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. 2020 Feb 28;9(2):915-920.
doi: 10.4103/jfmpc.jfmpc_801_19. eCollection 2020 Feb.

Evaluation and comparison of the effect of honey, milk and combination of honey-milk on experimental induced second-degree burns of Rabit

Seyed Mehdi Hosseini  1 , Reza Fekrazad  2 , Hamid Malekzadeh  1 , Parviz Farzadinia  3 , Mohammadreza Hajiani  3
Affiliations

Evaluation and comparison of the effect of honey, milk and combination of honey-milk on experimental induced second-degree burns of Rabit

Seyed Mehdi Hosseini et al. J Family Med Prim Care. .

Abstract

Introduction: Burn can happen in any area and causes dominant changes in the quality of normal tissues. The aim of present article is evaluation and comparison the effect of milk, natural honey, and combination of honey-milk on healing of burnt wound.

Method and material: A 4-week trial study was carried out on 10 Albino New Zealand rabbits. All dry burned wound was created on the back of the scapula by a 1 * 1 cm metal block. First group received honey dressing, second group milk dressing, third group honey-milk dressing, and the fourth group 5% sulfadiazine dressing. Sampling was performed at days 1, 10, and 20. Measurement of wound size was done in days 1, 7, 14, 21, 28. The obtained data and information were analyzed by two-way ANOVA and Duncan tests using SPSS.

Results: Result show that combination of milk-honey dressing had most significant effect on the improvement of wound healing in the recipient rabbits after a 4-week study. The size of burn wound in four different group was: Honey milk combination 0.428 cm2, honey 0.547 cm2, milk 0.579 cm2 and sulfadiazine 0.873 cm2.

Conclusion: All dressing can accelerate wound healing and have promotive effect on wound healing but the combination of honey-milk had the greatest effect. Honey, milk, and sulfadiazine had next grade of effectiveness.

Keywords: Honey; milk; wound dressing; wound healing.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Preparation of second degree dry burn wound on back of rabit
Figure 2
Figure 2
Spatulation of dressing on dry burn wounds
Figure 3
Figure 3
Clinical evaluation and wound size measurement in day 14,21,28
Figure 4
Figure 4
Mean dressed wound size in different (0,7,14,21,28) days in different group of dressing(milk, honey, combination of honey-milk) in recipient rabbits
Figure 5
Figure 5
The micrograph of skin section in different group of dressing in day10. a: Milk, b: Honey, c: Honey-milk combination
See this image and copyright information in PMC

References

    1. Abhyankar SV, Vartak AM. Impact of ulinastatin on outcomes in acute burns patients. J Burn Care Res. 2018;39:109–16. - PMC - PubMed
    1. Vivó C, Galeiras R, del Caz MD. Initial evaluation and management of the critical burn patient. Med Intensiva. 2016;40:49–59. - PubMed
    1. Smolle C, Cambiaso-Daniel J, Forbes AA, Wurzer P, Hundeshagen G, Branski LK, et al. Recent trends in burn epidemiology worldwide: A systematic review. Burns. 2017;43:249–57. - PMC - PubMed
    1. Vaughn L, Beckel N. Severe burn injury, burn shock, and smoke inhalation injury in small animals. Part 1: Burn classification and pathophysiology. J Vet Emerg Crit Care (San Antonio) 2012;22:179–86. - PubMed
    1. Güldoǧan CE, Kendirci M, Tikici D, Gündoǧdu E, Yastı AÇ. Clinical infection in burn patients and its consequences. Ulus Travma Acil Cerrahi Derg. 2017;23:466–471. - PubMed

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