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. 2020 Jun;25(6):956-958.
doi: 10.1016/j.drudis.2020.04.010. Epub 2020 Apr 20.

Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

Thomas J Manning  1 , Jenu Thomas-Richardson  2 , Matthew Cowan  2 , Torien Beard  2
Affiliations

Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

Thomas J Manning et al. Drug Discov Today. 2020 Jun.

Abstract

This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.

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Graphical abstract
Fig. 1
Fig. 1
The structure of bryostatin-1 has a bryophan ring and R1 (C8) and R2 (C2) functional groups.
See this image and copyright information in PMC

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