Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2020 Apr;99(17):e19774.
doi: 10.1097/MD.0000000000019774.

A prospective observational study to investigate the correlation analysis between neonatal hyperbilirubinemia and deafness gene: Study protocol clinical trial (SPIRIT compliant)

Xiaohui Wu  1   2 , Xingqiang Gao  2 , Gang Li  1 , Qiuxue Cao  1   3 , Yufeng Guo  2 , Haiyan Deng  2 , Yun Zheng  1
Affiliations
Clinical Trial

A prospective observational study to investigate the correlation analysis between neonatal hyperbilirubinemia and deafness gene: Study protocol clinical trial (SPIRIT compliant)

Xiaohui Wu et al. Medicine (Baltimore). 2020 Apr.

Abstract

Introduction: There are many studies on the relationship between serum levels of hyperbilirubinemia and hearing impairment. However, the mechanism of hyperbilirubinemia on auditory impairment is not clear.

Methods and analysis: A total of 1000 children with hyperbilirubinemia who are mainly indirectly elevated bilirubin in the full-term neonatal ward of Xiamen Children's Hospital from March 2020 to September 2020 will be enrolled. Using second-generation high-throughput sequencing technology, 127 deaf-related genes were sequenced from the collected samples. At the same time, physical audiometry was performed on the selected persons and audiometry data were recorded.

Discussion: In this study, we will combine gene sequencing with clinical indications of hyperbilirubinemia to find the loci suitable for high-frequency pathogenic deafness related to hyperbilirubinemia, so as to provide early guidance for deafness gene screening in children with hyperbilirubinemia.

Trial registration: Chinese Clinical trial registry: ChiCTR2000030075.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow chart of study protocol.
See this image and copyright information in PMC

References

    1. Korver AM, Smith RJ, Van Camp G, et al. Congenital hearing loss. Nat Rev Dis Primers 2017;3:16094–16094. - PMC - PubMed
    1. Coenraad S, Goedegebure A, van Goudoever JB, et al. Risk factors for auditory neuropathy spectrum disorder in NICU infants compared to normal-hearing NICU controls. Laryngoscope 2011;121:852–5. - PubMed
    1. Karaca CT, Oysu C, Toros SZ, et al. Is hearing loss in infants associated with risk factors? Evaluation of the frequency of risk factors. Clin Exp Otorhinolaryngol 2014;7:260–3. - PMC - PubMed
    1. Shapiro SM, Nakamura H. Bilirubin and the auditory system. J Perinatol 2001;21 Suppl 1:S52–62. - PubMed
    1. Karabulut B, Sürmeli M, Bozdağ Ş, et al. Effect of hyperbilirubinemia on medial olivocochlear system in newborns. J Int Adv Otol 2019;15:272–6. - PMC - PubMed