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Meta-Analysis
. 2020 Apr 22;4(4):CD000031.
doi: 10.1002/14651858.CD000031.pub5.

Antidepressants for smoking cessation

Seth Howes  1 , Jamie Hartmann-Boyce  1 , Jonathan Livingstone-Banks  1 , Bosun Hong  2 , Nicola Lindson  1
Affiliations
Meta-Analysis

Antidepressants for smoking cessation

Seth Howes et al. Cochrane Database Syst Rev. .

Update in

  • Antidepressants for smoking cessation.
    Hajizadeh A, Howes S, Theodoulou A, Klemperer E, Hartmann-Boyce J, Livingstone-Banks J, Lindson N. Hajizadeh A, et al. Cochrane Database Syst Rev. 2023 May 24;5(5):CD000031. doi: 10.1002/14651858.CD000031.pub6. Cochrane Database Syst Rev. 2023. PMID: 37230961 Free PMC article. Review.

Abstract

Background: Whilst the pharmacological profiles and mechanisms of antidepressants are varied, there are common reasons why they might help people to stop smoking tobacco. Firstly, nicotine withdrawal may produce depressive symptoms and antidepressants may relieve these. Additionally, some antidepressants may have a specific effect on neural pathways or receptors that underlie nicotine addiction.

Objectives: To assess the evidence for the efficacy, safety and tolerability of medications with antidepressant properties in assisting long-term tobacco smoking cessation in people who smoke cigarettes.

Search methods: We searched the Cochrane Tobacco Addiction Specialized Register, which includes reports of trials indexed in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and PsycINFO, clinicaltrials.gov, the ICTRP, and other reviews and meeting abstracts, in May 2019.

Selection criteria: We included randomized controlled trials (RCTs) that recruited smokers, and compared antidepressant medications with placebo or no treatment, an alternative pharmacotherapy, or the same medication used in a different way. We excluded trials with less than six months follow-up from efficacy analyses. We included trials with any follow-up length in safety analyses.

Data collection and analysis: We extracted data and assessed risk of bias using standard Cochrane methods. We also used GRADE to assess the certainty of the evidence. The primary outcome measure was smoking cessation after at least six months follow-up, expressed as a risk ratio (RR) and 95% confidence intervals (CIs). We used the most rigorous definition of abstinence available in each trial, and biochemically validated rates if available. Where appropriate, we performed meta-analysis using a fixed-effect model. Similarly, we presented incidence of safety and tolerance outcomes, including adverse events (AEs), serious adverse events (SAEs), psychiatric AEs, seizures, overdoses, suicide attempts, death by suicide, all-cause mortality, and trial dropout due to drug, as RRs (95% CIs).

Main results: We included 115 studies (33 new to this update) in this review; most recruited adult participants from the community or from smoking cessation clinics. We judged 28 of the studies to be at high risk of bias; however, restricting analyses only to studies at low or unclear risk did not change clinical interpretation of the results. There was high-certainty evidence that bupropion increased long-term smoking cessation rates (RR 1.64, 95% CI 1.52 to 1.77; I2 = 15%; 45 studies, 17,866 participants). There was insufficient evidence to establish whether participants taking bupropion were more likely to report SAEs compared to those taking placebo. Results were imprecise and CIs encompassed no difference (RR 1.16, 95% CI 0.90 to 1.48; I2 = 0%; 21 studies, 10,625 participants; moderate-certainty evidence, downgraded one level due to imprecision). We found high-certainty evidence that use of bupropion resulted in more trial dropouts due to adverse events of the drug than placebo (RR 1.37, 95% CI 1.21 to 1.56; I2 = 19%; 25 studies, 12,340 participants). Participants randomized to bupropion were also more likely to report psychiatric AEs compared with those randomized to placebo (RR 1.25, 95% CI 1.15 to 1.37; I2 = 15%; 6 studies, 4439 participants). We also looked at the safety and efficacy of bupropion when combined with other non-antidepressant smoking cessation therapies. There was insufficient evidence to establish whether combination bupropion and nicotine replacement therapy (NRT) resulted in superior quit rates to NRT alone (RR 1.19, 95% CI 0.94 to 1.51; I2 = 52%; 12 studies, 3487 participants), or whether combination bupropion and varenicline resulted in superior quit rates to varenicline alone (RR 1.21, 95% CI 0.95 to 1.55; I2 = 15%; 3 studies, 1057 participants). We judged the certainty of evidence to be low and moderate, respectively; in both cases due to imprecision, and also due to inconsistency in the former. Safety data were sparse for these comparisons, making it difficult to draw clear conclusions. A meta-analysis of six studies provided evidence that bupropion resulted in inferior smoking cessation rates to varenicline (RR 0.71, 95% CI 0.64 to 0.79; I2 = 0%; 6 studies, 6286 participants), whilst there was no evidence of a difference in efficacy between bupropion and NRT (RR 0.99, 95% CI 0.91 to 1.09; I2 = 18%; 10 studies, 8230 participants). We also found some evidence that nortriptyline aided smoking cessation when compared with placebo (RR 2.03, 95% CI 1.48 to 2.78; I2 = 16%; 6 studies, 975 participants), whilst there was insufficient evidence to determine whether bupropion or nortriptyline were more effective when compared with one another (RR 1.30 (favouring bupropion), 95% CI 0.93 to 1.82; I2 = 0%; 3 studies, 417 participants). There was no evidence that any of the other antidepressants tested (including St John's Wort, selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs)) had a beneficial effect on smoking cessation. Findings were sparse and inconsistent as to whether antidepressants, primarily bupropion and nortriptyline, had a particular benefit for people with current or previous depression.

Authors' conclusions: There is high-certainty evidence that bupropion can aid long-term smoking cessation. However, bupropion also increases the number of adverse events, including psychiatric AEs, and there is high-certainty evidence that people taking bupropion are more likely to discontinue treatment compared with placebo. However, there is no clear evidence to suggest whether people taking bupropion experience more or fewer SAEs than those taking placebo (moderate certainty). Nortriptyline also appears to have a beneficial effect on smoking quit rates relative to placebo. Evidence suggests that bupropion may be as successful as NRT and nortriptyline in helping people to quit smoking, but that it is less effective than varenicline. There is insufficient evidence to determine whether the other antidepressants tested, such as SSRIs, aid smoking cessation, and when looking at safety and tolerance outcomes, in most cases, paucity of data made it difficult to draw conclusions. Due to the high-certainty evidence, further studies investigating the efficacy of bupropion versus placebo are unlikely to change our interpretation of the effect, providing no clear justification for pursuing bupropion for smoking cessation over front-line smoking cessation aids already available. However, it is important that where studies of antidepressants for smoking cessation are carried out they measure and report safety and tolerability clearly.

PubMed Disclaimer

Conflict of interest statement

SH: none reported

JHB: none reported

JLB: none reported

BH: none reported

NL: none reported

Figures

1
1
Flow diagram for 2019 search update only
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
3
3
Funnel plot of comparison: 1 Bupropion versus placebo/control, outcome: 1.1 Smoking cessation.
4
4
Funnel plot of comparison: 1 Bupropion versus placebo/control, outcome: 1.5 Serious adverse events.
5
5
Funnel plot of comparison: 1 Bupropion versus placebo/control, outcome: 1.14 Dropouts due to drug.
6
6
Funnel plot of comparison: 2 Bupropion and NRT versus NRT alone, outcome: 2.1 Smoking cessation.
1.1
1.1. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 1: Smoking cessation
1.2
1.2. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 2: Smoking cessation ‐ subgroup by level of behavioural support
1.3
1.3. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 3: Smoking cessation ‐ subgroup by mental health disorders
1.4
1.4. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 4: Adverse events
1.5
1.5. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 5: Serious adverse events
1.6
1.6. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 6: Psychiatric adverse events
1.7
1.7. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 7: Seizures
1.8
1.8. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 8: Overdoses
1.9
1.9. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 9: Suicide attempts
1.10
1.10. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 10: Death by suicide
1.11
1.11. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 11: All‐cause mortality
1.12
1.12. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 12: Anxiety
1.13
1.13. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 13: Insomnia
1.14
1.14. Analysis
Comparison 1: Bupropion versus placebo/no pharmacotherapy control, Outcome 14: Dropouts due to drug
2.1
2.1. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 1: Smoking cessation
2.2
2.2. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 2: Adverse events
2.3
2.3. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 3: Serious adverse events
2.4
2.4. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 4: Seizures
2.5
2.5. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 5: Suicide attempts
2.6
2.6. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 6: Death by suicide
2.7
2.7. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 7: All‐cause mortality
2.8
2.8. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 8: Insomnia
2.9
2.9. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 9: Anxiety
2.10
2.10. Analysis
Comparison 2: Bupropion plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 10: Dropouts due to drug
3.1
3.1. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 1: Smoking cessation
3.2
3.2. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 2: Adverse events
3.3
3.3. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 3: Serious adverse events
3.4
3.4. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 4: Psychiatric adverse events
3.5
3.5. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 5: Seizures
3.6
3.6. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 6: Overdoses
3.7
3.7. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 7: Suicide attempts
3.8
3.8. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 8: Death by suicide
3.9
3.9. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 9: All‐cause mortality
3.10
3.10. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 10: Anxiety
3.11
3.11. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 11: Insomnia
3.12
3.12. Analysis
Comparison 3: Bupropion plus varenicline versus varenicline alone, Outcome 12: Dropouts due to drug
4.1
4.1. Analysis
Comparison 4: Exploratory safety analysis: effects of bupropion only across comparisons, Outcome 1: Adverse events
4.2
4.2. Analysis
Comparison 4: Exploratory safety analysis: effects of bupropion only across comparisons, Outcome 2: Psychiatric adverse events
4.3
4.3. Analysis
Comparison 4: Exploratory safety analysis: effects of bupropion only across comparisons, Outcome 3: Serious adverse events
4.4
4.4. Analysis
Comparison 4: Exploratory safety analysis: effects of bupropion only across comparisons, Outcome 4: Dropouts due to drug
5.1
5.1. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 1: Smoking cessation
5.2
5.2. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 2: Adverse events
5.3
5.3. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 3: Serious adverse events
5.4
5.4. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 4: Psychiatric adverse events
5.5
5.5. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 5: Seizures
5.6
5.6. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 6: Overdoses
5.7
5.7. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 7: Suicide attempts
5.8
5.8. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 8: Death by suicide
5.9
5.9. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 9: All‐cause mortality
5.10
5.10. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 10: Insomnia
5.11
5.11. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 11: Anxiety
5.12
5.12. Analysis
Comparison 5: Bupropion versus varenicline, Outcome 12: Dropouts due to drug
6.1
6.1. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 1: Smoking cessation
6.2
6.2. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 2: Adverse events
6.3
6.3. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 3: Serious adverse events
6.4
6.4. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 4: Psychiatric adverse events
6.5
6.5. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 5: Seizures
6.6
6.6. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 6: Overdoses
6.7
6.7. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 7: Suicide attempts
6.8
6.8. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 8: Death by suicide
6.9
6.9. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 9: All‐cause mortality
6.10
6.10. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 10: Insomnia
6.11
6.11. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 11: Anxiety
6.12
6.12. Analysis
Comparison 6: Bupropion versus nicotine replacement therapy (NRT), Outcome 12: Dropouts due to drug
7.1
7.1. Analysis
Comparison 7: Bupropion versus nortriptyline, Outcome 1: Smoking cessation
7.2
7.2. Analysis
Comparison 7: Bupropion versus nortriptyline, Outcome 2: Serious adverse events
7.3
7.3. Analysis
Comparison 7: Bupropion versus nortriptyline, Outcome 3: Insomnia
7.4
7.4. Analysis
Comparison 7: Bupropion versus nortriptyline, Outcome 4: Dropouts due to drug
8.1
8.1. Analysis
Comparison 8: Bupropion versus gabapentin, Outcome 1: Serious adverse events
8.2
8.2. Analysis
Comparison 8: Bupropion versus gabapentin, Outcome 2: Dropouts due to drug
9.1
9.1. Analysis
Comparison 9: Bupropion (different doses), Outcome 1: Smoking cessation
9.2
9.2. Analysis
Comparison 9: Bupropion (different doses), Outcome 2: Serious adverse events
9.3
9.3. Analysis
Comparison 9: Bupropion (different doses), Outcome 3: Overdoses
9.4
9.4. Analysis
Comparison 9: Bupropion (different doses), Outcome 4: Suicide attempts
9.5
9.5. Analysis
Comparison 9: Bupropion (different doses), Outcome 5: Death by suicide
9.6
9.6. Analysis
Comparison 9: Bupropion (different doses), Outcome 6: All‐cause mortality
9.7
9.7. Analysis
Comparison 9: Bupropion (different doses), Outcome 7: Insomnia
9.8
9.8. Analysis
Comparison 9: Bupropion (different doses), Outcome 8: Anxiety
9.9
9.9. Analysis
Comparison 9: Bupropion (different doses), Outcome 9: Dropouts due to drug
10.1
10.1. Analysis
Comparison 10: Nortriptyline versus placebo, Outcome 1: Smoking cessation
10.2
10.2. Analysis
Comparison 10: Nortriptyline versus placebo, Outcome 2: Serious adverse events
10.3
10.3. Analysis
Comparison 10: Nortriptyline versus placebo, Outcome 3: Insomnia
10.4
10.4. Analysis
Comparison 10: Nortriptyline versus placebo, Outcome 4: Anxiety
10.5
10.5. Analysis
Comparison 10: Nortriptyline versus placebo, Outcome 5: Dropouts due to drug
11.1
11.1. Analysis
Comparison 11: Selective serotonin reuptake inhibitors (SSRIs) versus placebo, Outcome 1: Smoking cessation
11.2
11.2. Analysis
Comparison 11: Selective serotonin reuptake inhibitors (SSRIs) versus placebo, Outcome 2: Adverse events
11.3
11.3. Analysis
Comparison 11: Selective serotonin reuptake inhibitors (SSRIs) versus placebo, Outcome 3: Dropouts due to drug
12.1
12.1. Analysis
Comparison 12: Monoamine oxidase inhibitor (MAOI) versus placebo, Outcome 1: Smoking cessation
12.2
12.2. Analysis
Comparison 12: Monoamine oxidase inhibitor (MAOI) versus placebo, Outcome 2: Adverse events
12.3
12.3. Analysis
Comparison 12: Monoamine oxidase inhibitor (MAOI) versus placebo, Outcome 3: Psychiatric adverse events
12.4
12.4. Analysis
Comparison 12: Monoamine oxidase inhibitor (MAOI) versus placebo, Outcome 4: Serious adverse events
12.5
12.5. Analysis
Comparison 12: Monoamine oxidase inhibitor (MAOI) versus placebo, Outcome 5: Insomnia
12.6
12.6. Analysis
Comparison 12: Monoamine oxidase inhibitor (MAOI) versus placebo, Outcome 6: Anxiety
12.7
12.7. Analysis
Comparison 12: Monoamine oxidase inhibitor (MAOI) versus placebo, Outcome 7: Dropouts due to drug
13.1
13.1. Analysis
Comparison 13: Venlafaxine versus placebo, Outcome 1: Smoking cessation
13.2
13.2. Analysis
Comparison 13: Venlafaxine versus placebo, Outcome 2: Dropouts due to drug
14.1
14.1. Analysis
Comparison 14: Hypericum (St John's wort) versus placebo, Outcome 1: Smoking cessation
14.2
14.2. Analysis
Comparison 14: Hypericum (St John's wort) versus placebo, Outcome 2: Serious adverse events
14.3
14.3. Analysis
Comparison 14: Hypericum (St John's wort) versus placebo, Outcome 3: All‐cause mortality
14.4
14.4. Analysis
Comparison 14: Hypericum (St John's wort) versus placebo, Outcome 4: Dropouts due to drug
15.1
15.1. Analysis
Comparison 15: S‐Adenosyl‐L‐Methionine (SAMe) versus placebo, Outcome 1: Smoking cessation
15.2
15.2. Analysis
Comparison 15: S‐Adenosyl‐L‐Methionine (SAMe) versus placebo, Outcome 2: Adverse events
15.3
15.3. Analysis
Comparison 15: S‐Adenosyl‐L‐Methionine (SAMe) versus placebo, Outcome 3: Insomnia
15.4
15.4. Analysis
Comparison 15: S‐Adenosyl‐L‐Methionine (SAMe) versus placebo, Outcome 4: Dropouts due to drug
16.1
16.1. Analysis
Comparison 16: Nortriptyline plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 1: Smoking cessation
16.2
16.2. Analysis
Comparison 16: Nortriptyline plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 2: Insomnia
16.3
16.3. Analysis
Comparison 16: Nortriptyline plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 3: Dropouts due to drug
17.1
17.1. Analysis
Comparison 17: Selective serotonin reuptake inhibitor (SSRI) plus NRT versus NRT alone, Outcome 1: Smoking cessation
18.1
18.1. Analysis
Comparison 18: Selegeline plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 1: Serious adverse events
18.2
18.2. Analysis
Comparison 18: Selegeline plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 2: Dropouts due to drug
19.1
19.1. Analysis
Comparison 19: EVT302 plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 1: Adverse events
19.2
19.2. Analysis
Comparison 19: EVT302 plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 2: Serious adverse events
19.3
19.3. Analysis
Comparison 19: EVT302 plus nicotine replacement therapy (NRT) versus NRT alone, Outcome 3: Dropouts due to drug
20.1
20.1. Analysis
Comparison 20: Fluoxetine (30 mg versus 60 mg), Outcome 1: Smoking cessation
20.2
20.2. Analysis
Comparison 20: Fluoxetine (30 mg versus 60 mg), Outcome 2: Dropouts due to drug
21.1
21.1. Analysis
Comparison 21: Lazabemide (100 mg versus 200 mg), Outcome 1: Serious adverse events
21.2
21.2. Analysis
Comparison 21: Lazabemide (100 mg versus 200 mg), Outcome 2: Insomnia
21.3
21.3. Analysis
Comparison 21: Lazabemide (100 mg versus 200 mg), Outcome 3: Anxiety
21.4
21.4. Analysis
Comparison 21: Lazabemide (100 mg versus 200 mg), Outcome 4: Dropouts due to drug
22.1
22.1. Analysis
Comparison 22: Hypericum (St John's wort) (300 mg versus 600 mg), Outcome 1: Smoking cessation
22.2
22.2. Analysis
Comparison 22: Hypericum (St John's wort) (300 mg versus 600 mg), Outcome 2: Adverse events
23.1
23.1. Analysis
Comparison 23: S‐Adenosyl‐L‐Methionine (SAMe) (800 mg versus 1600 mg), Outcome 1: Adverse events
23.2
23.2. Analysis
Comparison 23: S‐Adenosyl‐L‐Methionine (SAMe) (800 mg versus 1600 mg), Outcome 2: Dropouts due to drug
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Update of

References

References to studies included in this review

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Berlin 2002 {published data only}
    1. Berlin I, Aubin HJ, Pedarriosse AM, Rames A, Lancrenon S, Lagrue G. Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation. Addiction 2002;97:1347-54. - PubMed
Berlin 2012 {published data only}
    1. Berlin I, Hunneyball IM, Greiling D, Jones SP, Fuder H, Stahl HD. A selective reversible monoamine oxidase B inhibitor in smoking cessation: effects on its own and in association with transdermal nicotine patch. Psychopharmacology 2012;223(1):89-98. 9400123000015756 - PubMed
Biberman 2003 {published data only}
    1. Biberman R, Neumann R, Katzir I, Gerber Y. A randomized controlled trial of oral selegiline plus nicotine skin patch compared with placebo plus nicotine skin patch for smoking cessation. Addiction 2003;98:1403-7. - PubMed
Blondal 1999 {published data only}
    1. Blondal T, Gudmundsson LJ, Tomasson K, Jonsdottir D, Hilmarsdottir H, Kristjansson F, et al. The effects of fluoxetine combined with nicotine inhalers in smoking cessation - a randomized trial. Addiction 1999;94:1007-15. - PubMed
Brown 2007 {published data only}
    1. Abrantes AM, Strong DR, Lloyd-Richardson EE, Niaura R, Kahler CW, Brown RA. Regular exercise as a protective factor in relapse following smoking cessation treatment. American Journal on Addictions 2009;18(1):100-1. - PubMed
    1. Brown RA, Niaura R, Lloyd-Richardson EE, Strong DR, Kahler CW, Abrantes AM, et al. Bupropion and cognitive-behavioral treatment for depression in smoking cessation. Nicotine & Tobacco Research 2007;9:721-30. - PMC - PubMed
    1. David SP, Brown RA, Papandonatos GD, Kahler CW, Lloyd-Richardson EE, Munafo MR, et al. Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. Nicotine & Tobacco Research 2007;9:821-33. - PMC - PubMed
    1. David SP, Niaura R, Papandonatos GD, Shadel WG, Burkholder GJ, Britt DM, et al. Does the DRD2-Taq1 A polymorphism influence treatment response to bupropion hydrochloride for reduction of the nicotine withdrawal syndrome? Nicotine & Tobacco Research 2003;5:935-42. - PubMed
    1. David SP, Strong DR, Leventhal AM, Lancaster MA, McGeary JE, Munafo MR, et al. Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. Addiction 2013;108(12):2202-11. - PMC - PubMed
Brown 2014 {published data only}
    1. Brown RA, Abrantes AM, Strong DR, Niaura R, Kahler CW, Miller IW, et al. Efficacy of sequential use of fluoxetine for smoking cessation in elevated depressive symptom smokers. Nicotine & Tobacco Research 2014;16(2):197-207. - PubMed
    1. Brown RA, Strong DR, Abrantes AM, Miller IW, Kahler CW, Niaura R, et al. Efficacy of sequential use of fluoxetine for smoking cessation in elevated depressive symptom smokers. Society for Research on Nicotine & Tobacco 17th Annual Meeting; 2011 February 16-19; Toronto 2011:28S. 9400123000006076 - PubMed
    1. Brown RA, Strong DR, Miller IW, Kahler CW, Niaura R, Price LH. Efficacy of sequential vs. concurrent use of fluoxetine in smoking cessation for elevated depressive symptom smokers (SYM8D). In: Society for Research on Nicotine and Tobacco 13th Annual Meeting; 2007 February 21-24, Austin (TX). 2007.
    1. Minami H, Kahler CW, Bloom EL, Strong DR, Abrantes AM, Zywiak WH, et al. Effects of depression history and sex on the efficacy of sequential versus standard fluoxetine for smoking cessation in elevated depressive symptom smokers. Addictive Disorders & Their Treatment 2015;14(1):29-39.
Cinciripini 2005 {published data only}
    1. Cinciripini PM, Tsoh JY, Friedman K, Wetter D, Cinciripini LG, Skaar KL. A placebo controlled evaluation of venlafaxine for smoking cessation: preliminary findings [Abstract A18]. In: Society for Research on Nicotine and Tobacco Annual Meeting; 1998 Mar 27-29; New Orleans (LA). 1998.
    1. Cinciripini PM, Tsoh JY, Wetter DW, Lam C, Moor C, Cinciripini L, et al. Combined effects of venlafaxine, nicotine replacement, and brief counseling on smoking cessation. Experimental and Clinical Psychopharmacology 2005;13:282-92. - PubMed
    1. Cinciripini PM, Wetter D, Minna J, Tsoh JY, Gritz ER, Baile WF. The effects of brief counseling, transdermal nicotine replacement and antidepressant therapy on smoking cessation among smokers carrying the DRD2 A1 allele (PA3A). In: Society for Research on Nicotine and Tobacco Fifth Annual Meeting; Mar 5-7 1999; San Diego, California. 1999.
    1. Cinciripini PM, Wetter DW, Tomlinson GE, Tsoh JY, Moor CA, Cinciripini LG, et al. The effects of the DRD2 polymorphism on smoking cessation and negative affect: Evidence for a pharmacogenetic effect on mood. Nicotine & Tobacco Research 2004;6:229-39. - PubMed
Cinciripini 2013 {published data only}
    1. Cinciripini PM, Green CE, Robinson JD, Karam-Hage M, Engelmann JM, Minnix JA, et al. Benefits of varenicline vs. bupropion for smoking cessation: a Bayesian analysis of the interaction of reward sensitivity and treatment. Psychopharmacology 2017;234(11):1769-79. - PMC - PubMed
    1. Cinciripini PM, Robinson JD, Karam-Hage M, Minnix JA, Lam C, Versace F, et al. Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal. JAMA Psychiatry 2013;70(5):522-33. 9400107000000437 - PMC - PubMed
    1. Cui Y, Engelmann JM, Xian J, Minnix JA, Lam CY, Karam-Hage M, et al. Pharmacological intervention and abstinence in smokers undergoing cessation treatment: a psychophysiological study. International Journal of Psychophysiology 2018;123:25-34. - PMC - PubMed
    1. Versace F, Stevens EM, Robinson JD, Cui Y, Deweese MM, Engelmann JM, et al. Brain responses to cigarette-related and emotional images in smokers during smoking cessation: no effect of varenicline or bupropion on the late positive potential. Nicotine & Tobacco Research 2017;21(2):234-40. - PMC - PubMed
Cinciripini 2018 {published data only}
    1. Cinciripini PM, Minnix JA, Green CE, Robinson JD, Engelmann JM, Versace F, et al. An RCT with the combination of varenicline and bupropion for smoking cessation: clinical implications for front line use. Addiction 2018;113:1673-82. - PMC - PubMed
Collins 2004 {published data only}
    1. Bergen AW, Javitz HS, Su L, He Y, Conti DV, Benowitz NL, et al. The DRD4 Exon III VNTR, Bupropion, and Associations With Prospective Abstinence. Nicotine & Tobacco Research 2013;15(7):1190-1200. - PMC - PubMed
    1. Berrettini WH, Wileyto EP, Epstein L, Restine S, Hawk L, Shields P, et al. Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence. Biological Psychiatry 2007;61(1):111-8. - PubMed
    1. Collins B, Wileyto P, Patterson F, Rukstalis M, Audrain-McGovern J, Kaufmann V, et al. Gender differences in smoking cessation in a placebo-controlled trial of bupropion with behavioral counseling. Nicotine & Tobacco Research 2004;6:27-37. - PubMed
    1. Conti DV, Lee W, Li D, Liu J, Van Den BD, Thomas PD, et al. Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Human Molecular Genetics 2008;17(18):2834-48. - PMC - PubMed
    1. David SP, Strong DR, Leventhal AM, Lancaster MA, McGeary JE, Munafo MR, et al. Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. Addiction 2013;108(12):2202-11. - PMC - PubMed
Covey 2002 {published data only}
    1. Berlin I, Chen H, Covey LS. Depressive mood, suicide ideation and anxiety in smokers who do and smokers who do not manage to stop smoking after a target quit date. Addiction 2010;105(12):2209-16. 9400123000005900 - PubMed
    1. Covey LS, Glassman AH, Stetner F, Rivelli S, Stage K. A randomized trial of sertraline as a cessation aid for smokers with a history of major depression. American Journal of Psychiatry 2002;159:1731-7. - PubMed
    1. Covey LS, Glassman AH, Stetner F, Rivelli S. A trial of sertraline for smokers with past major depression. Society for Research on Nicotine and Tobacco Meeting. Arlington, VA (www.srnt.org/events/abstracts99/index.htm) 2000.
    1. NCT00063323. Maintenance treatment for abstinent smokers. clinicaltrials.gov/ct2/show/NCT00063323 (first received 1 July 2003).
Cox 2012 {published data only}
    1. Berg CJ, Cox LS, Choi WS, Mayo MS, Krebill R, Bronars CA, et al. Assessment of depression among African American light smokers. Journal of Health Psychology 2012;17(2):197-206. - PMC - PubMed
    1. Buchanan TS, Cox LS, Nollen NL, Thomas JL, Berg CJ, Mayo MS, et al. Perceived treatment assignment and smoking cessation in a clinical trial of bupropion. Cancer Epidemiology, Biomarkers & Prevention 2011;20(4):721. 9400123000011648
    1. Buchanan TS, Sanderson Cox L, Thomas JL, Nollen NL, Berg CJ, Mayo MS, et al. Perceived treatment assignment and smoking cessation in a clinical trial of bupropion versus placebo. Nicotine & Tobacco Research 2013;15(2):567-71. - PMC - PubMed
    1. Cox LS, Faseru B, Mayo MS, Krebill R, Snow TS, Bronars CA, et al. Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. Trials 2011;12:22. 9400123000005878 - PMC - PubMed
    1. Cox LS, Nollen NL, Mayo MS, Choi WS, Faseru B, Benowitz NL, et al. Bupropion for smoking cessation in African American light smokers: a randomized controlled trial. Journal of the National Cancer Institute 2012;104(4):290-8. - PMC - PubMed
CTRI/2013/07/003830 {published data only}
    1. CTRI/2013/07/003830. A study to evaluate different strategies-(medicine, enhanced counselling, standard counselling) for stopping smoking in TB patients in TB program in India. apps.who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2013/07/003830 (first received 23 July 2013).
Da Costa 2002 {published data only}
    1. da Costa C, Younes R, Lourenco M. Smoking cessation: A randomized double-blind study comparing nortriptyline to placebo [abstract]. American Journal of Respiratory and Critical Care Medicine 2001;163(5 Suppl):A354.
    1. da Costa CL, Younes RN, Lourenco MT-C. Stopping smoking: a prospective, randomized, double-blind study comparing nortriptyline to placebo. Chest 2002;122:403-8. - PubMed
Dalsgarð 2004 {published data only}
    1. Dalsgarð OJ, Hansen NC, Søes-Petersen U, Evald T, Høegholm A, Barber J, et al. A multicenter, randomized, double-blind, placebo-controlled, 6-month trial of bupropion hydrochloride sustained-release tablets as an aid to smoking cessation in hospital employees. Nicotine & Tobacco Research 2004;6:55-61. - PubMed
    1. Dalsgarð OJ, Vestbo J. A multicenter, randomised, double-blind, placebo-controlled 6 month trial to evaluate efficacy and tolerability of bupropion hydrochloride sustained release (SR) tablets as treatment for nicotine dependency in healthcare workers and as an aid to smoking cessation (ZYB30009). Poster and oral presentation. In: European Congress on Tobacco or Health; 2002 June 20-22; Warsaw, Poland. 2002.
Ebbert 2014 {published data only}
    1. Ebbert JO, Hatsukami DK, Croghan IT, Schroeder DR, Allen SS, Hays JT, et al. Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial. JAMA 2014;311(2):155-63. - PMC - PubMed
    1. Hong AS, Elrashidi MY, Schroeder DR, Ebbert JO. Depressive symptoms among patients receiving varenicline and bupropion for smoking cessation. Journal of Substance Abuse Treatment 2015;52:78-81. - PMC - PubMed
Eisenberg 2013 {published data only}
    1. Benowitz NL, Prochaska JJ. Smoking cessation after acute myocardial infarction. Journal of the American College of Cardiology 2013;61(5):533-5. 9400123000017824 - PubMed
    1. Eisenberg MJ, Grandi SM, Gervais A, Joseph L, O'Loughlin J, Paradis G, et al. Bupropion for smoking cessation in patients hospitalized with acute myocardial infarction: A randomized, placebo-controlled trial. Canadian Journal of Cardiology 2011;27(5 Suppl 1):S344. 9400123000012454 - PubMed
    1. Eisenberg MJ, Grandi SM, Gervais A, O'Loughlin J, Paradis G, Rinfret S, et al. Bupropion for smoking cessation in patients hospitalized with acute myocardial infarction: A randomized, placebo-controlled trial. Journal of the American College of Cardiology 2013;61(5):524-32. 9400123000017546 - PubMed
    1. Filion KB, Grandi SM, Joseph L, O'Loughlin J, Paradis G, Pilote L, et al. The effect of bupropion on symptoms of depression among patients attempting to quit smoking post-myocardial infarction: the zesca trial. Circulation 2012;125 Suppl 10:P090.
    1. Grandi S, Filion K, Gervais A, Joseph L, O'Loughlin J, Paradis G, et al. The effect of adherence to treatment on smoking abstinence in patients post-acute myocardial infarction. In: 61th Annual Scientific Session of the American College of Cardiology and i2 Summit: Innovation in Intervention, ACC.12; 2012 March 24-27; Chicago (IL). 2012:E1749.
Elsasser 2002 {published data only}
    1. Elsasser GN, Guck TP, Destache CJ, Daher PM, Frey DR, Jones J, et al. Sustained release bupropion in the treatment of nicotine addiction among teenage smokers (RP-32). In: Rapid Communication Poster Abstracts. Society for Research on Nicotine and Tobacco 8th Annual Meeting; 2002 February 20-23; Savannah, Georgia. 2002.
Evins 2001 {published data only}
    1. Evins AE, Cather C, Rigotti NA, Freudenreich O, Henderson DC, Olm Shipman CM, et al. Two-year follow-up of a smoking cessation trial in patients with schizophrenia: increased rates of smoking cessation and reduction. Journal of Clinical Psychiatry 2004;65:307-11. - PubMed
    1. Evins AE, Mays VK, Rigotti NA, Tisdale T, Cather C, Goff DC. A pilot trial of bupropion added to cognitive behavioral therapy for smoking cessation in schizophrenia. Nicotine & Tobacco Research 2001;3:397-403. - PubMed
Evins 2005 {published data only}
    1. Evins AE, Cather C, Culhane M, Freudenreich O, Rigotti NA, Goff DC. Smoking cessation in schizophrenia: A double blind placebo controlled trial of bupropion SR added to cognitive behavioral therapy. Biological Psychiatry 2004;55:806.
    1. Evins AE, Cather C, Deckersbach T, Freudenreich O, Culhane MA, Olm-Shipman CM, et al. A double-blind placebo-controlled trial of bupropion sustained-release for smoking cessation in schizophrenia. Journal of Clinical Psychopharmacology 2005;25:218-25. - PubMed
    1. Evins AE, Deckersbach T, Cather C, Freudenreich O, Culhane MA, Henderson DC, et al. Independent effects of tobacco abstinence and bupropion on cognitive function in schizophrenia. Journal of Clinical Psychiatry 2005;66:1184-90. - PubMed
Evins 2007 {published data only}
    1. Evins AE, Cather C, Culhane M, Birnbaum AS, Horowitz J, Hsieh E, et al. A placebo-controlled study of bupropion SR added to high dose nicotine replacement therapy for smoking cessation or reduction in schizophrenia (POS2-104). In: Society for Research on Nicotine and Tobacco 12th Annual Meeting; 2006 February 15-18; Orlando (FL). 2006.
    1. Evins AE, Cather C, Culhane MA, Birnbaum A, Horowitz J, Hsieh E, et al. A 12-week double-blind, placebo-controlled study of bupropion SR added to high-dose dual nicotine replacement therapy for smoking cessation or reduction in schizophrenia. Journal of Clinical Psychopharmacology 2007;27:380-6. - PubMed
    1. NCT00307203. Safety and effectiveness of sustained release bupropion in treating individuals with schizophrenia who smoke. clinicaltrials.gov/ct2/show/NCT00307203 (first received 27 March 2006).
Fatemi 2013 {published data only}
    1. Fatemi SH, Yousefi MK, Kneeland RE, Liesch SB, Folsom TD, Thuras PD. Antismoking and potential antipsychotic effects of varenicline in subjects with schizophrenia or schizoaffective disorder: a double-blind placebo and bupropion-controlled study. Schizophrenia Research 2013;146(1-3):376-8. - PubMed
Ferry 1992 {published and unpublished data}
    1. Ferry LH, Robbins AS, Scariati PD, Masterson A, Abbey DE, Burchette RJ. Enhancement of smoking cessation using the antidepressant bupropion hydrochloride. Circulation 1992;86(4 Suppl 1):I-671.
Ferry 1994 {published and unpublished data}
    1. Ferry LH, Burchette RJ. Efficacy of bupropion for smoking cessation in non depressed smokers [Abstract]. Journal of Addictive Diseases 1994;13(4):249.
Fossati 2007 {published data only}
    1. Ferketich AK, Fossati R, Apolone G. An evaluation of the Italian version of the Fagerstrom Test for Nicotine Dependence. Psychological Reports 2008;102:687-94. - PubMed
    1. Fossati R, Apolone G, Negri E, Compagnoni A, La Vecchia C, Mangano S, et al. A double-blind, placebo-controlled, randomized trial of bupropion for smoking cessation in primary care. Archives of Internal Medicine 2007;167:1791-7. - PubMed
Gariti 2009 {published data only}
    1. Gariti P, Lynch K, Alterman A, Kampman K, Xie H, Varillo K. Comparing smoking treatment programs for lighter smokers with and without a history of heavier smoking. Journal of Substance Abuse Treatment 2009;37(3):247-55. 9400123000005384 - PMC - PubMed
George 2002 {published data only}
    1. George TP, Vessicchio JC, Termine A, Bregartner TA, Feingold A, Rounsaville BJ, et al. A placebo controlled trial of bupropion for smoking cessation in schizophrenia. Biological Psychiatry 2002;52:53-61. [9400123000002832] - PubMed
George 2003 {published data only}
    1. George TP, Vessicchio JC, Termine A, Jatlow PI, Kosten TR, O'Malley SS. A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation. Biological Psychiatry 2003;53(2):136-43. - PubMed
    1. Lara XD, Vessicchio JC, Termine A, Kosten TR, O'Malley SS, George TP. Selegiline versus placebo for smoking cessation in nicotine dependent refractory smokers (PO2 02). In: Society for Research on Nicotine and Tobacco 7th Annual Meeting; 2001 March 23-23; Seattle (WA). 2001:53. 9400123000002571
George 2008 {published data only}
    1. George TP, Vessicchio JC, Sacco KA, Weinberger AH, Dudas MM, Allen TM, et al. A placebo-controlled trial of bupropion combined with nicotine patch for smoking cessation in schizophrenia. Biological Psychiatry 2008;63(11):1092-6. - PMC - PubMed
    1. George TP, Vessicchio JC, Weinberger AH, Sacco KA. Sustained-release bupropion combined with transdermal nicotine patch for smoking cessation in schizophrenia (SYM11C). In: Society for Research on Nicotine and Tobacco 13th Annual Meeting; 2007 February 21-24; Austin (TX). 2007.
    1. Moss TG, Sacco KA, Allen TM, Weinberger AH, Vessicchio JC, George TP. Prefrontal cognitive dysfunction is associated with tobacco dependence treatment failure in smokers with schizophrenia. Drug and Alcohol Dependence 2009;104(1-2):94-9. 9400123000005367 - PMC - PubMed
Gilbert 2019 {published data only}
    1. Gilbert DG, Rabinovich NE, Gilbert-Matuskowitz EA, Klein KP, Pergadia ML. Smoking cessation symptoms across 67 days compared with randomized controls-moderation by nicotine replacement therapy, bupropion, and negative-affect traits. Experimental and Clinical Psychopharmacology 2019;27(6):536-51. - PMC - PubMed
Gonzales 2001 {published data only}
    1. Gonzales D, Nides M, Ferry LH, Segall N, Herrero L, Modell J, et al. Retreatment with bupropion SR: results from 12-month follow-up (RP-83). In: Rapid Communication Poster Abstracts. Society for Research on Nicotine and Tobacco 8th Annual Meeting; 2002 February 20-23; Savannah (GA). 2002.
    1. Gonzales DH, Nides MA, Ferry LH, Kustra RP, Jamerson BD, Segall N, et al. Bupropion SR as an aid to smoking cessation in smokers treated previously with bupropion: A randomized placebo-controlled study. Clinical Pharmacology and Therapeutics 2001;69:438-44. - PubMed
Gonzales 2006 {published data only}
    1. Gonzales D, Rennard SI, Nides M, Oncken C, Azoulay S, Billing CB, et al. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA 2006;296:47-55. - PubMed
    1. Gonzales D, Rennard SI, Nides M. Varenicline effective for smoking cessation. Journal of Family Practice 2006;55(10):848-9. - PubMed
    1. Hays JT, Croghan IT, Baker CL, Cappelleri JC, Bushmakin AG. Changes in health-related quality of life with smoking cessation treatment. European Journal of Public Health 2012;22(2):224-9. - PubMed
    1. Hays JT, Leischow SJ, Lawrence D, Lee TC. Adherence to treatment for tobacco dependence: association with smoking abstinence and predictors of adherence. Nicotine & Tobacco Research 2010;12(6):574-81. 9400123000005608 - PubMed
    1. Jackson KC, Nahoopii R, Said Q, Dirani R, Brixner D. An employer-based cost-benefit analysis of a novel pharmacotherapy agent for smoking cessation. Journal of Occupational & Environmental Medicine 2007;49(4):453-60. - PubMed
Górecka 2003 {published data only}
    1. Górecka D, Bednarek M, Nowinski A, Puscinska E, Goljan-Geremek A, Zielinski J. Effect of treatment for nicotine dependence in patients with COPD [Wyniki leczenia uzaleznienia od nikotyny chorych na przewlekla obturacyjna chorobe pluc]. Pneumonologia i Alergologia Polska 2003;71:411-7. - PubMed
Grant 2007 {published data only}
    1. Grant KM, Kelley SS, Smith LM, Agrawal S, Meyer JR, Romberger DJ. Bupropion and nicotine patch as smoking cessation aids in alcoholics. Alcohol 2007;41(5):381-91. - PMC - PubMed
    1. NCT00044434. Bupropion as a smoking cessation aid in alcoholics. clinicaltrials.gov/ct2/show/NCT00044434 (first received 30 August 2002).
Gray 2011 {published data only}
    1. Carpenter MJ, Baker NL, Gray KM, Upadhyaya HP. Assessment of nicotine dependence among adolescent and young adult smokers: A comparison of measures. Addictive Behaviors 2010;35(11):977-82. 9400123000005998 - PMC - PubMed
    1. Gray KM, Carpenter MJ, Baker NL, Hartwell KJ, Lewis AL, Hiott DW, et al. Bupropion SR and contingency management for adolescent smoking cessation. Journal of Substance Abuse Treatment 2011;40(1):77-86. 9400123000005880 - PMC - PubMed
    1. Gray KM, Carpenter MJ, Baker NL, Klintworth EM, Leinbach AS, Upadhyaya HP, et al. Bupropion SR and contingency management in adolescent smokers: main findings. In: College on Problems of Drug Dependence 71st Annual Meeting; 2009 June 20-25; Reno/Sparks (NV). Reno/Sparks, Nevada, 2009:74.
Gray 2012 {published data only}
    1. Gray KM, Carpenter MJ, Lewis AL, Klintworth EM, Upadhyaya HP. Varenicline versus bupropion XL for smoking cessation in older adolescents: a randomized, double-blind pilot trial. Nicotine & Tobacco Research 2012;14(2):235-9. - PMC - PubMed
Haggsträm 2006 {published data only}
    1. Haggsträm FM, Chatkin JM, Sussenbach-Vaz E, Cesari DH, Fam CF, Fritscher CC. A controlled trial of nortriptyline, sustained-release bupropion and placebo for smoking cessation: preliminary results. Pulmonary Pharmacology & Therapeutics 2006;19:205-9. - PubMed
Hall 1998 {published data only}
    1. Haas AL, Munoz RF, Humfleet GL, Reus VI, Hall SM. Influences of mood, depression history, and treatment modality on outcomes in smoking cessation. Journal of Consulting & Clinical Psychology 2004;72:563-70. - PubMed
    1. Hall SM, Gorecki JA, Reus VI, Humfleet GL, Munoz RF. Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline. Nicotine & Tobacco Research 2007;9(4):467-71. - PubMed
    1. Hall SM, Reus VI, Munoz RF, Sees KL, Humfleet G, Hartz DT, et al. Nortriptyline and cognitive-behavioral therapy in the treatment of cigarette smoking. Archives of General Psychiatry 1998;55:683-90. - PubMed
    1. Mooney ME, Reus VI, Gorecki J, Hall SM, Humfleet GL, Munoz RF, et al. Therapeutic drug monitoring of nortriptyline in smoking cessation: a multistudy analysis. Clinical Pharmacology & Therapeutics 2008;83:436-42. - PMC - PubMed
Hall 2002 {published data only}
    1. Hall SM, Gorecki JA, Reus VI, Humfleet GL, Munoz RF. Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline. Nicotine & Tobacco Research 2007;9(4):467-71. - PubMed
    1. Hall SM, Humfleet G, Maude-Griffin R, Reus VI, Munoz R, Hartz DT. Nortriptyline versus bupropion and medical management versus psychological intervention in smoking treatment (PA 5A). In: Society for Research on Nicotine and Tobacco 7th Annual Meeting; 2001 March 23-23; Seattle (WA). 2001:31.
    1. Hall SM, Humfleet GL, Reus VI, Munoz RF, Hartz DT, Maude-Griffin R. Psychological intervention and antidepressant treatment in smoking cessation. Archives of General Psychiatry 2002;59:930-6. - PubMed
    1. Hall SM, Lightwood JM, Humfleet GL, Bostrom A, Reus VI, Munoz R. Cost-effectiveness of bupropion, nortriptyline, and psychological intervention in smoking cessation. Journal of Behavioral Health Services & Research 2005;32:381-92. - PubMed
    1. Mooney ME, Reus VI, Gorecki J, Hall SM, Humfleet GL, Munoz RF, et al. Therapeutic drug monitoring of nortriptyline in smoking cessation: a multistudy analysis. Clinical Pharmacology & Therapeutics 2008;83:436-42. - PMC - PubMed
Hall 2004 {published data only}
    1. Hall SM, Humfleet GL, Reus VI, Munoz RF, Cullen J. Extended nortriptyline and psychological treatment for cigarette smoking. American Journal of Psychiatry 2004;161:2100-7. - PubMed
    1. Mooney ME, Reus VI, Gorecki J, Hall SM, Humfleet GL, Munoz RF, et al. Therapeutic drug monitoring of nortriptyline in smoking cessation: a multistudy analysis. Clinical Pharmacology & Therapeutics 2008;83:436-42. - PMC - PubMed
Hertzberg 2001 {published data only}
    1. Hertzberg MA, Moore SD, Feldman ME, Beckham JC. A preliminary study of bupropion sustained-release for smoking cessation in patients with chronic posttraumatic stress disorder. Journal of Clinical Psychopharmacology 2001;21:94-8. - PubMed
Holt 2005 {published data only}
    1. Holt S, Timu-Parata C, Ryder-Lewis S, Weatherall M, Beasley R. Efficacy of bupropion in the indigenous Maori population in New Zealand. Thorax 2005;60:120-3. - PMC - PubMed
Hurt 1997 {published and unpublished data}
    1. Dale LC, Glover ED, Sachs DP, Schroeder DR, Offord KP, Croghan IT, et al. Bupropion for smoking cessation: predictors of successful outcome. Chest 2001;119:1357-64. - PubMed
    1. Glaxo Wellcome. Presentation for FDA approval of Bupropion sustained release for smoking cessation (10 December 1996). Dr J Andrew Johnston.
    1. Hayford KE, Patten CA, Rummans TA, Schroeder DR, Offord KP, Croghan IT, et al. Efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism. British Journal of Psychiatry 1999;174:173-8. - PubMed
    1. Hurt RD, Glover ED, Sachs DPL, Dale LC, Schroeder DR. Bupropion for smoking cessation: A double-blind, placebo-controlled dose response trial. Journal of Addictive Diseases 1996;15:137.
    1. Hurt RD, Sachs DPL, Glover ED, Offord KP, Johnston JA, Dale LC, et al. A comparison of sustained-release bupropion and placebo for smoking cessation. New England Journal of Medicine 1997;337:1195-202. - PubMed
Johns 2017 {published data only}
    1. Johns DA. The efficacy of combination therapy with varenicline and bupropion for smoking cessation. Annals of Oncology 2017;28 Suppl 2:6-8.
Jorenby 1999 {published data only}
    1. Durcan MJ, White J, Jorenby DE, Fiore MC, Rennard SI, Leischow SJ, et al. Impact of prior nicotine replacement therapy on smoking cessation efficacy. American Journal of Health Behavior 2002;26:213-20. - PubMed
    1. Jamerson BD, Nides M, Jorenby DE, Donahue R, Garrett P, Johnston JA, et al. Late-term smoking cessation despite initial failure: an evaluation of bupropion sustained release, nicotine patch, combination therapy, and placebo. Clinical Therapeutics 2001;23:744-52. - PubMed
    1. Jorenby DE, Leischow SJ, Nides MA, Rennard SI, Johnston JA, Hughes AR, et al. A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. New England Journal of Medicine 1999;340:685-91. - PubMed
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Jorenby 2006 {published data only}
    1. Hays JT, Croghan IT, Baker CL, Cappelleri JC, Bushmakin AG. Changes in health-related quality of life with smoking cessation treatment. European Journal of Public Health 2012;22(2):224-9. - PubMed
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Kahn 2012 {published data only}
    1. Kahn R, Gorgon L, Jones K, McSherry F, Glover ED, Anthenelli RM, et al. Selegiline transdermal system (STS) as an aid for smoking cessation. Nicotine & Tobacco Research 2012;14(3):377-82. 9400123000014198 - PMC - PubMed
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Kalman 2011 {published data only}
    1. Kalman D, Herz L, Monti P, Kahler CW, Mooney M, Rodrigues S, et al. Incremental efficacy of adding bupropion to the nicotine patch for smoking cessation in smokers with a recent history of alcohol dependence: results from a randomized, double-blind, placebo-controlled study. Drug and Alcohol Dependence 2011;118(2-3):111-8. 9400123000011678 - PMC - PubMed
    1. Madden GJ, Kalman D. Effects of bupropion on simulated demand for cigarettes and the subjective effects of smoking. Nicotine & Tobacco Research 2010;12(4):416-22. 9400123000005651 - PMC - PubMed
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Karam‐Hage 2011 {published data only}
    1. Karam-Hage M, Strobbe S, Robinson JD, Brower KJ. Bupropion-SR for smoking cessation in early recovery from alcohol dependence: a placebo-controlled, double-blind pilot study. American Journal of Drug and Alcohol Abuse 2011;37(6):487-90. 9400123000011679 - PMC - PubMed
Killen 2000 {published data only}
    1. Killen JD, Fortmann SP, Schatzberg A, Hayward C, Varady A. Onset of major depression during treatment for nicotine dependence. Addictive Behaviors 2003;28:461-70. - PubMed
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Killen 2004 {published data only}
    1. Killen JD, Robinson TN, Ammerman S, Hayward C, Rogers J, Samuels D. Major depression among adolescent smokers undergoing treatment for nicotine dependence. Addictive Behaviors 2004;29:1517-26. - PubMed
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Killen 2010 {published data only}
    1. Killen JD, Fortmann SP, Murphy GMJ, Hayward C, Fong D, Lowenthal K, et al. Failure to improve cigarette smoking abstinence with transdermal selegiline + cognitive behavior therapy. Addiction 2010;105(9):1660-8. 9400123000005871 - PMC - PubMed
    1. NCT01330030. Selegiline patch for treatment of nicotine dependence. clinicaltrials.gov/ct2/show/NCT01330030 (first received 6 April 2011).
    1. Sarginson JE, Killen JD, Lazzeroni LC, Fortmann SP, Ryan HS, Ameli N, et al. Response to transdermal selegiline smoking cessation therapy and markers in the 15q24 chromosomal region. Nicotine & Tobacco Research 2015;17(9):1126-33. - PMC - PubMed
Levine 2010 {published data only}
    1. Creswell KG, Cheng Y, Levine MD. A test of the stress-buffering model of social support in smoking cessation: is the relationship between social support and time to relapse mediated by reduced withdrawal symptoms? Nicotine & Tobacco Research 2015;17(5):566-71. - PMC - PubMed
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    1. Levine MD, Perkins KA, Kalarchian MA, Cheng Y, Houck PR, Slane JD, et al. Bupropion and cognitive behavioural therapy for weight-concerned women smokers. Archives of Internal Medicine 2010;170(6):543-50. 9400123000005577 - PMC - PubMed
    1. Okun ML, Levine MD, Houck P, Perkins KA, Marcus MD. Subjective sleep disturbance during a smoking cessation program: associations with relapse. Addictive Behaviors 2011;36(8):861-4. 9400123000011571 - PMC - PubMed
McCarthy 2008 {published data only}
    1. McCarthy DE, Piasecki TM, Jorenby DE, Lawrence DL, Shiffman S, Baker TB. A multi-level analysis of non-significant counseling effects in a randomized smoking cessation trial. Addiction 2010;105(12):2195-208. 9400123000005902 - PMC - PubMed
    1. McCarthy DE, Piasecki TM, Lawrence DL, Fiore MC, Baker TB. Efficacy of bupropion SR and individual counseling among adults attempting to quit smoking (POS1-041). In: Society for Research on Nicotine and Tobacco 10th Annual Meeting; 2004 February 18-21; Phoenix (AZ). 2004.
    1. McCarthy DE, Piasecki TM, Lawrence DL, Jorenby DE, Shiffman S, Baker TB. Psychological mediators of bupropion sustained-release treatment for smoking cessation. Addiction 2008;103(9):1521-33. - PMC - PubMed
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    1. McCarthy DE. Mechanisms of tobacco cessation treatment: Self-report mediators of counseling and bupropion sustained release treatment. Dissertation Abstracts International: Section B: The Sciences and Engineering 2007;67(9-B):5414.
Minami 2014 {published data only}
    1. Minami H, Kahler CW, Bloom EL, Prince MA, Abrantes AM, Strong DR, et al. Effects of sequential fluoxetine and gender on prequit depressive symptoms, affect, craving, and quit day abstinence in smokers with elevated depressive symptoms: a growth curve modeling approach. Experimental and Clinical Psychopharmacology 2014;22(5):392-406. - PMC - PubMed
Moreno‐Coutino 2015 {published data only}
    1. Moreno-Coutiño A, García-Anguiano F, Ruiz-Velasco S, Medina-Mora ME. Assessment of depressive symptoms in severe smokers with minimal-mild depressive symptomatology receiving pre-smoking abstinence for integrated treatment: a randomized clinical trial. Salud Mental 2015;38(6):433-9.
    1. Moreno-Coutino A, Perez-Lopez A, Gallegos LV. Predictors of retention in a multicomponent treatment for smokers. Revista de Psiquiatria Clinica 2016;43(6):134-8.
Muramoto 2007 {published data only}
    1. Best D. Bupropion assists with tobacco cessation in adolescents but relapse is high. Journal of Pediatrics 2008;152(5):738-9. 9400123000011733 - PubMed
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    1. Leischow SJ, Muramoto ML, Matthews E, Floden LL, Grana RA. Adolescent smoking cessation with bupropion: the role of adherence. Nicotine & Tobacco Research 2016;18(5):1202-5. - PMC - PubMed
    1. Muramoto ML, Leischow SJ, Sherrill D, Matthews E, Strayer LJ. Randomized, double-blind, placebo-controlled trial of 2 dosages of sustained-release bupropion for adolescent smoking cessation. Archives of Pediatrics & Adolescent Medicine 2007;161:1068-74. - PubMed
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Myles 2004 {published data only}
    1. Myles PS, Leslie K, Angliss M, Mezzavia P, Lee L. Effectiveness of bupropion as an aid to stopping smoking before elective surgery: a randomised controlled trial. Anaesthesia 2004;59:1053-8. - PubMed
NCT00132821 {published data only}
    1. NCT00132821. Impact of smoking cessation on sleep - 5. clinicaltrials.gov/ct2/show/NCT00132821 (first received 22 August 2005).
NCT00308763 {published data only}
    1. NCT00308763. Nicotine patch and bupropion to reduce smoking rates in younger, low-income, and minority individuals. clinicaltrials.gov/ct2/show/NCT00308763 (first received 30 March 2006).
NCT00495352 {published data only}
    1. NCT00495352. The pharmacogenetic study, readiness to change, and pharmacological intervention for smoking cessation in schizophrenia. clinicaltrials.gov/ct2/show/NCT00495352 (first received 3 July 2007).
NCT00578669 {published data only}
    1. NCT00578669. Sequential use of fluoxetine for smokers With elevated depressive symptoms. clinicaltrials.gov/ct2/show/NCT00578669 (first received 21 December 2007).
NCT00593099 {published data only}
    1. NCT00593099. A preliminary study of sustained-release bupropion for smoking cessation in bipolar affective disorder. www.clinicaltrials.gov/ct2/show/NCT00593099 (first received 14 January 2008).
NCT01406223 {published data only}
    1. NCT01406223. Mechanistic evaluations of pre-cessation therapies for smoking cessation. clinicaltrials.gov/ct2/show/NCT01406223 (first recieved 1 August 2011).
Niaura 2002 {published data only}
    1. Borrelli B, Niaura R, Keuthen NJ, Goldstein MG, Depue JD, Murphy C, et al. Development of major depressive disorder during smoking-cessation treatment. Journal of Clinical Psychiatry 1996;57:534-8. - PubMed
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Nides 2006 {published data only}
    1. NCT00150241. A seven-week dose-ranging study of CP-526,555 compared with placebo and zyban for smoking cessation. clinicaltrials.gov/ct2/show/NCT00150241 (first received 8 September 2005).
    1. Nides M, Oncken C, Gonzales D, Rennard S, Watsky EJ, Anziano R, et al. Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partial agonist: Results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up. Archives of Internal Medicine 2006;166:1561-8. - PubMed
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Parsons 2009 {published data only}
    1. EudraCT 2005-000662-39. A 2x2 phase II randomized controlled trial to investigate the efficacy of NRT plus St John's wort versus NRT plus placebo in smoking cessation and to examine the efficacy of chromium nicotinate versus placebo in preventing weight gain while stopping smoking. - SJW and chromium in smoking cessation. clinicaltrialsregister.eu/ctr-search/search?query=2005-000662-39 (first received 4 October 2005).
    1. ISRCTN31302738. A 2 x 2 phase II randomised controlled trial to investigate the efficacy of St John's wort versus placebo in smoking cessation and the efficacy of chromium intake in preventing weight gain. isrctn.com/ISRCTN31302738 (first received 8 February 2006).
    1. Parsons A, Ingram J, Inglis J, Aveyard P, Johnstone E, Brown K, et al. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to prevent weight gain on smoking cessation. Drug and Alcohol Dependence 2009;102(1-3):116-22. 9400123000005315 - PubMed
Perkins 2013 {published data only}
    1. Perkins KA, Lerman C, Karelitz JL, Jao NC, Chengappa KN, Sparks GM. Sensitivity and specificity of a procedure for early human screening of novel smoking cessation medications. Addiction 2013;108(11):1962-8. - PMC - PubMed
Piper 2007 {published data only}
    1. Bekiroglu K, Russell MA, Lagoa CM, Lanza ST, Piper ME. Evaluating the effect of smoking cessation treatment on a complex dynamical system. Drug and Alcohol Dependence 2017;180:215-22. - PMC - PubMed
    1. Piper ME, Federman EB, McCarthy DE, Bolt DM, Smith SS, Fiore MC, et al. Efficacy of bupropion alone and in combination with nicotine gum. Nicotine & Tobacco Research 2007;9:947-54. - PMC - PubMed
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    1. Piper ME, Federman EB, Smith SS, Fiore MC, Baker TB. Efficacy of bupropion SR alone and combined with 4-mg gum (PA2-2). In: Society for Research on Nicotine and Tobacco 10th Annual Meeting; 2004 February 18-21, Phoenix (AZ). 2004:18.
    1. Piper ME, Federmen EB, McCarthy DE, Bolt DM, Smith SS, Fiore MC, et al. Using mediational models to explore the nature of tobacco motivation and tobacco treatment effects. Journal of Abnormal Psychology 2008;117:94-105. - PubMed
Piper 2009 {published and unpublished data}
    1. Asthana A, Johnson HM, Piper ME, Fiore MC, Baker TB, Stein JH. Effects of smoking intensity and cessation on inflammatory markers in a large cohort of active smokers. American Heart Journal 2010;160(3):458-63. 9400123000005744 - PMC - PubMed
    1. Berg KM, Piper M, Fiore M, Baker T, Jorenby DE. Alcohol use after tobacco cessation: immediate consequences. Journal of General Internal Medicine 2012;27(Suppl 2):99-574.
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    1. Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, et al. Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction 2014;109(1):128-37. - PMC - PubMed
    1. Cook JW, Lanza ST, Chu W, Baker TB, Piper ME. Anhedonia: its dynamic relations with craving, negative affect, and treatment during a quit smoking attempt. Nicotine & Tobacco Research 2017;19(6):703-9. - PMC - PubMed
Planer 2011 {published data only}
    1. Planer D, Lev I, Elitzur Y, Sharon N, Ouzan E, Pugatsch T, et al. Bupropion for smoking cessation in patients with acute coronary syndrome. Archives of Internal Medicine 2011;171(12):1055-60. 9400123000010561 - PubMed
Prochazka 1998 {published data only}
    1. Prochazka AV, Weaver MJ, Keller RT, Fryer GE, Licari PA, Lofaso D. A randomized trial of nortriptyline for smoking cessation. Archives of Internal Medicine 1998;158:2035-9. - PubMed
Prochazka 2004 {published data only}
    1. NCT00018148. Combined nortriptyline and transdermal nicotine for smoking cessation. clinicaltrials.gov/ct2/show/NCT00018148 (first received 5 July 2001).
    1. Prochazka AV, Kick S, Steinbrunn C, Miyoshi T, Fryer GE. A randomized trial of nortriptyline combined with transdermal nicotine for smoking cessation. Archives of Internal Medicine 2004;164:2229-33. - PubMed
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Richmond 2013 {published data only}
    1. Richmond R, Indig D, Butler T, Wilhelm K, Archer V, Wodak A. A randomized controlled trial of a smoking cessation intervention conducted among prisoners. Addiction 2013;108(5):966-74. - PMC - PubMed
Rigotti 2006 {published data only}
    1. Rigotti N, Thorndike A, Regan S, Pasternak R, Chang Y, McKool K, et al. Safety and efficacy of bupropion for smokers hospitalized with acute cardiovascular disease [abstract]. Nicotine & Tobacco Research 2005;7:682. - PubMed
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Rose 2013 {published data only}
    1. Rose JE, Behm FM. Adapting smoking cessation treatment according to initial response to precessation nicotine patch. American Journal of Psychiatry 2013;170:860-7. 9400107000001313 - PMC - PubMed
Rose 2014 {published data only}
    1. Rose JE, Behm FM. Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. American Journal of Psychiatry 2014;171(11):1199-205. - PMC - PubMed
    1. Rose JE, Behm FM. Combination varenicline/bupropion treatment benefits male NRT-nonresponders. In: Society for Research on Nicotine and Tobacco 19th Annual Meeting; 2013 March 13-16 Boston (MA). 2013:261.
Rose 2017 {published data only}
    1. NCT01806779. Combination bupropion/varenicline for smoking cessation in male smokers. clinicaltrials.gov/ct2/show/NCT01806779 (first received 7 March 2013).
    1. Rose JE, Behm FM. Combination varenicline/bupropion treatment benefits highly dependent smokers in an adaptive smoking cessation paradigm. Nicotine & Tobacco Research 2017;19(8):999-1002. - PMC - PubMed
Rovina 2009 {published data only}
    1. Rovina N, Nikoloutsou I, Katsani G, Dima E, Fransis K, Roussos C, et al. Effectiveness of pharmacotherapy and behavioral interventions for smoking cessation in actual clinical practice. Therapeutic Advances in Respiratory Disease 2009;3(6):279-87. 9400123000005487 - PubMed
Saules 2004 {published and unpublished data}
    1. Saules KK, Schuh LM, Arfken CL, Reed K, Kilbey MM, Schuster CR. Double-blind placebo-controlled trial of fluoxetine in smoking cessation treatment including nicotine patch and cognitive-behavioral group therapy. American Journal on Addictions 2004;13:438-46. - PubMed
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Schmitz 2007 {published data only}
    1. Schmitz JM, Stotts AL, Mooney ME, Delaune KA, Moeller GF. Bupropion and cognitive-behavioral therapy for smoking cessation in women.[erratum appears in Nicotine Tob Res. 2007 Jul;9(7):785]. Nicotine & Tobacco Research 2007;9(6):699-709. - PubMed
Schnoll 2010 {published data only}
    1. Martinez E, Tatum KL, Weber DM, Kuzla N, Pendley A, Campbell K, et al. Issues related to implementing a smoking cessation clinical trial for cancer patients. Cancer Causes & Control 2009;20(1):97-104. 9400123000005109 - PMC - PubMed
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    1. Schnoll RA, Martinez E, Langer C, Miyamoto C, Leone F. Predictors of smoking cessation among cancer patients enrolled in a smoking cessation program. Acta Oncologica 2011;50(5):678-84. 9400123000006110 - PubMed
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Selby 2003 {published and unpublished data}
    1. GlaxoSmithKline Clinical Trials Register. Study No: ZYB40001. A randomized, double-blind, placebo-controlled, 12-week smoking cessation trial of Zyban (150 mg bid) in adult smokers previously treated with Zyban. ctr.glaxowellcome.co.uk-Summary-bupropion-IV_ZYB40001.pdf (accessed 23 August 2006).
    1. Selby P, Ainslie M, Stepner N, Roberts J. Sustained-release bupropion (Zybanr) is effective in the re-treatment of relapsed adult smokers. American Journal of Respiratory and Critical Care Medicine 2003;167(7):A47.
    1. Selby P, Brands B, Stepner N. Retreatment with ZYban SR: 52 week follow-up of a Canadian Multicentre trial (POS3-63). In: Society for Research on Nicotine and Tobacco 9th Annual Meeting; 2003 February 19-22; New Orleans. 2003.
    1. Selby P, Brosky G, Baker R, Lertzman M, Dakin P, Roberts J. Zyban is effective in the retreatment of relapsed adult smokers (PO4 68). In: Society for Research on Nicotine and Tobacco 7th Annual Meeting; 2001 March 23-23; Seattle (WA). 2001:114.
Sheng 2013 {published data only}
    1. Sheng LX, Tang YL, Jiang ZN, Yao CH, Gao JY, Xu GZ, et al. Sustained-release bupropion for smoking cessation in a Chinese sample: a double-blind, placebo-controlled, randomized trial. Nicotine & Tobacco Research 2013;15(2):320-5. 9400123000018059 - PubMed
Siddiqi 2013 {published data only}
    1. Dogar O, Jawad M, Shah SK, Newell JN, Kanaan M, Khan MA, et al. Effect of cessation interventions on hookah smoking: post-hoc analysis of a cluster-randomized controlled trial. Nicotine & Tobacco Research 2014;16(6):682-8. - PubMed
    1. Siddiqi K, Khan A, Ahmad M, Dogar O, Kanaan M, Newell JN, et al. Action to stop smoking in suspected tuberculosis (assist) in Pakistan: A cluster randomized, controlled trial. Annals of Internal Medicine 2013;158(9):667-75. 9400107000000417 - PubMed
    1. Siddiqi K, Khan A, Ahmad M, Shafiq-ur-Rehman. An intervention to stop smoking among patients suspected of TB--evaluation of an integrated approach. BMC Public Health 2010;10:160. 9400123000011594 - PMC - PubMed
Simon 2004 {published data only}
    1. Caplan BJ. The "bupropion for smoking cessation" trial from a family practice perspective. Archives of Internal Medicine 2005;165:470. - PubMed
    1. Simon JA, Duncan C, Carmody TP, Hudes ES. Bupropion for smoking cessation: a randomized trial. Archives of Internal Medicine 2004;164:1797-803. - PubMed
    1. Simon JA, Duncan C, Carmody TP, Hudes ES. Bupropion plus nicotine replacement no better than replacement alone. Journal of Family Practice 2004;53:953-4.
Simon 2009 {published data only}
    1. Simon JA, Duncan C, Huggins J, Solkowitz S, Carmody TP. Sustained-release bupropion for hospital-based smoking cessation: a randomized trial. Nicotine & Tobacco Research 2009;11(6):663-9. - PubMed
Singh 2010 {published data only}
    1. Singh P, Kumar R. Assessment of the effectiveness of sustained release Bupropion and intensive physician advice in smoking cessation. Lung India 2010;27(1):11-8. 9400123000006043 - PMC - PubMed
Smith 2009 {published data only}
    1. Loh WY, Piper ME, Schlam TR, Fiore MC, Smith SS, Jorenby DE, et al. Should all smokers use combination smoking cessation pharmacotherapy? Using novel analytic methods to detect differential treatment effects over 8 weeks of pharmacotherapy. Nicotine & Tobacco Research 2012;14(2):131-41. - PMC - PubMed
    1. Piper ME, Cook JW, Schlam TR, Jorenby DE, Smith SS, Bolt DM, et al. Gender, race, and education differences in abstinence rates among participants in two randomized smoking cessation trials. Nicotine & Tobacco Research 2010;12(6):647-57. 9400123000005794 - PMC - PubMed
    1. Smith SS, McCarthy DE, Japuntich SJ, Christiansen B, Piper ME, Jorenby DE, et al. Comparative effectiveness of 5 smoking cessation pharmacotherapies in primary care clinics. Archives of Internal Medicine 2009;169(22):2148-55. 9400123000005493 - PMC - PubMed
SMK20001 {unpublished data only}
    1. SMK 20001. A multi-center, double-blind, double-dummy, placebo-controlled, randomized, parallel group, dose response evaluation of a new chemical entity (NCE) and Zyban (bupropion hydrochloride) sustained release (300mg/day) versus placebo as aids to smoking cessation. gsk-studyregister.com/en/trial-details/?id=SMK20001 (accessed 2 March 2020).
Sood 2010 {published data only}
    1. NCT00405912. St. John's wort for tobacco cessation. clinicaltrials.gov/ct2/show/NCT00405912 (first received 30 November 2006).
    1. Sood A, Ebbert JO, Prasad K, Croghan IT, Bauer B, Schroeder DR. A randomized clinical trial of St. John's wort for smoking cessation. Journal of Alternative and Complementary Medicine 2010;16(7):761-7. 9400123000005770 - PMC - PubMed
Sood 2012 {published data only}
    1. Sood A, Prasad K, Croghan IT, Schroeder DR, Ehlers SL, Ebbert JO. S-Adenosyl-L-methionine (SAMe) for smoking abstinence: A randomized clinical trial. Journal of Alternative and Complementary Medicine 2012;18(9):854-9. 9400123000015738 - PMC - PubMed
Spring 2007 {published data only}
    1. Carrington A, Doran N, Spring B. Fluoxetine moderates the association between trait-anxiety and smoking status following behavioral treatment for smoking cessation (POS4-81). In: Society for Research on Nicotine and Tobacco 9th Annual Meeting; 2003 February 19-22; New Orleans (LA). 2003.
    1. NCT00113737. Fluoxetine as a quit smoking aid for depression prone. clinicaltrials.gov/ct2/show/NCT00113737 (first received 10 June 2005).
    1. Spring B, Doran N, Pagoto S, McChargue D, Cook JW, Bailey K, et al. Fluoxetine, smoking, and history of major depression: A randomized controlled trial. Journal of Consulting & Clinical Psychology 2007;75:85-94. - PubMed
    1. Spring B, Doran N, Pagoto S, McChargue DE, Cook JW, Bailey K, et al. Reduced abstinence for smokers previously treated with fluoxetine (PA1-1). In: Society for Research on Nicotine and Tobacco 10th Annual Meeting; 2004 February 18-21; Phoenix (AZ). 2004.
Stapleton 2013 {published data only}91464711
    1. Stapleton J, West R, Hajek P, Wheeler J, Vangeli E, Abdi Z, et al. Randomized trial of NRT, bupropion, and NRT plus bupropion for smoking cessation: effectiveness in clinical practice. Addiction 2013;108(12):2193-201. [DOI: 10.1111/add.12304] - DOI - PMC - PubMed
Swan 2003 {published data only}
    1. Catz S, Jack LM, Swan GE, McClure J. Adherence to bupropion SR in a smoking cessation effectiveness trial (POS2-77). In: Society for Research on Nicotine and Tobacco 12th Annual Meeting; 2006 February 15-18; Orlando (FL). 2006.
    1. Jack LM, Swan GE, Thompson E, Curry SJ, McAfee T, Dacey S, et al. Bupropion SR and smoking cessation in actual practice: methods for recruitment, screening, and exclusion for a field trial in a managed-care setting. Preventive Medicine 2003;36:585-93. - PubMed
    1. Javitz HS, Swan GE, Zbikowski SM, Curry SJ, McAfee TA, Decker DL, et al. Cost-effectiveness of different combinations of bupropion SR dose and behavioral treatment for smoking cessation: a societal perspective. American Journal of Managed Care 2004;10:217-26. - PubMed
    1. McAfee T, Zbikowski SM, Bush T, McClure J, Swan G, Jack LM, et al. The effectiveness of bupropion SR and phone counseling for light and heavy smokers (PA2-1). In: Society for Research on Nicotine and Tobacco 10th Annual Meeting; 2004 February 18-21; Phoenix (AZ). 2004.
    1. Swan GE, Jack LM, Curry S, Chorost M, Javitz H, McAfee T, et al. Bupropion SR and counseling for smoking cessation in actual practice: Predictors of outcome. Nicotine & Tobacco Research 2003;5:911-21. - PubMed
Tashkin 2001 {published data only}
    1. Patel MK, Tashkin DP, Kanner RE, Bailey WC, Buist A, Anderson PJ, et al. A multicenter evaluation of the effects of bupropion hydrochloride sustained release tablets (Bup SR) versus placebo in a population of smokers with chronic obstructive pulmonary disease (PO130). In: 11th World Conference on Tobacco or Health; 2000 Aug 6-11; Chicago (IL). Vol. 1. 2000:118.
    1. Tashkin D, Kanner R, Bailey W, Buist S, Anderson P, Nides M, et al. Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial. Lancet 2001;357:1571-5. - PubMed
Tidey 2011 {published data only}
    1. NCT00136760. Contingent incentives plus bupropion for smoking in people with schizophrenia. clinicaltrials.gov/ct2/show/NCT00136760 (first received 29 August 2005).
    1. Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM, Reid N. Effects of contingency management and bupropion on cigarette smoking in smokers with schizophrenia. Psychopharmacology 2011;217(2):279-87. - PMC - PubMed
Tonnesen 2003 {published data only}
    1. Bollinger CT, Gilljam H, Lebargy F, Spiegel PI, Edwards J, Hider A, et al. Bupropion hydrochloride (Zyban) is effective and well tolerated as an aid to smoking cessation - a multicountry study. Abstract and presentation at 11th Annual meeting of European Respiratory Society, Berlin, September 22-26 2001. European Respiratory Journal 2001;18(Suppl 33):12s.
    1. Tonnesen P, Tonstad S, Hjalmarson A, Lebargy F, Spiegel PI, Hider A, et al. A multicentre, randomized, double-blind, placebo-controlled, 1-year study of bupropion SR for smoking cessation. Journal of Internal Medicine 2003;254:184-92. - PubMed
    1. Tonstad S, Aaserud E, Hjalmarson A, Peiffer G, Molen T, Hider A, et al. Zyban is an effective and well tolerated aid to smoking cessation in a general smoking population - a multi-country study. Society for Research on Nicotine and Tobacco 3rd Europe Conference; 2001 September 19-22; Paris, France 2001:46.
Tonstad 2003 {published data only}
    1. McRobbie H, Brath H, Astbury C, Hider A, Sweet R. Bupropion hydrochloride sustained release (SR) is an effective and well tolerated aid to smoking cessation in smokers with cardiovascular disease 12 month follow-up phase data (ZYB40014). In: Abstract and Presentation at European Respiratory Society meeting; 2002 September 14-18; Stockholm, Sweden. 2002.
    1. Tonstad S, Farsang C, Klaene G, Lewis K, Manolis A, Perruchoud AP, et al. Bupropion SR for smoking cessation in smokers with cardiovascular disease: a multicentre, randomised study. European Heart Journal 2003;24:946-55. - PubMed
    1. Spiegel PI, Lewis K, Seinost G, Astbury C, Hider A, Sweet R. Bupropion hydrochloride (Zyban) is an effective and well tolerated aid to smoking cessation in smokers with cardiovascular disease - a multicountry study. Abstract and presentation at 11th Annual meeting of European Respiratory Society, Berlin, September 22-26. European Respiratory Journal 2001;18(Suppl 33):13s.
Urdapilleta‐Herrera 2013 {published data only}
    1. Urdapilleta-Herrera E, Pina-Rosales MF, Vargas-Rojas MI, Ramirez-Venegas A, Sansores-Martinez R. Bupropion together with cognitive-conductual therapy (CBT) is an alternative for a long-term abstinence of smoking. European Respiratory Journal 2013;42(57):3347.
Uyar 2007 {published data only}
    1. Uyar M, Bayram N, Filiz A, Elbek O, Topçu A, Dikensoy O, et al. Comparison of nicotine patch and bupropion in treating tobacco dependence. European Respiratory Journal 2005;26(Suppl 49):388s.
    1. Uyar M, Filiz A, Bayram N, Elbek O, Herken H, Topcu A, et al. A randomized trial of smoking cessation. Medication versus motivation. Saudi Medical Journal 2007;28(6):922-6. - PubMed
Wagena 2005 {published data only}
    1. Quaak M, Schayck Constant P, Postma Dirkje S, Wagena Edwin J, Schooten Frederik J. Genetic variants in the serotonin transporter influence the efficacy of bupropion and nortriptyline in smoking cessation. Addiction 2012;107(1):178-87. 9400123000013216 - PubMed
    1. Schayck CP, Kaper J, Wagena EJ, Wouters EF, Severens JL. The cost-effectiveness of antidepressants for smoking cessation in chronic obstructive pulmonary disease (COPD) patients. Addiction 2009;104(12):2110-7. 9400123000005573 - PubMed
    1. Wagena EJ, Knipschild PG, Huibers MJ, Wouters EF, Schayck CP. Efficacy of bupropion and nortriptyline for smoking cessation among people who are at risk for or have chronic obstructive pulmonary disease: Results from a randomized, placebo-controlled trial. Nicotine & Tobacco Research 2005;7(4):683-4. 9400123000004372
Weinberger 2010 {published and unpublished data}
    1. Weinberger AH, George TP, Mckee SA. Differences in smoking expectancies in smokers with and without a history of major depression. Addictive Behaviors 2011;36(4):434-7. 9400123000005996 - PMC - PubMed
    1. Weinberger AH, Mckee SA, George TP. Changes in smoking expectancies in abstinent, reducing, and non-abstinent participants during a pharmacological trial for smoking cessation. Nicotine & Tobacco Research 2010;12(9):937-43. 9400123000005825 - PMC - PubMed
    1. Weinberger AH, Reutenauer EL, Jatlow PI, O'Malley SS, Potenza MN, George TP. A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers. Drug and Alcohol Dependence 2010;107(2-3):188-95. 9400123000005586 - PMC - PubMed
    1. Weinberger AH, Reutenauer EL, O'Malley SS, Potenza MN, George TP. A randomized placebo-controlled clinical trial of selegiline for smoking cessation: Preliminary results (POS5-29). Society for Research on Nicotine and Tobacco 15th Annual Meeting; 2009 April 27-30; Dublin, Ireland.
    1. Weinberger AH, Reutenauer EL, Solorzano M, O'Malley SS, Potenza MN, George TP. A randomized placebo controlled clinical trial of selegiline for smoking cessation (abstract 653). CPDD 71st Annual Meeting; 2009 June 20-25; Reno (NV).
Weiner 2012 {published data only}
    1. Mann-Wrobel MC, Bennett ME, Weiner EE, Buchanan RW, Ball MP. Smoking history and motivation to quit in smokers with schizophrenia in a smoking cessation program. Schizophrenia Research 2011;126(1-3):277-83. 9400123000006008 - PubMed
    1. Weiner E, Ball MP, Buchholz AS, Gold JM, Evins AE, McMahon RP, et al. Bupropion sustained release added to group support for smoking cessation in schizophrenia: a new randomized trial and a meta-analysis. Journal of Clinical Psychiatry 2012;73(1):95-102. 9400123000011967 - PubMed
White 2005 {published data only}
    1. White WD, Crockford D, Patten S, el Guebaly N. A randomized, open-label pilot comparison of gabapentin and bupropion SR for smoking cessation. Nicotine & Tobacco Research 2005;7(5):809-13. - PubMed
Wittchen 2011 {published data only}
    1. Wittchen HU, Hoch E, Klotsche J, Muehlig S. Smoking cessation in primary care - a randomized controlled trial of bupropion, nicotine replacements, CBT and a minimal intervention. International Journal of Methods in Psychiatric Research 2011;20(1):28-39. 9400123000009843 - PMC - PubMed
Zellweger 2005 {published data only}
    1. Puska P, Brath H, Astbury C, Hider AE. Zyban is an effective and well tolerated aid to smoking cessation in a healthcare professionals population - a multi-country study. In: Society for Research on Nicotine and Tobacco 3rd European Conference; 2001 September 19-22; Paris, France. 2001:45.
    1. Zellweger JP, Blaziene A, Astbury C, Hider A, Hogue S. Bupropion hydrochloride sustained release is an effective and well tolerated aid to smoking cessation in a healthcare professionals population - a multicountry study. Abstract and presentation at 11th Annual meeting of European Respiratory Society, Berlin, September 22-26 2001. European Respiratory Journal 2001;18(Suppl 33):166s.
    1. Zellweger JP, Boelcskei PL, Carrozzi L, Sepper R, Sweet R, Hider AZ. Bupropion SR vs placebo for smoking cessation in health care professionals. American Journal of Health Behavior 2005;29:240-9. - PubMed
Zincir 2013 {published data only}
    1. Zincir SB, Kaymak E, Sunbul EA, Zincir N. Comparison of the effects of varenicline, bupropion and nicotine replacement therapy on smoking cessation program [Vareniklin, bupropion ve nikotin yerine koyma tedavilerinin sigara birakma programini surdurme uzerine etkilerinin karsilastirilmasi]. Bulletin of Clinical Psychopharmacology 2012;22 Suppl 1:S35.
    1. Zincir SB, Zincir S, Kaymak E, Sunbul EA. Comparison of the effectiveness of varenicline, extended-release bupropion and nicotine replacement therapy on the success and the maintenance of a smoking cessation program. Klinik Psikofarmakoloji Bulteni 2013;23(3):224-30.

References to studies excluded from this review

Akbarpour 2010 {published data only}
    1. Akbarpour F, Rezaei O, Khodaie-Ardakani MR, Sheikhvatan M, Goodarzi H, Dolatshahi B. A double-blind placebo-controlled trial of bupropion for smoking abstinence and cognition improvement in schizophrenia. Minerva Psichiatrica 2010;51(4):263-9. 9400123000016548
Aryanpur 2016 {published data only}
    1. Aryanpur M, Hosseini M, Masjedi MR, Mortaz E, Tabarsi P, Soori H, et al. A randomized controlled trial of smoking cessation methods in patients newly-diagnosed with pulmonary tuberculosis. BMC Infectious Diseases 2016;16:369. - PMC - PubMed
Banham 2010 {published data only}
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Becker 2003 {unpublished data only}
    1. Becker B, Bock B, Carmona-Barros R. St. John's Wort oral spray reduces withdrawal symptoms during quitting smoking (POS4-82). In: Society for Research on Nicotine and Tobacco 9th Annual Meeting; 2003 February 19-22; New Orleans (LA). 2003.
Berlin 2005 {published data only}
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Bloch 2010 {published data only}
    1. Bloch B, Reshef A, Cohen T, Tafla A, Gathas S, Israel S, et al. Preliminary effects of bupropion and the promoter region (HTTLPR) serotonin transporter (SLC6A4) polymorphism on smoking behavior in schizophrenia. Psychiatry Research 2010;175(1-2):38-42. 9400123000005445 - PubMed
Bowen 1991 {published data only}
    1. Bowen DJ, Spring B, Fox E. Tryptophan and high-carbohydrate diets as adjuncts to smoking cessation therapy. Journal of Behavioral Medicine 1991;14(2):97-110. - PubMed
Brauer 2000 {unpublished data only}
    1. Brauer LH, Paxton DA, Stock CT, Rose JE. Selegiline and transdermal nicotine for smoking cessation. Society for Research on Nicotine and Tobacco Annual Conference; 2000 Feb 18-20; Arlington (VA) 2000.
Breitling 2008 {published data only}
    1. Breitling LP, Twardella D, Brenner H. High effectiveness of short treatment with bupropion for smoking cessation in general care. Thorax 2008;63:476-7. - PubMed
Brody 2013 {published data only}
    1. Brody AL, Mukhin AG, Stephanie Shulenberger, Mamoun MS, Kozman M, Phuong J, et al. Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. Neuropsychopharmacology 2013;38(8):1548-56. - PMC - PubMed
Carrão 2007 {published data only}
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Chan 2005 {published data only}
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Chandrashekar 2015 {published data only}
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Christenhusz 2012 {published data only}
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Cornelius 1997 {published data only}
    1. Cornelius JR, Salloum IM, Ehler JG, Jarrett PJ, Cornelius MD, Black A, et al. Double-blind fluoxetine in depressed alcoholic smokers. Psychopharmacology Bulletin 1997;33:165-70. - PubMed
Cornelius 1999 {published data only}
    1. Cornelius JR, Perkins KA, Salloum IM, Thase ME, Moss HB. Fluoxetine versus placebo to decrease the smoking of depressed alcoholic patients [letter]. Journal of Clinical Psychopharmacology 1999;19:183-4. - PubMed
Covey 2007 {published data only}
    1. Covey LS, Botello-Harbaum M, Glassman AH, Masmela J, LoDuca C, Salzman V, et al. Smokers' response to combination bupropion, nicotine patch, and counseling treatment by race/ethnicity. Ethnicity & Disease 2008;18:59-64. - PubMed
    1. Covey LS, Glassman AH, Jiang H, Fried J, Masmela J, LoDuca C, et al. A randomized trial of bupropion and/or nicotine gum as maintenance treatment for preventing smoking relapse. Addiction 2007;102:1292-302. - PubMed
Croghan 2007 {published data only}
    1. Clark MM, Hurt RD, Croghan IT, Patten CA, Novotny P, Sloan JA, et al. The prevalence of weight concerns in a smoking abstinence clinical trial. Addictive Behaviors 2006;31:1144-52. - PubMed
    1. Croghan IT, Hurt RD, Croghan GA, Sloan JA. Comparing nicotine inhaler, bupropion and nicotine inhaler plus bupropion in treating tobacco dependence [abstract]. Nicotine & Tobacco Research 2005;7:680-1.
    1. Croghan IT, Hurt RD, Dakhil SR, Croghan GA, Sloan JA, Novotny PJ, et al. Randomized comparison of a nicotine inhaler and bupropion for smoking cessation and relapse prevention. Mayo Clinic Proceedings 2007;82:186-95. - PubMed
    1. Croghan IT, Hurt RD, Ebbert JO, Croghan GA, Polk Jr OD, Stella PJ, et al. Racial differences in smoking abstinence rates in a multicenter, randomized, open-label trial in the United States. Journal of Public Health 2010;18(1):59-68. 9400123000006023 - PMC - PubMed
Cropsey 2015 {published data only}
    1. Cropsey KL, Jardin BF, Burkholder GA, Clark CB, Raper JL, Saag MS. An algorithm approach to determining smoking cessation treatment for persons living with HIV/AIDS: results of a pilot trial. Journal of Acquired Immune Deficiency Syndromes 2015;69(3):291-8. - PMC - PubMed
Dalack 1995 {published data only}
    1. Dalack GW, Glassman AH, Rivelli S, Covey LS, Stetner F. Mood, major depression, and fluoxetine response in cigarette smokers. American Journal of Psychiatry 1995;152:398-403. - PubMed
Dale 2002 {published data only}
    1. Dale LC, Ebbert JO, Schroeder DR, Croghan IT, Rasmussen DF, Trautman JA, et al. Bupropion for the treatment of nicotine dependence in spit tobacco users: a pilot study. Nicotine Tobacco Research 2002;4(3):267-74. - PubMed
Dale 2007 {published data only}
    1. Dale LC, Ebbert JO, Glover ED, Croghan IT, Schroeder DR, Severson HH, et al. Bupropion SR for the treatment of smokeless tobacco use. Drug & Alcohol Dependence 2007;90(1):56-63. - PMC - PubMed
    1. Thomas JL, Ebbert JO, Patten CA, Dale LC, Bronars CA, Schroeder DR. Measuring nicotine dependence among smokeless tobacco users. Addictive Behaviors 2006;31(9):1511-21. - PubMed
Daniela 2008 {published data only}
    1. Daniela I, Carmen C. The combination of sertraline with buspirone for smoking cessation process - The effectiveness and adverse events. Toxicology Letters 2008;180(Suppl 1):S130.
Edwards 1989 {published data only}
    1. Edwards NB, Murphy JK, Downs AD, Ackerman BJ, Rosenthal TL. Doxepin as an adjunct to smoking cessation: a double-blind pilot study. American Journal of Psychiatry 1989;146(3):373-6. - PubMed
    1. Murphy JK, Edwards NB, Downs AD, Ackerman BJ, Rosenthal TL. Effects of doxepin on withdrawal symptoms in smoking cessation. American Journal of Psychiatry 1990;147(10):1353-7. - PubMed
EUCTR2005‐006189‐32‐AT {published data only}
    1. EU Clinical Trials Register. Clinical evaluation study: "Bupropion versus Psychodynamic mental training according to Dr. Grohs for smoke withdrawal" [Klinische Evaluierungsstudie: "Bupropion versus Psychodynamisches Mentaltraining nach Dr. Grohs zur Raucherentwohnung]. who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2005-006189-32-AT (first received 1 February 2006).
Evins 2008 {published data only}
    1. Evins AE, Alpert JE, Pava J, Petersen TJ, Farabaugh AH, Fava M. A double blind placebo controlled trial of bupropion added to nicotine patch and cognitive behavioral therapy in smokers with current or past unipolar depressive disorder. Neuropsychopharmacology 2005;30 Suppl 1:S91.
    1. Evins AE, Culhane MA, Alpert JE, Pava J, Liese BS, Farabaugh A, et al. A controlled trial of bupropion added to nicotine patch and behavioral therapy for smoking cessation in adults with unipolar depressive disorders. Journal of Clinical Psychopharmacology 2008;28:660-6. - PMC - PubMed
Fatemi 2005 {published data only}
    1. Fatemi SH, Stary JM, Hatsukami DK, Murphy SE. A double-blind placebo-controlled cross over trial of bupropion in smoking reduction in schizophrenia. Schizophrenia Research 2005;76(2-3):353-6. - PubMed
Frederick 1997 {published data only}
    1. Frederick SL, Hall SM, Sees KL. The effect of venlafaxine on smoking cessation in subjects with and without a history of depression. NIDA Research Monograph 1997;174:208.
Gawin 1989 {published data only}
    1. Gawin F, Compton M, Byck R. Buspirone reduces smoking [letter]. Archives of General Psychiatry 1989;46(3):288-9. - PubMed
Gifford 2011 {published data only}
    1. Gifford EV, Kohlenberg BS, Hayes SC, Pierson HM, Piasecki MP, Antonuccio DO, et al. Does acceptance and relationship focused behavior therapy contribute to bupropion outcomes? A randomized controlled trial of functional analytic psychotherapy and acceptance and commitment therapy for smoking cessation. Behavior Therapy 2011;42(4):700-15. 9400123000012398 - PubMed
Glover 2002 {published data only}
    1. Glover ED, Glover PN, Sullivan CR, Cerullo CL, Hobbs G. A comparison of sustained-release bupropion and placebo for smokeless tobacco cessation. American Journal of Health Behavior 2002;26(5):386-93. - PubMed
Gold 2002 {published data only}
    1. Gold PB, Rubey RN, Harvey RT. Naturalistic, self-assignment comparative trial of bupropion SR, a nicotine patch, or both for smoking cessation treatment in primary care. American Journal of Addiction 2002;11(4):315-31. - PubMed
Grandi 2011 {published data only}
    1. Grandi S, Shimony A, Eisenberg MJ. The efficacy and safety of bupropion started in-hospital for smoking cessation in patients with cardiovascular disease: A systematic review and meta-analysis. Circulation 2011;124(21 Suppl 1). 9400123000012459 [9400123000012459]
Grassi 2009 {published data only}
    1. Grassi MC, Enea D, Ferketich AK, Lu B, Nencini P. A smoking ban in public places increases the efficacy of bupropion and counseling on cessation outcomes at 1 year. Nicotine & Tobacco Research 2009;11(9):1114-21. 9400123000005435 - PubMed
Hall 2009 {published data only}
    1. Hall SM, Humfleet GL, Muñoz RF, Reus VI, Robbins JA, Prochaska JJ. Extended treatment of older cigarette smokers. Addiction 2009;104(6):1043-52. 9400123000005370 - PMC - PubMed
Hall 2011 {published data only}
    1. Hall SM, Humfleet GL, Munoz RF, Reus VI, Prochaska JJ, Robbins JA. Using extended cognitive behavioral treatment and medication to treat dependent smokers. American Journal of Public Health 2011;101(12):2349-56. 9400123000011870 - PMC - PubMed
    1. Prochaska JJ, Hall SM, Humfleet G, Munoz RF, Reus V, Gorecki J, et al. Physical activity as a strategy for maintaining tobacco abstinence: a randomized trial. Preventive Medicine 2008;47(2):215-20. 9400123000004887 - PMC - PubMed
Hatsukami 2004 {published data only}
    1. Hatsukami DK, Rennard S, Patel MK, Kotlyar M, Malcolm R, Nides MA, et al. Effects of sustained-release bupropion among persons interested in reducing but not quitting smoking. American Journal of Medicine 2004;116:151-7. - PubMed
    1. Rennard S, Hatsukami D, Malcolm RE, Patel MK, Jamerson BD, Dozier G. Zyban (bupropion HCL SR) vs placebo as an aid to smoking reduction among smokers unwilling and unable to quit smoking (PO4 77). In: Society for Research on Nicotine and Tobacco 7th Annual Meeting; 2001 March 23-23; Seattle (WA). 2001:117.
Hawk 2008 {unpublished data only}
    1. Hawk LW, Mahoney MC, Ashare RL, Rhodes JD, Oliver JA, Cummings KM, et al. Preliminary evidence of extinction of smoking behavior with bupropion (PA9-4). In: Society for Research on Nicotine and Tobacco 14th Annual Meeting; 2008 February 26-March 1; Portland (OR). 2008.
Hawk 2015 {published data only}
    1. Hawk LW Jr, Ashare RL, Rhodes JD, Oliver JA, Cummings KM, Mahoney M. Does extended pre quit bupropion aid in extinguishing smoking behavior? Nicotine & Tobacco Research 2015;17(11):1377-84. - PMC - PubMed
Hays 2001 {published data only}
    1. Abel GA, Hays JT, Decker PA, Croghan GA, Kuter DJ, Rigotti NA. Effects of biochemically confirmed smoking cessation on white blood cell count. Mayo Clinical Proceedings 2005;80:1022-8. - PubMed
    1. Cox LS, Patten CA, Niaura RS, Decker PA, Rigotti N, Sachs DP, et al. Efficacy of bupropion for relapse prevention in smokers with and without a past history of major depression. Journal of General Internal Medicine 2004;19:828-34. - PMC - PubMed
    1. Durcan MJ, Deener G, White J, Johnston JA, Gonzales D, Niaura R, et al. The effect of bupropion sustained-release on cigarette craving after smoking cessation. Clinical Therapeutics 2002;24:540-51. - PubMed
    1. Durcan MJ, Johnston JA, White J, Gonzales D, Sachs DP, Rigotti N, et al. Bupropion SR for relapse prevention: a "slips-allowed" analysis. American Journal of Health Behavior 2004;28(5):456-63. - PubMed
    1. Gonzales D, Bjornson W, Durcan MJ, White JD, Johnston JA, Buist AS, et al. Effects of gender on relapse prevention in smokers treated with bupropion SR. American Journal of Preventive Medicine 2002;22:234-39. - PubMed
Hays 2009 {published data only}
    1. Hays JT, Hurt RD, Decker PA, Croghan IT, Offord KP, Patten CA. A randomized, controlled trial of bupropion sustained-release for preventing tobacco relapse in recovering alcoholics. Nicotine & Tobacco Research 2009;11(7):859-67. 9400123000005366 - PMC - PubMed
Hilberink 2005 {published data only}
    1. Hilberink SR, Jacobs JE, Breteler MH, Vries H, Grol RP. General practice counseling for patients with chronic obstructive pulmonary disease to quit smoking: Impact after 1 year of two complex interventions. Patient Education and Counseling 2011;83(1):120-4. 9400123000005920 - PubMed
Hitsman 1999 {published data only}
    1. Hitsman B, Pingitore R, Spring B, Mahableshwarkar A, Mizes JS, Segraves KA, et al. Antidepressant pharmacotherapy helps some cigarette smokers more than others. Journal of Consulting and Clinical Psychiatry 1999;67:547-54. - PubMed
    1. Hitsman B, Spring B, Borrelli B, Niaura R, Papandonatos G. Adherence to medication versus behavioral therapy as predictors of smoking cessation in combined treatment involving fluoxetine [abstract]. Society for Research on Nicotine and Tobacco Annual Conference; 2000 Feb 18-20; Arlington (VA) 2000.
Houtsmuller 2002 {published data only}
    1. Houtsmuller EJ, Stitzer ML. Selegiline effects on smoking and abstinence [abstract]. CPDD Annual Meeting; 1998 June 12-17; Scottsdale (AZ) 1998.
    1. Houtsmuller EJ, Thornton JA, Stitzer ML. Effects of selegiline (l-deprenyl) during smoking and short-term abstinence. Psychopharmacology (Berl) 2002;163:213-20. - PubMed
Hurt 2003 {published and unpublished data}
    1. Hurt RD, Croghan GA, Sloan JA, Krook JE, Silberstein PT. Bupropion for relapse prevention after nicotine patch therapy [PA 5B abstract ]. In: Society for Research on Nicotine and Tobacco 7th Annual Meeting; 2001 March 23-23; Seattle (WA). 2001:32.
    1. Hurt RD, Krook JE, Croghan IT, Loprinzi CL, Sloan JA, Novotny PJ, et al. Nicotine patch therapy based on smoking rate followed by bupropion for prevention of relapse to smoking. Journal of Clinical Oncology 2003;21:914-20. - PubMed
Hussain 2010 {published data only}
    1. Hussain S, Zawertailo L, Busto U, Zack M, Farvolden P, Selby P. The impact of chronic bupropion on plasma cotinine and on the subjective effects of ad lib smoking: a randomized controlled trial in unmotivated smokers. Addictive Behaviors 2010;35(2):164-7. 9400123000005919 - PubMed
Isgro 2015 {published data only}
    1. Isgro M, Doran N, Heffner JL, Bekman N, Wong E, Tibbs J. Type a/type b alcoholism predicts differential response to topiramate in a smoking cessation trial in dually-diagnosed men. Alcoholism: Clinical and Experimental Research 2015;39(Suppl 1):76A.
Jacobs 1971 {published data only}
    1. Jacobs MA, Spilken AZ, Norman MM, Wohlberg GW, Knapp PH. Interaction of personality and treatment conditions associated with success in a smoking control program. Psychosomatic Medicine 1971;33(6):545-56. - PubMed
Kalman 2004 {unpublished data only}
    1. Kalman D, Engler P, Monti P. Preliminary findings from a pilot treatment study of smokers in early alcohol recovery (POS1-072). In: Society for Research on Nicotine and Tobacco 10th Annual Meeting; 2004 February 18-21, Phoenix (AZ). 2004.
Khunrong 2016 {published data only}
    1. Khunrong P, Sittipunt C. Comparison of efficacy of varenicline and nortriptyline - short-term smoking cessation in outpatient setting. European Respiratory Journal 2016;48(60):4601.
Killen 2006 {published data only}
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References to ongoing studies

NCT03326128 {published data only}
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