Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection
- PMID: 32334052
- PMCID: PMC7175911
- DOI: 10.1016/j.phrs.2020.104837
Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection
Conflict of interest statement
Declaration of Competing Interest We declare no competing interests.
Comment on
-
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. Cell. 2020. PMID: 32142651 Free PMC article.
References
-
- Lucas J.M., Heinlein C., Kim T., Hernandez S.A., Malik M.S., True L.D., Morrissey C., Corey E., Montgomery B., Mostaghel E., Clegg N., Coleman I., Brown C.M., Schneider E.L., Craik C., Simon J.A., Bedalov A., Nelson P.S. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 2014;4:1310–1325. https://www.ncbi.nlm.nih.gov/pubmed/25122198/ - PMC - PubMed
-
- Böttcher E., Matrosovich T., Beyerle M., Klenk H.D., Garten W., Matrosovich M. Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. J. Virol. 2006;80:9896–9898. https://www.ncbi.nlm.nih.gov/pubmed/16973594/ - PMC - PubMed
-
- Iwata-Yoshikawa N., Okamura T., Shimizu Y., Hasegawa H., Takeda M., Nagata N. TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. J. Virol. 2019;93(6):e01815–01818. https://www.ncbi.nlm.nih.gov/pubmed/30626688/ - PMC - PubMed
-
- Hoffmann M., Kleine-Weber H., Schroeder S., Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S., Schiergens T.S., Herrler G., Wu N.H., Nitsche A., Müller M.A., Drosten C., Pöhlmann S. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020 https://www.ncbi.nlm.nih.gov/pubmed/32142651/ pii: S0092-8674(20)30229-4. - PMC - PubMed
-
- Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S. Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry. J. Virol. 2012;86:6537–6545. https://www.ncbi.nlm.nih.gov/pubmed/224962166/ - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
