Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr 17;9(4):1002.
doi: 10.3390/cells9041002.

A Comparative Analysis of Oocyte Development in Mammals

Rozenn Dalbies-Tran  1 , Véronique Cadoret  1   2 , Alice Desmarchais  1 , Sébastien Elis  1 , Virginie Maillard  1 , Philippe Monget  1 , Danielle Monniaux  1 , Karine Reynaud  1 , Marie Saint-Dizier  1 , Svetlana Uzbekova  1
Affiliations
Review

A Comparative Analysis of Oocyte Development in Mammals

Rozenn Dalbies-Tran et al. Cells. .

Abstract

Sexual reproduction requires the fertilization of a female gamete after it has undergone optimal development. Various aspects of oocyte development and many molecular actors in this process are shared among mammals, but phylogeny and experimental data reveal species specificities. In this chapter, we will present these common and distinctive features with a focus on three points: the shaping of the oocyte transcriptome from evolutionarily conserved and rapidly evolving genes, the control of folliculogenesis and ovulation rate by oocyte-secreted Growth and Differentiation Factor 9 and Bone Morphogenetic Protein 15, and the importance of lipid metabolism.

Keywords: Bmp15; Gdf9; evolution; gene expression; lipids; mammals; oocyte; posttranscriptional control.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Evolution patterns of oocyte expressed genes in selected species. Colored and empty circles indicate the presence of a gene or pseudogene respectively; x indicate that no gene or pseudogene were reported or could be found. The species tree on the left is not to scale.
Figure 2
Figure 2
Simplified tree of selected mouse, rat, bovine and porcine oogenesins illustrating the gene duplications that took place after speciation or divergence of these species. Branch lengths correspond to evolutionary distance. Bootstrap values in red indicate the confidence of the node.
Figure 3
Figure 3
Comparison of the role of oocyte-derived BMP15 and GDF9 (a) in small growing follicles and (b) in large antral and preovulatory follicles. For GDF9 and BMP15, letter size symbolizes the expression level. Solid lines and arrows indicate the effect of GDF9 (blue) and BMP15 (green) onto somatic cells (and onto follicular development and ovulation). Dotted lines and arrows indicate feedback actions of somatic cells onto the oocyte.
Figure 4
Figure 4
Importance of carbohydrate and lipid metabolism during oocyte maturation in five mammalian species. Brightfield microscopy pictures show the darkening of the oocyte cytoplasm (from mouse to sow) reflecting the increasing content in lipid droplets, coherent with the fatty acid amount from triglycerides and phospholipids [228,229], and the dependency on fatty acid oxidation, as assessed by the impact of pharmacological inhibition of carnitine palmitoyltransferase 1 [201,203]. The number of asterisks correlates with the amount/importance of these parameters. Carbohydrate metabolism is activated from distinct substrates.
See this image and copyright information in PMC

References

    1. Bachvarova R., De Leon V., Johnson A., Kaplan G., Paynton B.V. Changes in total RNA, polyadenylated RNA, and actin mRNA during meiotic maturation of mouse oocytes. Dev. Biol. 1985;108:325–331. doi: 10.1016/0012-1606(85)90036-3. - DOI - PubMed
    1. Gilbert I., Scantland S., Sylvestre E.-L., Gravel C., Laflamme I., Sirard M.-A., Robert C. The dynamics of gene products fluctuation during bovine pre-hatching development. Mol. Reprod. Dev. 2009;76:762–772. doi: 10.1002/mrd.21030. - DOI - PubMed
    1. Kocabas A.M., Crosby J., Ross P.J., Otu H.H., Beyhan Z., Can H., Tam W.-L., Rosa G.J.M., Halgren R.G., Lim B., et al. The transcriptome of human oocytes. Proc. Natl. Acad. Sci. USA. 2006;103:14027–14032. doi: 10.1073/pnas.0603227103. - DOI - PMC - PubMed
    1. Lequarre A.S., Traverso J.M., Marchandise J., Donnay I. Poly(A) RNA Is Reduced by Half During Bovine Oocyte Maturation but Increases when Meiotic Arrest Is Maintained with CDK Inhibitors1. Biol. Reprod. 2004;71:425–431. doi: 10.1095/biolreprod.103.026724. - DOI - PubMed
    1. Olszańska B., Borgul A. Maternal RNA content in oocytes of several mammalian and avian species. J. Exp. Zool. 1993;265:317–320. doi: 10.1002/jez.1402650313. - DOI - PubMed

Publication types

LinkOut - more resources