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Review
. 2020 Sep;77(3):340-350.
doi: 10.1111/his.14120. Epub 2020 Jul 4.

Gastrointestinal tissue-based molecular biomarkers: a practical categorisation based on the 2019 World Health Organization classification of epithelial digestive tumours

Javier I Quezada-Marín  1   2 , Alfred K Lam  3 , Atsushi Ochiai  4 , Robert D Odze  5 , Kay M Washington  6 , Masashi Fukayama  7 , Massimo Rugge  8 , David S Klimstra  9 , Iris D Nagtegaal  10 , Puay-Hoon Tan  11 , Mark J Arends  12 , John R Goldblum  13 , Ian A Cree  14 , Manuel Salto-Tellez  1   15
Affiliations
Review

Gastrointestinal tissue-based molecular biomarkers: a practical categorisation based on the 2019 World Health Organization classification of epithelial digestive tumours

Javier I Quezada-Marín et al. Histopathology. 2020 Sep.

Abstract

Molecular biomarkers have come to constitute one of the cornerstones of oncological pathology. The method of classification not only directly affects the manner in which patients are diagnosed and treated, but also guides the development of drugs and of artificial intelligence tools. The aim of this article is to organise and update gastrointestinal molecular biomarkers in order to produce an easy-to-use guide for routine diagnostics. For this purpose, we have extracted and reorganised the molecular information on epithelial neoplasms included in the 2019 World Health Organization classification of tumours. Digestive system tumours, 5th edn.

Keywords: WHO; biomarkers; gastrointestinal neoplasms; genomics; molecular pathology.

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References

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