Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy

Yuka Asai¹, David Martino^{2

3}, Thomas Eiwegger⁴, Kari Nadeau⁵, Gerard H Koppelman⁶, Ann E Clarke⁷, Young-Ae Lee⁸, Edmond S Chan⁹, Elinor Simons¹⁰, Catherine Laprise¹¹, Bruce Mazer¹², Ingo Marenholz⁸, Diana Royce¹³, Susan J Elliott¹⁴, Christine Hampson¹⁵, Jennifer Gerdts¹⁶, Aida Eslami¹⁷, Lianne Soller⁹, Jennie Hui¹⁸, Meghan Azad¹⁹, Andrew Sandford²⁰, Denise Daley²⁰

Affiliations

¹ Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
² Telethon Kids Institute, Perth, Western Australia, Australia.
³ Centre for Food and Allergy Research, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
⁴ Department of Paediatrics, Division of Clinical Immunology and Allergy, Food allergy and Anaphylaxis Program, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.
⁵ Pediatrics, Stanford University, Stanford, CA, USA.
⁶ Department of Pediatric Pulmonology and Pediatric Allergology, and Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
⁷ Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
⁸ Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, and Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
⁹ BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
¹⁰ Pediatrics & Child Health, Section of Allergy & Clinical Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
¹¹ Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.
¹² Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
¹³ AllerGen NCE, Hamilton, Ontario, Canada.
¹⁴ Applied Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
¹⁵ The Sandbox Project, Toronto, Ontario, Canada.
¹⁶ Food Allergy Canada, Toronto, Ontario, Canada.
¹⁷ Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Quebec, Quebec, Canada.
¹⁸ School of Population Health, University of Western Australia, Perth, Western Australia, Australia.
¹⁹ Pediatrics, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
²⁰ Department of Medicine, The University of British Columbia Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada.

PMID: 32323869
PMCID: PMC7540469
DOI: 10.1111/all.14333

Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy

Yuka Asai et al. Allergy. 2020 Sep.

. 2020 Sep;75(9):2383-2387.

doi: 10.1111/all.14333. Epub 2020 Jul 6.

Authors

Affiliations

¹ Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
² Telethon Kids Institute, Perth, Western Australia, Australia.
³ Centre for Food and Allergy Research, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
⁴ Department of Paediatrics, Division of Clinical Immunology and Allergy, Food allergy and Anaphylaxis Program, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.
⁵ Pediatrics, Stanford University, Stanford, CA, USA.
⁶ Department of Pediatric Pulmonology and Pediatric Allergology, and Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
⁷ Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
⁸ Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, and Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
⁹ BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
¹⁰ Pediatrics & Child Health, Section of Allergy & Clinical Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
¹¹ Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.
¹² Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
¹³ AllerGen NCE, Hamilton, Ontario, Canada.
¹⁴ Applied Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
¹⁵ The Sandbox Project, Toronto, Ontario, Canada.
¹⁶ Food Allergy Canada, Toronto, Ontario, Canada.
¹⁷ Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Quebec, Quebec, Canada.
¹⁸ School of Population Health, University of Western Australia, Perth, Western Australia, Australia.
¹⁹ Pediatrics, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
²⁰ Department of Medicine, The University of British Columbia Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada.

PMID: 32323869
PMCID: PMC7540469
DOI: 10.1111/all.14333

No abstract available

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Figures

**Figure 1**
A, Proposed groups of food allergy phenotypes for genetic research. B, Summary of factors involved in development of food allergy

See this image and copyright information in PMC

References

1. Asai Y, Eslami A, van Ginkel CD, et al. Genome‐wide association study and meta‐analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. J Allergy Clin Immunol. 2018;141(3):991‐1001. - PubMed
1. Marenholz I, Grosche S, Kalb B, et al. Genome‐wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy. Nat Commun. 2017;8(1):1056. - PMC - PubMed
1. Martino DJ, Ashley S, Koplin J, et al. Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA‐DRB1. Clin Exp Allergy. 2017;47(2):217‐223. - PubMed
1. Simons FE, Ardusso LR, Bilo MB, et al. World allergy organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J. 2011;4(2):13‐37. - PMC - PubMed
1. Astier C, Morisset M, Roitel O, et al. Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy. J Allergy Clin Immunol. 2006;118(1):250‐256. - PubMed

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Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy

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Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy

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