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Comment
. 2020 Apr 20;53(2):138-139.
doi: 10.1016/j.devcel.2020.03.022.

Exosomes as Sentinels against Bacterial Pathogens

Elena Panizza  1 , Richard A Cerione  2 , Marc A Antonyak  1
Affiliations
Comment

Exosomes as Sentinels against Bacterial Pathogens

Elena Panizza et al. Dev Cell. .

Abstract

The ability of cells to form and release multiple classes of extracellular vesicles (EVs) is an increasingly well-recognized phenomenon. EVs are best known as mediators of intercellular communication. However, in a recent issue of Nature, Keller et al. show that they function as decoys to mitigate bacterial toxins.

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Figures

Figure 1
Figure 1
ATG16L1-Expressing Cells Release Exosomes that Neutralize S. aureus Alpha-Toxin Upon exposure to S. aureus, ATG16L1-expressing cells release large amounts of exosomes that have the metalloprotease ADAM10 on their surfaces. The alpha-toxin released by S. aureus binds to these exosomes and becomes oligomerized and inactivated, providing a mechanism of innate immunity that effectively diminishes the virulence of pathogenic bacteria (i.e., MRSA).
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Comment on

  • Decoy exosomes provide protection against bacterial toxins.
    Keller MD, Ching KL, Liang FX, Dhabaria A, Tam K, Ueberheide BM, Unutmaz D, Torres VJ, Cadwell K. Keller MD, et al. Nature. 2020 Mar;579(7798):260-264. doi: 10.1038/s41586-020-2066-6. Epub 2020 Mar 4. Nature. 2020. PMID: 32132711 Free PMC article.

References

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