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. 1977 Mar;15(3):796-8.
doi: 10.1128/iai.15.3.796-798.1977.

Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin

A D O'Brien, M R Thompson, P Gemski, B P Doctor, S B Formal

Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin

A D O'Brien et al. Infect Immun. 1977 Mar.

Abstract

A toxin extracted from heat-inactivated, alkaline-treated Shigella flexneri 2a showed biological properties similar to those of Shigella dysenteria 1 toxin. The S, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for HeLa cells. A serological relationship between S. flexneri 2a and S. dysenteriae 1 toxin was shown with cross neutralization tests.

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