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Review
. 2020 Apr 6;11(13):3976-3985.
doi: 10.7150/jca.42734. eCollection 2020.

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma

Yutong Tian  1   2 , Lu Tang  1   2 , Pin Yi  1   2 , Qing Pan  1   2 , Yaqian Han  1 , Yingrui Shi  1 , Shan Rao  1 , Shiming Tan  1 , Longzheng Xia  1 , Jinguan Lin  1 , Linda Oyang  1 , Yanyan Tang  1 , Jiaxin Liang  1 , Xia Luo  1 , Qianjin Liao  1 , Hui Wang  1 , Yujuan Zhou  1
Affiliations
Review

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma

Yutong Tian et al. J Cancer. .

Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck in Southeast Asia and southern China. Although the comprehensive treatment based on intensity-modulated radiation therapy improves outcomes, the five-year survival rate of NPC patients is low, and the recurrence remains high. Radiotherapy resistance is the main cause of poor prognosis in NPC patients. MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs regulating various biological functions in eukaryotes. These miRNAs can regulate the development and progression of nasopharyngeal carcinoma by affecting the proliferation, apoptosis, movement, invasion and metastasis of NPC cells. The abnormal expression of miRNAs is closely related to radiotherapy sensitivity and prognosis of NPC patients, which can affect the transmission of related signaling pathways by regulating the expression of tumor suppressor genes and / or oncogenes, and therefore participate in radiotherapy resistance in nasopharyngeal carcinoma. Here, we review the mechanisms by which miRNAs may be involved in the radiotherapy resistance of nasopharyngeal carcinoma.

Keywords: apoptosis; miR-BARTs; miRNAs; nasopharyngeal carcinoma; radiotherapy resistance.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Schematic diagram of miRNAs that regulate radiotherapy resistance by Bcl-2, Caspase and Fas apoptosis families in nasopharyngeal carcinoma.
See this image and copyright information in PMC

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