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Review
. 2019 Dec 20;33(2):213-217.
doi: 10.1080/08998280.2019.1695510. eCollection 2020 Apr.

Drug deprescription-withdrawal risk, prevention, and treatment

Affiliations
Review

Drug deprescription-withdrawal risk, prevention, and treatment

Madison K Bangert et al. Proc (Bayl Univ Med Cent). .

Abstract

In most cases, a sudden interruption of most medications has no major consequences. There are well-recognized therapies that, when withheld, can either lead to the reappearance of the symptoms they were controlling or to signs or symptoms of withdrawal. In this article, we present a table including medications that when interrupted can produce withdrawal syndromes, the signs and symptoms of the withdrawal syndrome, the time to onset and resolution of the syndrome, information regarding alternative delivery options for the drug/s when the oral route is not possible, as well as prevention and therapy.

Keywords: Deprescriptions; patient safety; withdrawal.

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References

    1. Martin P, Tamblyn R, Benedetti A, et al. . Effect of pharmacist-led educational intervention on inappropriate medication prescriptions in older adults. The D-PRESCRIBE randomized clinical trial. JAMA. 2018;320(18):1889–1898. doi:10.1001/jama.2018.16131. - DOI - PMC - PubMed
    1. Hodding GC, Jann M, Ackerman IP. Drug withdrawal syndromes: a literature review. Western J Med. 1980;133:383–391. - PMC - PubMed
    1. Centers for Disease Control and Prevention . Pocket Guide: Tapering Opioids for Chronic Pain. Washington, DC: US Department of Human and Health Services; 2018.
    1. Stotts AL, Dodrill CL, Kosten TR. Opioid dependence treatment: options in pharmacotherapy. Expert Opin Pharmacother. 2009;10(11):1727–1740. doi:10.1517/14656560903037168. - DOI - PMC - PubMed
    1. Johnson RE, Strain ED, Amass L. Buprenorphine: how to use it right. Drug Alcohol Dependence. 2003;70(2):S59–S77. doi:10.1016/S0376-8716(03)00060-7. - DOI - PubMed

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