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. 2020 Jul-Aug;48(4):355-359.
doi: 10.1016/j.aller.2019.12.002. Epub 2020 Apr 17.

Predicting the outcome of respiratory disease in wheezing infants using tidal flow-volume loop shape

E Keklikian  1 , P Cornes  2 , C J Cela  3 , M Sanchez Solis  4 , L García Marcos  4 , J A Castro-Rodriguez  5
Affiliations

Predicting the outcome of respiratory disease in wheezing infants using tidal flow-volume loop shape

E Keklikian et al. Allergol Immunopathol (Madr). 2020 Jul-Aug.

Abstract

Introduction and objectives: Wheezing (RW) infants with a positive asthma predictive index (API+) have a lower lung function as measured by forced expiratory techniques. Tidal flow-volume loops (TFVL) are easy to perform in infants, and sedation is not necessary.

Materials and methods: A total of 216 wheezing infants were successfully measured, and 183 of them were followed for over a year. TFVL loops were classified into one of three categories depending of their geometric shape (symmetric, convex, and concave). Respiratory rate (Rr), presence of API+, and the number of exacerbations during the following year were also recorded.

Results: Children with concave loops had more exacerbations in the following year (OR = 6.8 [IC95% 3.33;13.91]). Infants API + were also significantly more related to concave loops (OR = 10.02 [IC 95% 4.53; 22.15]). Rr was higher in infants with concave loops (44+/-15.5 vs. 36.6 +/-12.6; p < 0.01).

Conclusion: Infants with a concave TFVL have a higher probability of experiencing exacerbations in the following year, and are at a higher risk of suffering asthma.

Keywords: Asthma; Child; Infant; Respiratory function test; Wheezing.

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