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. 2020 Sep;6(9):732-736.
doi: 10.1016/j.trecan.2020.03.008. Epub 2020 Apr 20.

Cell Competition Spurs Selection of Aggressive Cancer Cells

Taylor Parker  1 , Esha Madan  1 , Kartik Gupta  2 , Eduardo Moreno  3 , Rajan Gogna  4
Affiliations

Cell Competition Spurs Selection of Aggressive Cancer Cells

Taylor Parker et al. Trends Cancer. 2020 Sep.

Abstract

Within heterogeneous tumors, cancer cells are constantly interacting. Cell competition (CC) is a fitness-based selection mechanism that results in increased proliferation of discrete populations at the expense of their less fit neighbors. CC-based selection of fit cells may also drive selection of the most aggressive cancer cells.

Keywords: Col17A; Flower; Hippo; JAK/STAT; Myc; Tead; cell competition; p53; tumor heterogeneity.

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