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Editorial
. 2020 Jul;30(7):481-485.
doi: 10.1080/13543776.2020.1760838. Epub 2020 Apr 29.

A deadly spillover: SARS-CoV-2 outbreak

Mattia Mori  1 , Clemente Capasso  2 , Fabrizio Carta  3 , William A Donald  4 , Claudiu T Supuran  3
Affiliations
Editorial

A deadly spillover: SARS-CoV-2 outbreak

Mattia Mori et al. Expert Opin Ther Pat. 2020 Jul.
No abstract available

Keywords: Corona virus; antiviral; covid-19; protease inhibitor.

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Figures

Figure 1.
Figure 1.
Open reading frame 1 (ORF1) genomic organization of SARS-CoV-2. In the orange boxes, the four enzymes that might be targeted by antiviral drugs: papain-like protease (PLP), main protease (MP), RNA-dependent RNA polymerase (RdRp) and helicase.
Figure 2.
Figure 2.
Alignment of the PLPs from the three CoV. Multiple amino acid sequence alignment was performed with the program ClustalW, version 2.1. The alignment was formatted highlighting in black the identical residues and the conservative substitutions in gray.
Figure 3.
Figure 3.
Multiple amino acid sequence alignment of the MPs from SARS-CoV, MERS-CoV, and SARS-CoV-2 carried out with ClustalW, version 2.1. The formatted alignment shows the identical amino acid residues (black) and the conservative substitutions (gray).
Figure 4.
Figure 4.
Drugs and drug candidates with some efficacy against SARS-CoV-2.
See this image and copyright information in PMC

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