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. 2020 Apr;99(17):e19903.
doi: 10.1097/MD.0000000000019903.

Adductor canal block versus periarticular infiltration for pain control following total knee arthroplasty: Study protocol for a randomized controlled trial

Na Yuan  1 , Jun Shi, Chunyan Lin, Jiang Li
Affiliations

Adductor canal block versus periarticular infiltration for pain control following total knee arthroplasty: Study protocol for a randomized controlled trial

Na Yuan et al. Medicine (Baltimore). 2020 Apr.

Expression of concern in

  • Expression of Concern: Study Protocols.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2025 Nov 7;104(45):e46330. doi: 10.1097/MD.0000000000046330. Medicine (Baltimore). 2025. PMID: 41204616 Free PMC article. No abstract available.

Abstract

Background: Periarticular infiltration (PAI) and adductor canal block (ACB) have become popular modes of pain management after total knee arthroplasty. The purpose of our study is to evaluate the efficacy of ACB in comparison with PAI for pain control in patients undergoing primary total knee arthroplasty.

Methods: This study is a prospective, 2-arm, parallel-group, open-label randomized controlled trial that is conducted at a single university hospital in China. A total of 120 patients who meet inclusion criteria are randomized in a ratio of 1:1 to either ACB or PAI group. The primary outcome is visual analog scale score at rest 24 hours after surgery, whereas the secondary outcomes include visual analog scale score at 48 hours after surgery, satisfaction, opioid consumption, and complications. All pain scores are assessed by an independent observer who is blinded to the allocation of groups.

Results: This study has limited inclusion and exclusion criteria and a well-controlled intervention. This clinical trial is expected to provide evidence of better therapy for the pain management after total knee arthroplasty.

Trial registration: This study protocol was registered in Research Registry (researchregistry5410).

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow diagram of the study.
See this image and copyright information in PMC

References

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