Commentary - Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?
- PMID: 32333558
- PMCID: PMC7369037
- DOI: 10.3233/NPM-200444
Commentary - Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?
Keywords: Erythropoietin; neurodevelopmental outcome; pre-oligodendrocytes; prematurity.
Comment on
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Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age.JAMA. 2014 Aug 27;312(8):817-24. doi: 10.1001/jama.2014.9645. JAMA. 2014. PMID: 25157725 Clinical Trial.
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Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants.Brain. 2015 Feb;138(Pt 2):388-97. doi: 10.1093/brain/awu363. Epub 2014 Dec 22. Brain. 2015. PMID: 25534356 Clinical Trial.
References
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- Xiong T, Qu Y, Mu D, Ferriero D. Erythropoietin for neonatal brain injury: Opportunity and challenge. Int J Dev Neurosci. 2011;29:583–91. - PubMed
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- Kinney HC, Volpe JJ. Encephalopathy of prematurity: Neuropathology. In: Volpe JJ, Inder TE, Darras BT, deVries LS, duPlessis AJ, Neil JJ, et al., editors. Volpe’s Neurology of the Newborn Chapter 14, 6th ed Philadelphia, PA: Elsevier; 2018. pp. 389–404.
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- Rees S, Hale N, De Matteo R, Cardamone L, Tolcos M, Loeliger M, et al. Erythropoietin is neuroprotective in a preterm ovine model of endotoxin-induced brain injury. J Neuropathol Exp Neurol. 2010;69:306–19. - PubMed
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