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Comment
. 2020 Jul:216:108442.
doi: 10.1016/j.clim.2020.108442. Epub 2020 Apr 23.

A strategy targeting monocyte-macrophage differentiation to avoid pulmonary complications in SARS-Cov2 infection

J Gómez-Rial  1 , F Martinón-Torres  2
Affiliations
Comment

A strategy targeting monocyte-macrophage differentiation to avoid pulmonary complications in SARS-Cov2 infection

J Gómez-Rial et al. Clin Immunol. 2020 Jul.
No abstract available

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Figures

Fig. 1
Fig. 1
Proposed strategy of IL-6 and GM-CSF blockade to avoid pulmonary complications in SARS-Cov2 infection. SARS-Cov2 replication in pulmonary tissues activates production of GM-CSF by endothelial cells and fibroblast. This produces a chemoattractant gradient that recruits peripheral blood monocytes to lungs, promoting activation and differentiation to inflammatory macrophages and production of an over-exuberant inflammatory response with increased levels of IL-6 and tissue destruction. GM-CSF: granulocyte and monocyte-colony stimulating factor; IL-6: interleukin-6.
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