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. 2020 Apr 6:2020:4503919.
doi: 10.1155/2020/4503919. eCollection 2020.

Model-Based Weaning Tests for VA-ECLS Therapy

Simon Habran  1 , Thomas Desaive  1 , Philippe Morimont  1 , Bernard Lambermont  2 , Pierre C Dauby  1
Affiliations

Model-Based Weaning Tests for VA-ECLS Therapy

Simon Habran et al. Comput Math Methods Med. .

Abstract

Venoarterial extracorporeal life support (VA-ECLS) is used in ICUs (intensive care units) for the most extreme presentations of acute and severe cardiogenic shock, and one of the main issues the clinicians have to deal with is the weaning from VA-ECLS. In this study, a patient-specific model of the cardiovascular system connected to a VA-ECLS is built to improve the understanding of this complex system. Pig experiments are performed to validate the model, and the results are quite promising since the mean difference between experimental data and simulation is smaller than 5% for all the hemodynamic quantities. It is also a major objective of this paper to provide a proof-of-concept analysis that model-based approaches could improve the weaning strategy for VA-ECLS therapy.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Model of the cardiovascular system connected to a VA-ECLS. All symbols are defined in the text.
Figure 2
Figure 2
Heart rate in terms of Qd for the weaning tests Pig8 T1 and Pig8 T2.
Figure 3
Figure 3
Comparison between experimental and simulated maxT(Vh), P¯a, P¯v, SV, and PPa in terms of Qd for the weaning test Pig8 T1 and Pig8 T2.
Figure 4
Figure 4
Values of Δ1Eh/Eh, Δ1SBV/SBV, Δ1Ah/Ah, Δ1Ea/Ea, and Δ1Rs/Rs for each weaning test.
Figure 5
Figure 5
Comparison between experimental (crosses) and simulated (solid, dashed, and dotted lines) hemodynamic quantities in terms of Qd. “Sim. 1” and “Sim. 2” refer to our simulations with, respectively, Qd-independent and Qd-dependent physiological parameters, while “Brommé and Donker” indicates the results of the simulations in [5]. “Exp” refers to the experimental data of [22].
See this image and copyright information in PMC

References

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