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Review
. 2020 Jun;35(3):386-405.
doi: 10.1002/ncp.10490. Epub 2020 Apr 24.

Early-Life Gut Microbiome-The Importance of Maternal and Infant Factors in Its Establishment

Fatemeh Ramezani Kapourchali  1 , Gail A M Cresci  1   2   3
Affiliations
Review

Early-Life Gut Microbiome-The Importance of Maternal and Infant Factors in Its Establishment

Fatemeh Ramezani Kapourchali et al. Nutr Clin Pract. 2020 Jun.

Abstract

The early-life microbiome is gaining appreciation as a major influencer in human development and long-term health. Multiple factors are known to influence the initial colonization, development, and function of the neonatal gut microbiome. In addition, alterations in early-life gut microbial composition is associated with several chronic health conditions such as obesity, asthma, and allergies. In this review, we focus on both maternal and infant factors known to influence early-life gut colonization. Also reviewed is the important role of infant feeding, including evidence-based strategies for maternal and infant supplementation with the goal to protect and/or restore the infant gut microbiome.

Keywords: asthma; developmental disabilities; gastrointestinal microbiome; human milk; infant formula; microbiota; obesity; pediatrics; prebiotics.

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References

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