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. 2020 Sep;69(3):682-687.
doi: 10.1007/s12020-020-02275-8. Epub 2020 Apr 21.

Treating thyroid nodules by radiofrequency: is the delivered energy correlated with the volume reduction rate? A pilot study

Pierpaolo Trimboli  1   2 , Maurilio Deandrea  3
Affiliations

Treating thyroid nodules by radiofrequency: is the delivered energy correlated with the volume reduction rate? A pilot study

Pierpaolo Trimboli et al. Endocrine. 2020 Sep.

Abstract

Objective: Radiofrequency ablation (RFA) was proven as effective in reducing thyroid nodules' volume. However, whether technical procedure aspects could influence the volume reduction rate (VRR) has not been clarified. This retrospective pilot study aimed to analyze the correlation of RFA power, duration, and energy with VRR.

Methods: During the period from June to December 2018 two primary-care centers treated benign thyroid nodules of adult outpatients according to the same RFA procedure. Technical parameters to be investigated were the following: median power (Pmedian), effective time of treatment (Teff), energy calculated as Pmedian × Teff (Ecalc), and energy delivered per mL as Kcal × 4184 × nodule's volume (Edel). Continuous variables were analyzed by the Mann-Whitney test. Data of 1-year posttreatment follow-up were collected on December 2019 and the correlation of the above parameters with VRR was analyzed by linear regression.

Results: Forty-one nodules were included and their 1-year VRR was 66.6%. RFA was performed with a Pmedian of 55 W, Teff 10.24 min, Ecalc 31,380 J, and Edel 1473 J/mL. Edel was significantly correlated with VRR (p = 0.014) while Pmedian, Teff, and Ecalc not. A strong correlation of Edel with VRR was found in nodules <10 mL (p = 0.001) while no significant correlation was observed in nodules >10 mL.

Conclusions: This study showed that the energy delivered with RFA is the only technical parameter significantly correlated with the VRR of thyroid nodules.

Keywords: Energy; Intervention; Radiofrequency ablation; Thyroid nodule.

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References

    1. J.B. Vander, E.A. Gaston, T.R. Dawber, The significance of nontoxic thyroid nodules. Final report of a 15-year study of the incidence of thyroid malignancy. Ann. Intern. Med. 69(3), 537–540 (1968) - DOI
    1. W.M. Tunbridge, D.C. Evered, R. Hall et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin. Endocrinol. 7(6), 481–493 (1977) - DOI
    1. S. Guth, U. Theune, J. Aberle, A. Galach, C.M. Bamberger, Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur. J. Clin. Investig. 39(8), 699–706 (2009) - DOI
    1. L. Hegedüs, S.J. Bonnema, F.N. Bennedbaek, Management of simple nodular goiter: current status and future perspectives. Endocr. Rev. 24(1), 102–132 (2003) - DOI
    1. S. Filetti, C. Durante, M. Torlontano, Nonsurgical approaches to the management of thyroid nodules. Nat. Clin. Pract. Endocrinol. Metab. 2(7), 384–394 (2006) - DOI

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