Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)

Kun-Ling Shen¹, Yong-Hong Yang², Rong-Meng Jiang³, Tian-You Wang⁴, Dong-Chi Zhao⁵, Yi Jiang⁶, Xiao-Xia Lu⁷, Run-Ming Jin⁸, Yue-Jie Zheng⁹, Bao-Ping Xu¹⁰, Zheng-De Xie¹¹, Zhi-Sheng Liu¹², Xing-Wang Li³, Li-Kai Lin¹³, Yun-Xiao Shang¹⁴, Sai-Nan Shu¹⁵, Yan Bai⁸, Min Lu¹⁶, Gen Lu¹⁷, Ji-Kui Deng¹⁸, Wan-Jun Luo¹⁹, Li-Juan Xiong²⁰, Miao Liu⁶, Yu-Xia Cui²¹, Le-Ping Ye²², Jia-Fu Li²³, Jian-Bo Shao²⁴, Li-Wei Gao¹⁰, Yong-Yan Wang²⁵, Xue-Feng Wang²⁶; China National Clinical Research Center for Respiratory Diseases; National Center for Children’s Health, Beijing, China; Group of Respirology, Chinese Pediatric Society, Chinese Medical Association; Chinese Medical Doctor Association Committee on Respirology Pediatrics; China Medicine Education Association Committee on Pediatrics; Chinese Research Hospital Association Committee on Pediatrics; China Non-government Medical Institutions Association Committee on Pediatrics; China Association of Traditional Chinese Medicine, Committee on Children’s Health and Medicine Research; China News of Drug Information Association, Committee on Children’s Safety Medication; Global Pediatric Pulmonology Alliance

Affiliations

¹ China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. kunlingshen1717@163.com.
² China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. yyh628628@sina.coms.
³ Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
⁴ Center of Hematologic Oncology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
⁵ Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China. zhao_wh2004@hotmail.com.
⁶ Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China.
⁷ Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
⁸ Department of Pediatrics, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
⁹ Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, China.
¹⁰ China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
¹¹ China National Clinical Research Center for Respiratory Diseases, Beijing Institute of Pediatrics, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, 2019RU016, China.
¹² Department of Neurology, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
¹³ Institute of Hospital Management, Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China.
¹⁴ Department of Pediatric Respiratory, Shengjing Hospital of China Medical University, Shenyang, China.
¹⁵ Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
¹⁶ Department of Respiratory Medicine, Children's Hospital of Shanghai, Shanghai, China.
¹⁷ Department of Respiratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou, China.
¹⁸ Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, China.
¹⁹ Office of Infection Management, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
²⁰ Department of Infectious Diseases, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
²¹ Department of Pediatrics, Guizhou Provincial People's Hospital, Guiyang, China.
²² Department of Pediatrics, Peking University First Hospital, Beijing, China.
²³ Department of Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, China.
²⁴ Radiographic Center, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
²⁵ Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
²⁶ Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.

PMID: 32333248
PMCID: PMC7180653
DOI: 10.1007/s12519-020-00362-4

Review

Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)

Kun-Ling Shen et al. World J Pediatr. 2020 Jun.

. 2020 Jun;16(3):232-239.

doi: 10.1007/s12519-020-00362-4. Epub 2020 Apr 24.

Authors

Affiliations

¹ China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. kunlingshen1717@163.com.
² China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. yyh628628@sina.coms.
³ Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
⁴ Center of Hematologic Oncology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
⁵ Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China. zhao_wh2004@hotmail.com.
⁶ Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China.
⁷ Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
⁸ Department of Pediatrics, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
⁹ Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, China.
¹⁰ China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
¹¹ China National Clinical Research Center for Respiratory Diseases, Beijing Institute of Pediatrics, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, 2019RU016, China.
¹² Department of Neurology, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
¹³ Institute of Hospital Management, Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China.
¹⁴ Department of Pediatric Respiratory, Shengjing Hospital of China Medical University, Shenyang, China.
¹⁵ Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
¹⁶ Department of Respiratory Medicine, Children's Hospital of Shanghai, Shanghai, China.
¹⁷ Department of Respiratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou, China.
¹⁸ Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, China.
¹⁹ Office of Infection Management, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
²⁰ Department of Infectious Diseases, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
²¹ Department of Pediatrics, Guizhou Provincial People's Hospital, Guiyang, China.
²² Department of Pediatrics, Peking University First Hospital, Beijing, China.
²³ Department of Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, China.
²⁴ Radiographic Center, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
²⁵ Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
²⁶ Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.

PMID: 32333248
PMCID: PMC7180653
DOI: 10.1007/s12519-020-00362-4

Abstract

In the early February, 2020, we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis, treatment and prevention of coronavirus disease 2019 (COVID-19) in children, which has been published in this journal. With accumulated experiences in the diagnosis and treatment of COVID-19 in children, we have updated the consensus statement and released the second edition recently. The current version in English is a condensed version of the second edition of consensus statement on diagnosis, treatment and prevention of COVID-19 in children. In the current version, diagnosis and treatement criteria have been optimized, and early identification of severe and critical cases is highlighted. The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice. This version of experts consensus will be valuable for better prevention, diagnosis and treatment of COVID-19 in children worldwide.

Keywords: COVID-19; Children; Infection; SARS-CoV-2; Treatment.

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Conflict of interest statement

The authors have no financial of non-financial conflict of interest relevant to this paper to disclose.

References

1. Shen K, Yang Y, Wang T, et al. Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. World J Pediatr. 2020 doi: 10.1007/s12519-020-00343-7. - DOI - PMC - PubMed
1. National Health Commission of the People’s Republic of China. China-World Health Organization joint study report on coronavirus disease 2019 (COVID-19). https://www.nhc.gov.cn/jkj/s3578/202002/87fd92510d094e4b9bad597608f5cc2c.... Accessed 19 Mar 2020.
1. Lu X, Zhang L, Du H, Zhang J, Li Y, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med. 2020 doi: 10.1056/NEJMc2005073. - DOI - PMC - PubMed
1. National Health Commission of the People’s Republic of China. Diagnosis and treatment plan of novel coronavirus pneumonia (Version 7). https://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1.... Accessed 4 Mar 2020.
1. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30076-X. - DOI - PMC - PubMed

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Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)

Affiliations

Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Miscellaneous