Microbiota and colorectal cancer: colibactin makes its mark

Janelle C Arthur^{1

2

3}

Affiliations

¹ Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. janelle_arthur@med.unc.edu.
² Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. janelle_arthur@med.unc.edu.
³ Center for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. janelle_arthur@med.unc.edu.

Comment

Janelle C Arthur. Nat Rev Gastroenterol Hepatol. 2020 Jun.

. 2020 Jun;17(6):317-318.

doi: 10.1038/s41575-020-0303-y.

Janelle C Arthur^{1

2

3}

¹ Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. janelle_arthur@med.unc.edu.
² Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. janelle_arthur@med.unc.edu.
³ Center for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. janelle_arthur@med.unc.edu.

No abstract available

Comment on

Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli.
Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, Miao Y, van der Linden R, van der Elst S; Genomics England Research Consortium; Garcia KC, Top J, Willems RJL, Giannakis M, Bonnet R, Quirke P, Meyerson M, Cuppen E, van Boxtel R, Clevers H. Pleguezuelos-Manzano C, et al. Nature. 2020 Apr;580(7802):269-273. doi: 10.1038/s41586-020-2080-8. Epub 2020 Feb 27. Nature. 2020. PMID: 32106218 Free PMC article.

1. Arthur, J. C. et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338, 120–123 (2012). - DOI
1. Pleguezuelos-Manzano, C. et al. Mutational signature in colorectal cancer caused by genotoxic pks ⁺ E. coli. Nature https://doi.org/10.1038/s41586-020-2080-8 (2020). - DOI - PubMed
1. Nougayrede, J. P. et al. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313, 848–851 (2006). - DOI
1. Healy, A. R. & Herzon, S. B. Molecular basis of gut microbiome-associated colorectal cancer: a synthetic perspective. J. Am. Chem. Soc. 139, 14817–14824 (2017). - DOI
1. Wilson, M. R. et al. The human gut bacterial genotoxin colibactin alkylates DNA. Science 363, eaar7785 (2019). - DOI