Association between age and clinical characteristics and outcomes of COVID-19

Yang Liu^{1

2}, Bei Mao^{1

2}, Shuo Liang^{1

2}, Jia-Wei Yang^{1

2}, Hai-Wen Lu^{1

2}, Yan-Hua Chai^{1

2}, Lan Wang³, Li Zhang¹, Qiu-Hong Li¹, Lan Zhao¹, Yan He¹, Xiao-Long Gu⁴, Xiao-Bin Ji⁵, Li Li⁶, Zhi-Jun Jie⁷, Qiang Li⁸, Xiang-Yang Li⁹, Hong-Zhou Lu¹⁰, Wen-Hong Zhang¹¹, Yuan-Lin Song¹², Jie-Ming Qu^{13

2}, Jin-Fu Xu^{1

2}; Shanghai Clinical Treatment Experts Group for COVID-19

Affiliations

¹ Dept of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
² These authors contributed equally.
³ Dept of Pulmonary Circulation Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
⁴ Dept of Respiratory Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
⁵ Dept of Respiratory Medicine, Zhoupu Hospital of Pudong New District, Shanghai, China.
⁶ Dept of Respiratory Medicine, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China.
⁷ Dept of Respiratory and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
⁸ Dept of Respiratory and Critical Care Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.
⁹ Dept of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, China.
¹⁰ Shanghai Public Health Clinical Center, Shanghai, China.
¹¹ Dept of Infectious Disease, Huashan Hospital Fudan University, Shanghai, China.
¹² Dept of Respiratory and Critical Care Medicine, Zhongshan Hospital Fudan University, Shanghai, China.
¹³ Dept of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

PMID: 32312864
PMCID: PMC7173682
DOI: 10.1183/13993003.01112-2020

Comment

Association between age and clinical characteristics and outcomes of COVID-19

Yang Liu et al. Eur Respir J. 2020.

. 2020 May 27;55(5):2001112.

doi: 10.1183/13993003.01112-2020. Print 2020 May.

Authors

Affiliations

¹ Dept of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
² These authors contributed equally.
³ Dept of Pulmonary Circulation Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
⁴ Dept of Respiratory Medicine, Shanghai Pudong New Area People's Hospital, Shanghai, China.
⁵ Dept of Respiratory Medicine, Zhoupu Hospital of Pudong New District, Shanghai, China.
⁶ Dept of Respiratory Medicine, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China.
⁷ Dept of Respiratory and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
⁸ Dept of Respiratory and Critical Care Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.
⁹ Dept of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, China.
¹⁰ Shanghai Public Health Clinical Center, Shanghai, China.
¹¹ Dept of Infectious Disease, Huashan Hospital Fudan University, Shanghai, China.
¹² Dept of Respiratory and Critical Care Medicine, Zhongshan Hospital Fudan University, Shanghai, China.
¹³ Dept of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

PMID: 32312864
PMCID: PMC7173682
DOI: 10.1183/13993003.01112-2020

Abstract

Age significantly determined the clinical features and prognosis of COVID-19. The prognosis was worse in patients older than 60 years, calling for clinicians to pay more attention to patients of this age. https://bit.ly/34DTI05

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Conflict of interest statement

Conflict of interest: Yang Liu has nothing to disclose. Conflict of interest: Bei Mao has nothing to disclose. Conflict of interest: Shuo Liang has nothing to disclose. Conflict of interest: Jia-Wei Yang has nothing to disclose. Conflict of interest: Hai-Wen Lu has nothing to disclose. Conflict of interest: Yan-Hua Chai has nothing to disclose. Conflict of interest: Lan Wang has nothing to disclose. Conflict of interest: Li Zhang has nothing to disclose. Conflict of interest: Qiu-Hong Li has nothing to disclose. Conflict of interest: Lan Zhao has nothing to disclose. Conflict of interest: Yan He has nothing to disclose. Conflict of interest: Xiao-Long Gu has nothing to disclose. Conflict of interest: Xiao-Bin Ji has nothing to disclose. Conflict of interest: Li Li has nothing to disclose. Conflict of interest: Zhi-Jun Jie has nothing to disclose. Conflict of interest: Qiang Li has nothing to disclose. Conflict of interest: Xiang-Yang Li has nothing to disclose. Conflict of interest: Hong-Zhou Lu has nothing to disclose. Conflict of interest: Wen-Hong Zhang has nothing to disclose. Conflict of interest: Yuan-Lin Song has nothing to disclose. Conflict of interest: Jie-Ming Qu has nothing to disclose. Conflict of interest: Jin-Fu Xu has nothing to disclose.

Figures

**FIGURE 1**
Comparison of clinical features and outcomes of COVID-19 between two age groups, <60 and ≥60 years. a) Age distribution for all 221 COVID-19 patients in Shanghai. Correlations were investigated between the age of patients and b) lymphocyte count (r= −0.432, p<0.001), c) albumin level (r= −0.569, p<0.001), d) C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR), and e) radiologically affected lobes. The difference in f) disease severity (classified as mild, common, severe or critical, according to the guidelines from the National Health Commission of China [8], but with no mild patients in our cohort), g) treatment, and h) disease course and rate of respiratory failure in the two age groups were also investigated. Cure rates of COVID-19 are shown for i) all 221 patients, j) males, k) females and l) those with respiratory failure. *: p<0.05; **: p<0.01; ***: p<0.001.

See this image and copyright information in PMC

Comment on

[Interpretation of "Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 5)"].
Lin L, Li TS. Lin L, et al. Zhonghua Yi Xue Za Zhi. 2020 Feb 7;100(0):E001. doi: 10.3760/cma.j.issn.0376-2491.2020.0001. Online ahead of print. Zhonghua Yi Xue Za Zhi. 2020. PMID: 32033513 Chinese.

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Association between age and clinical characteristics and outcomes of COVID-19

Affiliations

Association between age and clinical characteristics and outcomes of COVID-19

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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References

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LinkOut - more resources

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Medical