Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Min Li¹, Han Zhou², Chen Yang², Yi Wu², Xuechang Zhou³, Hang Liu⁴, Yucai Wang⁵

Affiliations

¹ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China; Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
² Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
³ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.
⁴ Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: hangliu@ustc.edu.cn.
⁵ Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: yucaiwang@ustc.edu.cn.

PMID: 32333919
DOI: 10.1016/j.jconrel.2020.04.031

Review

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Min Li et al. J Control Release. 2020.

. 2020 Jul 10:323:253-268.

doi: 10.1016/j.jconrel.2020.04.031. Epub 2020 Apr 22.

Authors

Min Li¹, Han Zhou², Chen Yang², Yi Wu², Xuechang Zhou³, Hang Liu⁴, Yucai Wang⁵

Affiliations

¹ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China; Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
² Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
³ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.
⁴ Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: hangliu@ustc.edu.cn.
⁵ Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: yucaiwang@ustc.edu.cn.

PMID: 32333919
DOI: 10.1016/j.jconrel.2020.04.031

Abstract

Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and contain multiple parent bacteria-derived components. Based on the presence of bacterial antigens, pathogen-associated molecular patterns (PAMPs), adhesins, various proteins and the vesicle structure, OMVs have been developed for biomedical applications as bacterial vaccines, adjuvants, cancer immunotherapy agents, drug delivery vehicles, and anti-bacteria adhesion agents. In this review, we analyze the contributions of the structure and composition of OMVs to their applications, summarize the methods used to isolate and characterize OMVs, and highlight recent progress and future perspectives of OMVs in biomedical applications.

Keywords: Adjuvants; Anti-bacteria adhesion agents; Bacterial vaccines; Cancer immunotherapy agents; Drug delivery vehicles; Outer membrane vesicles.

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Conflict of interest statement

Declaration of Competing Interest The authors declared that they have no conflicts of interest to this work.

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Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Affiliations

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources