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Editorial
. 2020 Apr 15;9(4):1126.
doi: 10.3390/jcm9041126.

COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression

Florence Carrouel  1 , Maria Pia Conte  2 , Julian Fisher  3 , Lucio Souza Gonçalves  4 , Claude Dussart  5 , Juan Carlos Llodra  6 , Denis Bourgeois  1
Affiliations
Editorial

COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression

Florence Carrouel et al. J Clin Med. .

Abstract

Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression.

Keywords: 2019-nCoV; COVID-19; Citrox; SARS-CoV-2; microbiome; mouthrinse; oral cavity; viral load; β-cyclodextrins.

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Conflict of interest statement

The authors declare no conflict of interest.

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