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. 2020 Aug;18(9):2128-2130.e2.
doi: 10.1016/j.cgh.2020.04.040. Epub 2020 Apr 22.

ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

Furong Liu  1 , Xin Long  1 , Bixiang Zhang  1 , Wanguang Zhang  1 , Xiaoping Chen  1 , Zhanguo Zhang  2
Affiliations

ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

Furong Liu et al. Clin Gastroenterol Hepatol. 2020 Aug.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus that causes coronavirus disease 2019 (COVID-19) in human beings, has caused a serious public health issue.1 Attention to pancreatic injury is lacking, which may impact patients' prognosis. In this study, we explored the expression and distribution of angiotensin-converting enzyme 2 (ACE2), the receptor of SARS-CoV-2, in the pancreas. Combined with clinical data, we showed that pancreatic injury can occur in some COVID-19 patients.

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Figures

Figure 1
Figure 1
The expression and distribution of ACE2 in pancreas. (A) The messenger RNA level of ACE2 in multiple organs from GTEx samples. (B and D) The visualization of pancreatic cell distribution in GSE85241 and GSE84133. (C and E) The expression of ACE2 in different pancreatic cell in GSE85241 and GSE84133. ∗∗∗P < .001. UMAP, uniform manifold approximation and projection.
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