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. 2020 Aug:507:94-97.
doi: 10.1016/j.cca.2020.04.018. Epub 2020 Apr 18.

Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients

Hu Yun  1 , Zhuoran Sun  2 , Jun Wu  2 , Aiguo Tang  2 , Min Hu  2 , Zhongyuan Xiang  3
Affiliations

Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients

Hu Yun et al. Clin Chim Acta. 2020 Aug.

Abstract

Background: Novel coronavirus (COVID-19) is highly infectious and requires early detection, isolation, and treatment. We tried to find some useful information by analyzing the covid-19 screening data, so as to provide help for clinical practice.

Method: We collected nucleic acid and hematology data from 2510 patients for COVID-19 infection for retrospective analysis.

Result: COVID-19 and influenza A and B infection rates were 1.3%, 3%, and 3%, respectively. COVID-19 nucleic acid was detected in stool but not in tear samples from 8 positive patients. Among the 32 patients with COVID-19, 15 (47%) and 16 (50%) patients showed decreased lymphocyte count and lymphocyte ratio, 21(66%) and 24(75%) patients showed decreased eosinophil count and eosinophil ratio, and 18 (56%) patients showed increased C-reactive protein. Ten hematological indicators significantly differed in the blood of patients with COVID-19 and those with influenza A and B (P < 0.05). Eighteen hematological indicators significantly differed between patients with COVID-19 and negative patients (P < 0.05).

Conclusion: The positive rate of influenza A and B infection was higher than that of COVID-19. When pharyngeal swab collection may cause infection, fecal samples can be examined. Evaluation of pharyngeal swab and fecal samples can improve the positive rate of nucleic acid detection. The COVID-19 can cause some hematological indices changes.

Keywords: Hematology index; Influenza A; Influenza B; Laboratory data; Novel coronavirus.

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Conflict of interest statement

Declaration of Competing Interest The authors declared that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Changes of nucleic acid positive cases with time.
Fig. 2
Fig. 2
Changes of hematology indices novel coronavirus infected patients.
See this image and copyright information in PMC

References

    1. Lu R., Zhao X., Li J., Niu P., Yang B., Wu H. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2019;395(2020):565–574. - PMC - PubMed
    1. World Health Organization, WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020 [EB/ OL], https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at... (accessed 2 February 2020).
    1. Liu Y., Yang Y., Zhang C., Zhang C., Huang F., Wang F. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci. China Life Sci. 2020;63:364–374. doi: 10.1007/s11427-020-1643-8. - DOI - PMC - PubMed
    1. Xu X.W., Wu X.X., Jiang X.G., Xu K.J., Ying L.J., Ma C.L. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020;27:368. - PMC - PubMed
    1. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;15:395. - PMC - PubMed

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