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Comment
. 2020 Aug;36(8):955-957.
doi: 10.1007/s12264-020-00504-8. Epub 2020 Apr 25.

A Lower-Brainstem Structure Coordinates Acquisition of Negative Experience

Lei Li  1   2
Affiliations
Comment

A Lower-Brainstem Structure Coordinates Acquisition of Negative Experience

Lei Li. Neurosci Bull. 2020 Aug.
No abstract available

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Conflict of interest statement

The author declares no competing interest.

Figures

Fig. 1
Fig. 1
The median raphe region (MRR) is a lower-brainstem structure that coordinates the acquisition of negative experience. MRR vGluT2-neurons receive extensive inputs from negative experience-related regions and coordinate negative experience processing via three key pathways: MRR–LHb, MRR–mVTA, and MRR–MS/VDB (MRR median raphe region, vGluT2 vesicular glutamate transporter 2, LHb lateral habenula, mVTA medial ventral tegmental nucleus, MS/VDB medial septum and vertical limb of the diagonal band of Broca, PV parvalbumin, mPFC medial prefrontal cortex, PAG periaqueductal gray, ZI zona incerta, LDTg laterodorsal tegmental nucleus, LH lateral hypothalamus, LPO/VP lateral preoptic area and ventral pallidum, DR dorsal raphe, Mam mammillary complex, NI nucleus incertus).
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