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. 1977 Mar;358(3):401-7.
doi: 10.1515/bchm2.1977.358.1.401.

Characterization of the collagen synthesized by cultured human smooth muscle cells from fetal and adult aorta

J Rauterberg, S Allam, U Brehmer, W Wirth, W H Hauss

Characterization of the collagen synthesized by cultured human smooth muscle cells from fetal and adult aorta

J Rauterberg et al. Hoppe Seylers Z Physiol Chem. 1977 Mar.

Abstract

Smooth muscle cells were grown from explants of the tunica media of fetal and adult human aorta. Collagen was isolated after incubation with [14C]glycine and was characterized by ion-exchange chromatography. All cells investigated synthesized two types of collagen: Type I (chain composition [alpha1(I)]2alpha2) and type III (chain composition [alpha1(III)]3). The collagen made by cells from adult donors contained approximately 70% type I and 30% type III collagen. This corresponds to the collagen composition in teh original tissue. No age-relate change in the type I/type III ratio was found with cells from donors between 9 and 67 years of age. On the other hand, the type III portion of the collagen made by fetal cells was markedly less (about 15-20% of total collagen).

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