Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine

Alexis Mathian¹, Matthieu Mahevas², Julien Rohmer³, Mathilde Roumier³, Fleur Cohen-Aubart⁴, Blanca Amador-Borrero⁵, Audrey Barrelet⁶, Cecile Chauvet⁷, Thibaud Chazal⁴, Michel Delahousse⁸, Mathilde Devaux⁹, Romain Euvrard¹⁰, Jehane Fadlallah⁴, Nans Florens¹¹, Julien Haroche⁴, Miguel Hié⁴, Laurent Juillard¹¹, Raphael Lhote^{4

12}, Thibault Maillet¹³, Gaelle Richard-Colmant¹⁴, Jean Baptiste Palluy¹⁰, Micheline Pha⁴, Laurent Perard¹⁵, Philippe Remy¹⁶, Etienne Rivière¹⁷, Damien Sène⁵, Pascal Sève¹⁴, Capucine Morélot-Panzini¹⁸, Jean-François Viallard¹⁷, Jean-Simon Virot¹⁹, Neila Benameur²⁰, Noël Zahr²¹, Hans Yssel²², Bertrand Godeau², Zahir Amoura⁴

Affiliations

¹ Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France alexis.mathian@aphp.fr.
² Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Service de Médecine Interne, Paris, France.
³ Service de Médecine Interne, Hôpital Foch, Suresnes, France.
⁴ Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
⁵ Université de Paris (Paris-Diderot), Assistance Publique-Hôpitaux de Paris, Département de Médecine Interne et d'Immunologie Clinique Hôpital Lariboisière, Paris, France.
⁶ Service de Maladies Infectieuses et Tropicales, Grand Hôpital de l'Est Francilien - Site de Marne-la-Vallée, Jossigny, France.
⁷ Service de Néphrologie, Hôpital Saint-Joseph-Saint-Luc, Lyon, France.
⁸ Service de Néphrologie, Hôpital Foch, Suresnes, France.
⁹ Service de Médecine Interne, CHI Poissy Saint Germain, Poissy, France.
¹⁰ Service de réanimation polyvalente, Centre Hospitalier Fleyriat, Bourg-en-Bresse, France.
¹¹ Université Lyon 1, Hospices Civils de Lyon, Hôpital Edouard Herriot, CarMeN - UMR INSERM U.1060, Service de néphrologie, hypertension, hémodialyse et explorations fonctionnelles rénales, Lyon, France.
¹² Sorbonne Université, UPMC, Institut Pierre Louis d'Epidémiologie et de Santé Public (IPLESP), UMRS 1136, Epidémiologie des Pathologies Allergique et Respiratoire (EPAR), Faculté de médecine de Saint Antoine, Paris, France.
¹³ Service de Médecine Interne - Unité 11, Centre Hospitalier de Mâcon, Groupe Hospitalier Bourgogne Méridionale, Macon, France.
¹⁴ Service de Médecine Interne, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
¹⁵ Service de Médecine interne, Hôpital Saint-Joseph-Saint-Luc, Lyon, France.
¹⁶ Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Service de Néphrologie, Paris, France.
¹⁷ Internal Medicine Department, Hôpital Haut-Lévêque, Bordeaux University Hospital, Avenue de Magellan, Pessac, France.
¹⁸ Sorbonne Université, INSERM, UMRS1158; AP-HP, Groupe Hospitalier Universitaire APHP Sorbonne Université, site Pitié-Salpêtrière, Service de Pneumologie et Réanimation Médicale (Département R3S), Paris, France.
¹⁹ Service de service de Néphrologie/Dialyse, Centre Hospitalier de Mâcon, Groupe Hospitalier Bourgogne Méridionale, Macon, France.
²⁰ Service De La Pharmacie, Assistance Publique-Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, Paris, France.
²¹ Service De Pharmacologie, Assistance Publique-Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, Paris, France.
²² Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.

PMID: 32332072
DOI: 10.1136/annrheumdis-2020-217566

Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine

Alexis Mathian et al. Ann Rheum Dis. 2020 Jun.

. 2020 Jun;79(6):837-839.

doi: 10.1136/annrheumdis-2020-217566. Epub 2020 Apr 24.

Authors

Affiliations

¹ Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France alexis.mathian@aphp.fr.
² Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Service de Médecine Interne, Paris, France.
³ Service de Médecine Interne, Hôpital Foch, Suresnes, France.
⁴ Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
⁵ Université de Paris (Paris-Diderot), Assistance Publique-Hôpitaux de Paris, Département de Médecine Interne et d'Immunologie Clinique Hôpital Lariboisière, Paris, France.
⁶ Service de Maladies Infectieuses et Tropicales, Grand Hôpital de l'Est Francilien - Site de Marne-la-Vallée, Jossigny, France.
⁷ Service de Néphrologie, Hôpital Saint-Joseph-Saint-Luc, Lyon, France.
⁸ Service de Néphrologie, Hôpital Foch, Suresnes, France.
⁹ Service de Médecine Interne, CHI Poissy Saint Germain, Poissy, France.
¹⁰ Service de réanimation polyvalente, Centre Hospitalier Fleyriat, Bourg-en-Bresse, France.
¹¹ Université Lyon 1, Hospices Civils de Lyon, Hôpital Edouard Herriot, CarMeN - UMR INSERM U.1060, Service de néphrologie, hypertension, hémodialyse et explorations fonctionnelles rénales, Lyon, France.
¹² Sorbonne Université, UPMC, Institut Pierre Louis d'Epidémiologie et de Santé Public (IPLESP), UMRS 1136, Epidémiologie des Pathologies Allergique et Respiratoire (EPAR), Faculté de médecine de Saint Antoine, Paris, France.
¹³ Service de Médecine Interne - Unité 11, Centre Hospitalier de Mâcon, Groupe Hospitalier Bourgogne Méridionale, Macon, France.
¹⁴ Service de Médecine Interne, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
¹⁵ Service de Médecine interne, Hôpital Saint-Joseph-Saint-Luc, Lyon, France.
¹⁶ Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Service de Néphrologie, Paris, France.
¹⁷ Internal Medicine Department, Hôpital Haut-Lévêque, Bordeaux University Hospital, Avenue de Magellan, Pessac, France.
¹⁸ Sorbonne Université, INSERM, UMRS1158; AP-HP, Groupe Hospitalier Universitaire APHP Sorbonne Université, site Pitié-Salpêtrière, Service de Pneumologie et Réanimation Médicale (Département R3S), Paris, France.
¹⁹ Service de service de Néphrologie/Dialyse, Centre Hospitalier de Mâcon, Groupe Hospitalier Bourgogne Méridionale, Macon, France.
²⁰ Service De La Pharmacie, Assistance Publique-Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, Paris, France.
²¹ Service De Pharmacologie, Assistance Publique-Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, Paris, France.
²² Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.

PMID: 32332072
DOI: 10.1136/annrheumdis-2020-217566

No abstract available

Keywords: hydroxychloroquine; lupus erythematosus, systemic; lupus nephritis.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Comment in

Are patients with systemic lupus erythematosus at increased risk for COVID-19?
Favalli EG, Gerosa M, Murgo A, Caporali R. Favalli EG, et al. Ann Rheum Dis. 2021 Feb;80(2):e25. doi: 10.1136/annrheumdis-2020-217787. Epub 2020 May 25. Ann Rheum Dis. 2021. PMID: 32451344 No abstract available.
Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus under long-term treatment with hydroxychloroquine'.
Nikpour M, Teh B, Wicks IP, Pellegrini M. Nikpour M, et al. Ann Rheum Dis. 2021 Mar;80(3):e33. doi: 10.1136/annrheumdis-2020-217827. Epub 2020 May 29. Ann Rheum Dis. 2021. PMID: 32471898 No abstract available.
Response to: 'Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus under long-term treatment with hydroxychloroquine'' by Nikpour et al.
Mathian A, Amoura Z. Mathian A, et al. Ann Rheum Dis. 2021 Mar;80(3):e34. doi: 10.1136/annrheumdis-2020-217875. Epub 2020 May 29. Ann Rheum Dis. 2021. PMID: 32471900 No abstract available.
Response to: 'Patients with lupus with COVID-19: University of Michigan experience' by Wallace et al.
Mathian A, Amoura Z. Mathian A, et al. Ann Rheum Dis. 2021 Mar;80(3):e36. doi: 10.1136/annrheumdis-2020-217910. Epub 2020 May 31. Ann Rheum Dis. 2021. PMID: 32475832 No abstract available.
Patients with lupus with COVID-19: University of Michigan experience.
Wallace B, Washer L, Marder W, Kahlenberg JM. Wallace B, et al. Ann Rheum Dis. 2021 Mar;80(3):e35. doi: 10.1136/annrheumdis-2020-217794. Epub 2020 May 31. Ann Rheum Dis. 2021. PMID: 32475835 Free PMC article. No abstract available.
Monitoring of patients with systemic lupus erythematosus during the COVID-19 outbreak.
Holubar J, Le Quintrec M, Letaief H, Faillie JL, Pers YM, Jorgensen C. Holubar J, et al. Ann Rheum Dis. 2021 Apr;80(4):e56. doi: 10.1136/annrheumdis-2020-217919. Epub 2020 Jun 8. Ann Rheum Dis. 2021. PMID: 32513650 No abstract available.
Response to: 'Monitoring of patients with systemic lupus erythematosus during the COVID-19 outbreak' by Holubar et al.
Mathian A, Amoura Z. Mathian A, et al. Ann Rheum Dis. 2021 Apr;80(4):e57. doi: 10.1136/annrheumdis-2020-217988. Epub 2020 Jun 8. Ann Rheum Dis. 2021. PMID: 32513651 No abstract available.
Response to: 'Concerns and needs of patients with systemic lupus erythematosus regarding hydroxychloroquine supplies during the COVID-19 pandemic: results from a patient-centred survey' by Plüß et al.
Mathian A, Amoura Z. Mathian A, et al. Ann Rheum Dis. 2021 Apr;80(4):e53. doi: 10.1136/annrheumdis-2020-218069. Epub 2020 Jul 2. Ann Rheum Dis. 2021. PMID: 32616603 No abstract available.
Concerns and needs of patients with systemic lupus erythematosus regarding hydroxychloroquine supplies during the COVID-19 pandemic: results from a patient-centred survey.
Plüß M, Chehab G, Korsten P. Plüß M, et al. Ann Rheum Dis. 2021 Apr;80(4):e52. doi: 10.1136/annrheumdis-2020-217967. Epub 2020 Jul 2. Ann Rheum Dis. 2021. PMID: 32616604 No abstract available.
Impact of COVID-19 pandemic on patients with SLE: results of a large multicentric survey from India.
Goyal M, Patil P, Pathak H, Santhanam S, Goel A, Sharma V, Pandey A, Gupta N, Jain R, Akerkar S, Das P, Dudam R, Mendiratta N, Pandey BD, Cb M, Singh BK, Kumar S, Nolkha N, Jain S, Jain S, Sharma A, Misra DP. Goyal M, et al. Ann Rheum Dis. 2021 May;80(5):e71. doi: 10.1136/annrheumdis-2020-218013. Epub 2020 Jul 15. Ann Rheum Dis. 2021. PMID: 32669305 No abstract available.
COVID-19 among Malaysian patients with systemic lupus erythematosus on hydroxychloroquine.
Teh CL, Cheong YK, Wan Musa WR, Wan Mohd Akbar SA, Mat Husin N, Gun SC. Teh CL, et al. Ann Rheum Dis. 2021 May;80(5):e69. doi: 10.1136/annrheumdis-2020-218154. Epub 2020 Jul 31. Ann Rheum Dis. 2021. PMID: 32737111 No abstract available.
Presence of antiphospholipid antibodies in COVID-19: a case series study.
Amezcua-Guerra LM, Rojas-Velasco G, Brianza-Padilla M, Vázquez-Rangel A, Márquez-Velasco R, Baranda-Tovar F, Springall R, Gonzalez-Pacheco H, Juárez-Vicuña Y, Tavera-Alonso C, Sanchez-Muñoz F, Hernández-Salas M. Amezcua-Guerra LM, et al. Ann Rheum Dis. 2021 May;80(5):e73. doi: 10.1136/annrheumdis-2020-218100. Epub 2020 Aug 4. Ann Rheum Dis. 2021. PMID: 32753426 No abstract available.
Exacerbation of immune thrombocytopenia triggered by COVID-19 in patients with systemic lupus erythematosus.
Kondo Y, Kaneko Y, Oshige T, Fukui H, Saito S, Okayama M, Kamata H, Ishii M, Hasegawa N, Fukunaga K, Takeuchi T. Kondo Y, et al. Ann Rheum Dis. 2021 May;80(5):e77. doi: 10.1136/annrheumdis-2020-218157. Epub 2020 Aug 5. Ann Rheum Dis. 2021. PMID: 32759254 No abstract available.
Impact of COVID-19 pandemic on hospitalisation of patients with systemic lupus erythematosus (SLE): report from a tertiary hospital during the peak of the pandemic.
Chuah SL, Teh CL, Wan Mohd Akbar SA, Cheong YK, Sachdev Manjit Singh B. Chuah SL, et al. Ann Rheum Dis. 2022 Aug;81(8):e144. doi: 10.1136/annrheumdis-2020-218475. Epub 2020 Aug 11. Ann Rheum Dis. 2022. PMID: 32788397 No abstract available.
Implications of SARS-CoV-2 infection for patients with rheumatic disease.
Lin C, Wang Z, Li J, Xia X, Liu Y, Wang Q. Lin C, et al. Ann Rheum Dis. 2022 Aug;81(8):e152. doi: 10.1136/annrheumdis-2020-218050. Epub 2020 Aug 13. Ann Rheum Dis. 2022. PMID: 32792333 No abstract available.
Antirheumatic drugs, B cell depletion and critical COVID-19: correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine' by Mathian et al.
Notz Q, Meybohm P, Kranke P, Weismann D, Lotz C, Schmalzing M. Notz Q, et al. Ann Rheum Dis. 2022 Nov;81(11):e216. doi: 10.1136/annrheumdis-2020-218778. Epub 2020 Aug 28. Ann Rheum Dis. 2022. PMID: 32859609 No abstract available.
Systemic lupus erythematosus and COVID-19: what we know so far.
Ramirez GA, Moroni L, Della-Torre E, Gerosa M, Beretta L, Bozzolo EP, Dagna L. Ramirez GA, et al. Ann Rheum Dis. 2023 Mar;82(3):e73. doi: 10.1136/annrheumdis-2020-218601. Epub 2020 Aug 28. Ann Rheum Dis. 2023. PMID: 32859611 No abstract available.
Response to 'Impact of COVID-19 pandemic on hospitalisation of patients with systemic lupus erythematosus (SLE): report from a tertiary hospital during the peak of the pandemic' by Chuah et al.
Mathian A, Amoura Z. Mathian A, et al. Ann Rheum Dis. 2022 Aug;81(8):e145. doi: 10.1136/annrheumdis-2020-218487. Epub 2020 Sep 3. Ann Rheum Dis. 2022. PMID: 32883652 No abstract available.
Response to: 'Implications of SARS-CoV-2 infection for patients with rheumatic disease' by Lin et al.
Mathian A, Amoura Z. Mathian A, et al. Ann Rheum Dis. 2022 Aug;81(8):e153. doi: 10.1136/annrheumdis-2020-218404. Epub 2020 Sep 7. Ann Rheum Dis. 2022. PMID: 32895236 No abstract available.
Response to: 'Antirheumatic drugs, B cell depletion and critical COVID-19: correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine by Mathian et al' by Notz et al.
Mathian A, Amoura Z. Mathian A, et al. Ann Rheum Dis. 2022 Nov;81(11):e217. doi: 10.1136/annrheumdis-2020-218795. Epub 2020 Nov 25. Ann Rheum Dis. 2022. PMID: 33239273 No abstract available.
Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine'.
Martelli Júnior H, Marques NP, Marques NCT, Gomes de Lucena E, Martelli DRB, Oliveira EA. Martelli Júnior H, et al. Ann Rheum Dis. 2023 Nov;82(11):e225. doi: 10.1136/annrheumdis-2021-220410. Epub 2021 Apr 21. Ann Rheum Dis. 2023. PMID: 33883160 No abstract available.

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Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine

Affiliations

Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine

Authors

Affiliations

Conflict of interest statement

Comment in

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