):371-374.
doi: 10.1016/j.tibs.2020.02.005. Epub 2020 Mar 4.

Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks

Corinne Abbadie  1 , Olivier Pluquet  2
Affiliations

Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks

Corinne Abbadie et al. Trends Biochem Sci. 2020 May.

Abstract

Senescence is a complex cellular state, which can be considered as a stress response phenotype. However, the mechanisms through which cells acquire and maintain this phenotype are not fully understood. In this paper, it is argued that the unfolded protein response (UPR) may represent a signalling platform that is associated with the major senescence hallmarks.

Keywords: endoplasmic reticulum; proteostasis; secretome, metabolism; senescence; unfolded protein response.

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