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Review
. 2020;7(3):75-78.
doi: 10.1007/s40475-020-00205-2. Epub 2020 Apr 18.

Tracing New Clinical Manifestations in Patients with COVID-19 in Chile and Its Potential Relationship with the SARS-CoV-2 Divergence

Alfonso J Rodriguez-Morales  1   2 , Andrea Gabriela Rodriguez-Morales  3 , Claudio A Méndez  4 , Sebastián Hernández-Botero  5
Affiliations
Review

Tracing New Clinical Manifestations in Patients with COVID-19 in Chile and Its Potential Relationship with the SARS-CoV-2 Divergence

Alfonso J Rodriguez-Morales et al. Curr Trop Med Rep. 2020.

Abstract

Purpose of review: In this review, we discuss the current implications of the changing genomic epidemiology of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), etiological agent of the Coronavirus Disease 2019 (COVID-19) and its potential relationship with the change of clinical manifestations in patients with confirmed infection.

Recent findings: Over the course of the current pandemic, the virus has been found more diverse in new countries. Simultaneously, also new clinical manifestations are observed, particularly more prominent gastrointestinal and neurological findings.

Summary: SARS-CoV-2/COVID-19 is changing not only its epidemiology, but also its genomic diversity and clinical manifestations, both aspects coupled, needs to be considered in the study of this ongoing pandemic.

Keywords: COVID-19; Chile; Clinical Manifestations; Genomic Epidemiology; Latin America; SARS-CoV-2.

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Figures

Fig. 1
Fig. 1
Phylogeny of SARS-CoV-2 reconstructed by the GISAD collaboration (https://nextstrain.org/ncov) from 1455 genomes including seven strains sequenced from Chile
See this image and copyright information in PMC

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