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Review
. 2020:1238:23-37.
doi: 10.1007/978-981-15-2385-4_3.

Gut Microbiota and Liver Injury (I)-Acute Liver Injury

Guangyan Wu  1 , Sanda Win  2 , Tin A Than  2 , Peng Chen  1 , Neil Kaplowitz  3
Affiliations
Review

Gut Microbiota and Liver Injury (I)-Acute Liver Injury

Guangyan Wu et al. Adv Exp Med Biol. 2020.

Abstract

Over the last few decades, intestinal microbial communities have been considered to play a vital role in host liver health. Acute liver injury (ALI) is the manifestation of sudden hepatic injury and arises from a variety of causes. The studies of dysbiosis in gut microbiota provide new insight into the pathogenesis of ALI. However, the relationship of gut microbiota and ALI is not well understood, and the contribution of gut microbiota to ALI has not been well characterized. In this chapter, we integrate several major pathogenic factors in ALI with the role of gut microbiota to stress the significance of gut microbiota in prevention and treatment of ALI.

Keywords: Acute liver injury; DILI; Gut microbiota.

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