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. 2020 Jul;146(1):203-206.e3.
doi: 10.1016/j.jaci.2020.04.009. Epub 2020 Apr 22.

Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2

Daniel J Jackson  1 , William W Busse  2 , Leonard B Bacharier  3 , Meyer Kattan  4 , George T O'Connor  5 , Robert A Wood  6 , Cynthia M Visness  7 , Stephen R Durham  8 , David Larson  9 , Stephane Esnault  2 , Carole Ober  10 , Peter J Gergen  11 , Patrice Becker  11 , Alkis Togias  11 , James E Gern  2 , Mathew C Altman  12
Affiliations

Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2

Daniel J Jackson et al. J Allergy Clin Immunol. 2020 Jul.
No abstract available

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Figures

Fig 1
Fig 1
ACE2 expression is decreased in the nasal epithelium of children with allergic sensitization (Sens) and allergic asthma. A,ACE2 expression levels in nasal brush samples from 11-year-old children in the URECA cohort according to asthma diagnosis by the age of 10 years, dichotomized as no (–) or yes (+), and IgE sensitization trajectory at the age of 10 years, dichotomized as not/minimally (no/Min) IgE-sensitized (–) or IgE-sensitized (+), showing lower levels of ACE2 in children with atopy and atopic asthma. B,ACE2 expression in URECA children with asthma, subdivided according to the degree of IgE sensitization and demonstrating progressively lower levels of ACE2 according to the degree of IgE sensitization among children with asthma. Those children with both asthma and the highest IgE sensitization had the lowest levels of ACE2 expression. Expression levels are log2-transformed. Shown are median values (horizontal), interquartile ranges (boxes), and 1.5× interquartile range (whiskers). The printed FCs are for the non–log2-transformed expression values to aid in interpretation of the effect sizes.
Fig 2
Fig 2
ACE2 expression is decreased in nasal and bronchial epithelium of individuals with allergy after allergen challenge. A,ACE2 expression was significantly decreased in nasal brush samples from adults in the cohort with allergic rhinitis and cat allergen sensitization both 8 hours after a cat allergen NAC and 8 hours after the second day of a cat allergen EEC (n = 24) (https://www.itntrialshare.org/CATEEC_primary.url). B,ACE2 expression was significantly decreased in bronchial epithelial brush samples from adults with allergic asthma 48 hours after a segmental bronchial allergen challenge (n = 23). Expression levels are log2-transformed. Shown are median values (horizontal), interquartile ranges (boxes), and 1.5× interquartile range (whiskers). The printed FCs are for the non–log2-transformed expression values to aid in interpretation of the effect sizes.
Fig E1
Fig E1
IL-13 stimulation decreases ACE2 expression in nasal and bronchial epithelium. IL-13 stimulation of airway epithelial cells grown in an air-liquid interface decreased ACE2 expression in nasal epithelium (FC = 0.44; P = 5.8E–4; n = 2 per condition) (A) and bronchial epithelium (FC = 0.80; P = 5.1E–3; n = 4 per condition) (B). Shown are mean expression levels (red) and individual points representing biologic replicates.
See this image and copyright information in PMC

Comment in

  • Reply.
    Jackson DJ, Busse WW, Togias A, Gern JE, Altman MC. Jackson DJ, et al. J Allergy Clin Immunol. 2020 Nov;146(5):1214-1215. doi: 10.1016/j.jaci.2020.07.028. Epub 2020 Aug 14. J Allergy Clin Immunol. 2020. PMID: 32828589 Free PMC article. No abstract available.
  • COVID-19: Start with the nose.
    Lipworth B, Chan R, RuiWen Kuo C. Lipworth B, et al. J Allergy Clin Immunol. 2020 Nov;146(5):1214. doi: 10.1016/j.jaci.2020.06.038. Epub 2020 Aug 14. J Allergy Clin Immunol. 2020. PMID: 32828591 Free PMC article. No abstract available.

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