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Review
. 2020 Jun;26(6):470-475.
doi: 10.1016/j.cardfail.2020.04.009. Epub 2020 Apr 18.

Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

Gregorio Tersalvi  1 , Marco Vicenzi  2 , Davide Calabretta  3 , Luigi Biasco  4 , Giovanni Pedrazzini  5 , Dario Winterton  6
Affiliations
Review

Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

Gregorio Tersalvi et al. J Card Fail. 2020 Jun.

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 1.8 million people worldwide, overwhelmed health care systems owing to the high proportion of critical presentations, and resulted in more than 100,000 deaths. Since the first data analyses in China, elevated cardiac troponin has been noted in a substantial proportion of patients, implicating myocardial injury as a possible pathogenic mechanism contributing to severe illness and mortality. Accordingly, high troponin levels are associated with increased mortality in patients with COVID-19. This brief review explores the available evidence regarding the association between COVID-19 and myocardial injury.

Keywords: COVID-19; Coronavirus; Myocardial injury; Myocarditis; SARS; Troponin.

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Figures

Fig 1
Fig. 1
Possible mechanisms explaining troponin elevation in patients with COVID-19. (Modified from Servier Medical Art, licensed under a Creative Common Attribution 3.0 Generic License. http://smart.servier.com/). ACE2, angiotensin-converting enzyme 2; CAD, coronary artery disease; COVID-19, coronavirus disease 2019; MI, myocardial infarction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

Comment in

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