Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2020 Apr;48(4):300060520918420.
doi: 10.1177/0300060520918420.

Effect of anesthetic technique on serum vascular endothelial growth factor C and prostaglandin E2 levels in women undergoing surgery for uterine leiomyomas

Yonghai Zhang  1 , Jingfang Yu  1 , Fan Yang  1 , Liyan Zhao  2 , Ling Ma  1 , Huiwen Zhang  1 , Xuexin Chen  1 , Hanxiang Ma  1
Affiliations
Randomized Controlled Trial

Effect of anesthetic technique on serum vascular endothelial growth factor C and prostaglandin E2 levels in women undergoing surgery for uterine leiomyomas

Yonghai Zhang et al. J Int Med Res. 2020 Apr.

Abstract

Objective: Angiogenesis is essential for growth and recurrence of uterine leiomyomas, and angiogenesis is mediated by vascular endothelial growth factor C (VEGF-C) and prostaglandin E2 (PGE2). This study investigated whether spinal anesthesia (SA) with continuous postoperative epidural analgesia attenuates postoperative changes in these angiogenic factors compared with general anesthesia (GA) with patient-controlled intravenous analgesia.

Methods: Forty-four women with uterine leiomyomas undergoing abdominal myomectomy were randomized to receive either standard SA or GA. Blood samples were taken before anesthesia and at 48 hours after surgery for measuring serum VEGF-C and PGE2 levels, which were analyzed by using enzyme-linked immunosorbent assays. Visual analog scale pain scores were used to evaluate postoperative pain.

Results: Serum VEGF-C and PGE2 levels were not significantly different preoperatively between the SA and GA groups, but they were decreased in each group at 48 hours after surgery compared with preoperatively. The change in pre- and postoperative VEGF-C levels was smaller in the GA group than in the SA group.

Conclusions: Removal of uterine leiomyomas by surgery can reduce serum VEGF-C and PGE2 levels. The anesthetic technique affects serum VEGF-C levels, which are associated with angiogenesis in surgery for leiomyomas.

Keywords: Analgesia; anesthesia; leiomyoma; prostaglandin; tumor; vascular endothelial growth factor.

PubMed Disclaimer

References

    1. Mohamed S, Ayman AH. Medical treatment of uterine leiomyoma. Reprod Sci 2012; 19: 339–353. - PMC - PubMed
    1. Lee M, Cheon K, Chae B, et al. Analysis of MED12 mutation in multiple uterine leiomyomas in South Korean patients. Int J Med Sci 2018; 15: 124–128. - PMC - PubMed
    1. Hague S, Zhang L, Oehler MK, et al. Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density. Clin Cancer Res 2000; 6: 2808–2814. - PubMed
    1. Gentry CC, Okolo SO, Fong LF, et al. Quantification of vascular endothelial growth factor-A in leiomyomas and adjacent myometrium. Clin Sci (Lond) 2001; 101: 691–695. - PubMed
    1. Flake GP, Janet A, Darlene D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 2003; 111: 1037–1054. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources