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Review
. 2020 Oct:66:22-26.
doi: 10.1016/j.coi.2020.03.012. Epub 2020 Apr 19.

Microbiota-immune interactions in asthma pathogenesis and phenotype

Nicholas W Lukacs  1 , Yvonne J Huang  2
Affiliations
Review

Microbiota-immune interactions in asthma pathogenesis and phenotype

Nicholas W Lukacs et al. Curr Opin Immunol. 2020 Oct.

Abstract

The complexity and the mechanistic role of microbial communities at mucosal surfaces are only now beginning to be understood. Their impact on host metabolism, development, and immune responses to infectious and inert stimuli may be centrally linked to the metabolic functions of these communities within the established microbiome. The structure and function of microbial communities are influenced both early and throughout life by many environmental factors, exposures, diet, and disease. Understanding how the microbiome influences the host during health is likely just as important as understanding how it influences asthmatic disease predisposition and severity.

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Conflict of interest statement

Declaration of interest

Nothing declared.

Figures

Figure 1
Figure 1
Dynamic factors with plausible links to the host microbiota that are associated with asthma pathogenesis or asthmatic phenotype. Mechanisms are understood for some but not all interactions.
See this image and copyright information in PMC

References

    1. Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV et al.: After asthma: redefining airways diseases. Lancet 2018, 391:350–400 - PubMed

    2. A thorough authoritative and transformative discussion on approaches to asthma diagnosis, management and scientific research, that calls for a radical shift in the conceptualization of asthma to advance therapeutic or preventative strategies.

    1. Penders J, Thijs C, van den Brandt PA, Kummeling I, Snijders B, Stelma F et al.: Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut 2007, 56:661–667. - PMC - PubMed
    1. Kraft M, Cassell GH, Henson JE, Watson H, Williamson J, Marmion BP et al.: Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am J Respir Crit Care Med 1998, 158:998–1001. - PubMed
    1. Bisgaard H, Hermansen MN, Buchvald F, Loland L, Halkjaer LB, Bonnelykke K et al.: Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007, 357:1487–1495. - PubMed
    1. Kloepfer KM, Lee WM, Pappas TE, Kang TJ, Vrtis RF, Evans MD et al.: Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations. J Allergy Clin Immunol 2014, 133:1301–1307 1307.e1–3. - PMC - PubMed

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