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Comparative Study
. 1977 Apr;130(1):187-91.
doi: 10.1128/jb.130.1.187-191.1977.

Repair of hydrogen peroxide-induced single-strand breaks in Escherichia coli deoxyribonucleic acid

H N Ananthaswamy, A Eisenstark
Comparative Study

Repair of hydrogen peroxide-induced single-strand breaks in Escherichia coli deoxyribonucleic acid

H N Ananthaswamy et al. J Bacteriol. 1977 Apr.

Abstract

Near-ultraviolet (300 to 400 nm) irradiation of L-tryptophan yielded H2O2 (a toxic photoproduct) that was selectively lethal for rec and polA1 Escherichia coli mutants. H2O2 treatment of cells resulted in the induction of single-strand deoxyribonucleic acid breaks. These breaks were repaired to only a small extent in polA1, recA recB, and recA mutants, but were efficiently repaired in wild-type strains. We conclude that H2O2 deoxyribonucleic acid lesions require both the polA+ and recA+ pathways for repair.

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