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. 2021 Nov;35(21):3999-4004.
doi: 10.1080/14786419.2020.1753055. Epub 2020 Apr 23.

A new phenylheptanoid from the leaves of Gnetum gnemon L

Tho Huu Le  1   2 , Truong Nhat Van Do  1   2 , Hai Xuan Nguyen  1   2 , Phu Hoang Dang  1   2 , Nhan Trung Nguyen  1   2   3 , Mai Thanh Thi Nguyen  1   2   3
Affiliations

A new phenylheptanoid from the leaves of Gnetum gnemon L

Tho Huu Le et al. Nat Prod Res. 2021 Nov.

Abstract

Phytochemical study on the EtOAC-soluble extract of the leaves of Gnetum gnemon furnished the isolation of a new phenylheptanoid, gnetumal (1), along with five known compounds (2-6). Their isolation was carried out by using the column chromatography and their structures were elucidated based on the basis of the spectral interpretation. Bioactivity assay of these compounds indicated that gnetumal (1) and p-coumaric acid (5) possessed more potent tyrosinase inhibitory activity, with IC50 values of 31.6 and 2.3 µM, respectively, than that of a positive control kojic acid (IC50; 44.6 µM).

Keywords: Gnetaceae; Gnetum gnemon L.; phenylheptanoid; tyrosinase inhibitory.

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