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. 2020 May;295 Suppl s1(Suppl 1):4-10.
doi: 10.1111/imr.12857. Epub 2020 Apr 23.

Application of a portable instrument for rapid and reliable detection of SARS-CoV-2 infection in any environment

Federico Martinelli  1 , Anna Perrone  2 , Isabella Della Noce  3 , Lorenzo Colombo  3 , Stefano Lo Priore  3 , Simone Romano  3
Affiliations

Application of a portable instrument for rapid and reliable detection of SARS-CoV-2 infection in any environment

Federico Martinelli et al. Immunol Rev. 2020 May.

Abstract

The ongoing outbreak of the novel coronavirus (SARS-CoV-2) infection is creating serious challenges for health laboratories that seek to identify viral infections as early as possible, optimally at the earliest appearance of symptom. Indeed, there is urgent need to develop and deploy robust diagnostic methodologies not only to use in health laboratory environments but also directly in places where humans circulate and spread the virus such as airports, trains, boats, and any public aggregation places. The success of a reliable and sensitive asymptomatic diagnosis relies on the identification and measurement of informative biomarkers from human host and virus in a rapid, sensitive, and inexpensive manner. The objective of this article is to describe an innovative multidisciplinary approach to develop an efficient, inexpensive, and easy-to-use portable instrument (bCUBE® by Hyris Ltd) that can be employed as a surveillance system for the emergency caused by SARS-CoV-2. A solution for Coronavirus testing, compliant with CDC guidelines, is scheduled to be released in the next weeks. In addition, we will describe a workflow and path of an integrated multi-omic approach that will lead to host and pathogen biomarker discovery in order to train the instrument to provide reliable results based on a specific biomarker's fingerprint of SARS-CoV-2 infection.

Keywords: SARS-CoV-2 detection; coronavirus; device; instrument; portable.

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Conflict of interest statement

We certify that Lorenzo Colombo, Stefano Lo Priore, Isabella Della Noce and Simone Romano are employees of Hyris Ltd. that produces the bCUBE® instrument described in this article.

Figures

FIGURE 1
FIGURE 1
Steps of current coronavirus primary screening
FIGURE 2
FIGURE 2
Components of Hyris platform: bCUBE®, bAPP, bKit, and starter kit
FIGURE 3
FIGURE 3
Additional details of the components of the portable system
FIGURE 4
FIGURE 4
Typical workflow for the use of bCUBE® for detection of pathogens from DANN extraction to results readout
FIGURE 5
FIGURE 5
Possible workflow of Coronavirus secondary screening using bCUBE® portable instrument
See this image and copyright information in PMC

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