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Review
. 2020 Jun:127:104372.
doi: 10.1016/j.jcv.2020.104372. Epub 2020 Apr 14.

SARS-CoV-2: Is it the newest spark in the TORCH?

Kathleen M Muldoon  1 , Karen B Fowler  2 , Megan H Pesch  3 , Mark R Schleiss  4
Affiliations
Review

SARS-CoV-2: Is it the newest spark in the TORCH?

Kathleen M Muldoon et al. J Clin Virol. 2020 Jun.

Abstract

Amid the rapidly evolving global coronavirus disease 2019 (COVID-19) pandemic that has already had profound effects on public health and medical infrastructure globally, many questions remain about its impact on child health. The unique needs of neonates and children, and their role in the spread of the virus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) should be included in preparedness and response plans. Fetuses and newborn infants may be uniquely vulnerable to the damaging consequences of congenitally- or perinatally-acquired SARS-CoV-2 infection, but data are limited about outcomes of COVID-19 disease during pregnancy. Therefore, information on illnesses associated with other highly pathogenic coronaviruses (i.e., severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome [MERS]), as well as comparisons to common congenital infections, such as cytomegalovirus (CMV), are warranted. Research regarding the potential routes of acquisition of SARS-CoV-2 infection in the prenatal and perinatal setting is of a high public health priority. Vaccines targeting women of reproductive age, and in particular pregnant patients, should be evaluated in clinical trials and should include the endpoints of neonatal infection and disease.

Keywords: COVID-19; Congenital infection; SARS-CoV-2; SARS-CoV-2 vaccines; TORCH infection.

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Conflict of interest statement

Declaration of Competing Interest None of the authors declares a competing interest.

References

    1. Cucinotta D., Vanelli M. WHO declares COVID-19 a pandemic. Acta Biomed. 2020;91(1):157–160. doi: 10.23750/abm.v91i1.9397. - DOI - PMC - PubMed
    1. https://coronavirus.jhu.edu/, Accessed 4/8/2020.
    1. Mullins E., Evans D., Viner R.M., O’Brien P., Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet. Gynecol. 2020 doi: 10.1002/uog.22014. - DOI - PubMed
    1. Karimi-Zarchi M., Neamatzadeh H., Dastgheib S.A., Abbasi H., Mirjalili S.R., Behforouz A., Ferdosian F., Bahrami R. Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: a Review. Fetal Pediatr. Pathol. 2020:1–5. doi: 10.1080/15513815.2020.1747120. - DOI - PMC - PubMed
    1. Nahmias A.J., Walls K.W., Stewart J.A. The ToRCH complex-perinatal infections associated with toxoplasmosis, rubella, cytomegalo- and herpes simplex viruses. Pediatr. Res. 1971;5:405–406.

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