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Comment
. 2020 Apr 24;368(6489):369-370.
doi: 10.1126/science.abb4393.

Calcium as a biased cofactor

Madhu Chaturvedi  1 , Arun K Shukla  2
Affiliations
Comment

Calcium as a biased cofactor

Madhu Chaturvedi et al. Science. .
No abstract available

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Figures

Figure
Figure. Calcium binding influences hunger signaling
Melanocortin-4 receptor (MC4R) is expressed primarily in the hypothalamus and brainstem. It binds to two different neuropeptides, α-melanocyte–stimulating hormone [α-MSH, from proopiomelanocortin (POMC) neurons] and agouti-related protein (AgRP), which exert opposing effects on downstream responses. A crystal structure of MC4R in complex with the cyclic peptide antagonist, SHU9119, revealed a Ca2+-binding site that influences downstream signaling.
See this image and copyright information in PMC

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